Biomimetic Sensors, Catalysts, and Materials: Chemistry at the Bio/Abio Interface

仿生传感器、催化剂和材料：Bio/Abio 界面的化学

• 批准号: 2203414
• 负责人: Lauren Webb
• 金额: $ 46.42万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2203414&HistoricalAwards=false
• 关键词: Biomimetic; Sensors; Catalysts; Materials; Chemistry

With support from the Macromolecular, Supramolecular and Nanochemistry Program (MSN) in the Division of Chemistry, Professor Lauren Webb of The University of Texas at Austin is combining surface chemical synthesis and advanced chemical analytics tools to study how proteins behave in abiological contexts. Integrating biological molecules into artificial environments allows biologically relevant function to be combined with synthetic materials in order to incorporate, rather than replicate, these capabilities in an artificial context. At this so-called “bio/abio” interface, basic biological functions can be co-opted to detect analytes with exceptional sensitivity or to catalyze the synthesis of useful molecules under environmentally friendly reaction conditions. Professor Webb and her students are addressing the central challenges of preparing and characterizing these systems by combining synthetic and biological chemistry. Their discoveries could lead to new approaches for protein-based sensors, catalysts and biomaterials as they develop characterize, manipulate, and explore an entirely new generation of biologically functional materials. Professor Webb is the State Director of the Welch Summer Scholars Program (WSSP), a 39-year program that provides rising high school students in the state of Texas with an authentic, significant, and meaningful summer residential research experience in the chemical sciences. Broader Impacts activities over the next three years of this proposal will 1) develop an online summer seminar program designed for all Texas high school students and chemistry teachers; and 2) grow a WSSP alumni network for mentoring and career development of the extraordinary alumni base of this program.The long-standing, central challenge to creating biologically-inspired functional devices and materials is to integrate native biomolecular structure, dynamics, and function into an abiological environment; each “bio” and “abio” component carries its own unique set of properties that must interact in an entirely new context. Professor Webb and her students are studying the behavior of biomolecular-material interactions for each individual component to synthesize, characterize, and expand bio/abio science to sensing, catalysis, and synthesis of novel biological materials for a wide variety of potential applications. The students involved in this project will gain a wide range of experience in surface chemical synthesis and a suite of chemical analysis techniques including infrared spectroscopy, x-ray photoelectron spectroscopy (XPS), surface circular dichroism (CD) spectroscopy, neutron reflectometry (NR) and scanning probe microscopy.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系大分子，超分子和纳米化学项目（MSN）的支持下，德克萨斯大学奥斯汀分校的劳伦·韦伯教授将表面化学合成和先进的化学分析工具相结合，研究蛋白质在非生物环境中的行为。将生物分子整合到人工环境中允许将生物相关功能与合成材料相结合，以便在人工环境中整合而不是复制这些功能。在这个所谓的“生物/无机”界面上，基本的生物功能可以被增选以检测具有异常灵敏度的分析物或在环境友好的反应条件下催化有用分子的合成。韦伯教授和她的学生正在解决通过结合合成和生物化学制备和表征这些系统的核心挑战。他们的发现可能会为基于蛋白质的传感器，催化剂和生物材料带来新的方法，因为他们开发了表征，操纵和探索全新一代的生物功能材料。韦布教授是韦尔奇夏季学者计划（WSSP）的国家主任，该计划为期39年，为德克萨斯州的高中生提供了一个真实，重要和有意义的化学科学夏季住宅研究经验。更广泛的影响活动，在未来三年的这一建议将1）开发一个在线夏季研讨会计划设计的所有得克萨斯州高中学生和化学教师;和2）发展一个WSSP校友网络，为该计划的杰出校友基地提供指导和职业发展。创造生物启发的功能器件和材料的长期核心挑战是整合天然生物分子结构，每个“生物”和“非生物”成分都有自己独特的一套属性，必须在一个全新的环境中相互作用。Webb教授和她的学生正在研究每个单独组分的生物分子-材料相互作用的行为，以合成，表征和扩展生物/无机科学，以传感，催化和合成新型生物材料，用于各种潜在应用。参与该项目的学生将获得广泛的表面化学合成经验和一套化学分析技术，包括红外光谱，X射线光电子能谱（XPS），表面圆二色性（CD）光谱，中子反射计该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准。

项目成果

Acetylcholinesterase Adsorption on Modified Gold: Effect of Surface Chemistry on Enzyme Binding and Activity

• DOI: 10.1021/acs.langmuir.3c00648
• 发表时间: 2023-07-13
• 期刊: LANGMUIR
• 影响因子: 3.9
• 作者: Correira，Joshua M.;Madeksho，Diane E.;Webb，Lauren J.
• 通讯作者: Webb，Lauren J.