Targeted Infusion Project Development of a CRISPR Cas9 based gene editing technology curriculum at Tennessee State University

历史黑人学院和大学本科项目(HBCU-UP)通过有针对性的灌输项目，支持基于证据的创新模式和方法的开发、实施和研究，以改善HBCU本科学生的准备和成功，使他们可以攻读科学、技术、工程或数学(STEM)研究生课程和/或职业。该项目旨在将尖端基因编辑技术纳入田纳西州立大学(TSU)的课程，重点是基于CRISPR-Cas9(簇状规则间隔短回文重复序列)的基因组编辑，并培养精通基因编辑原理和伦理的一代学生，他们将继续成为未来的农业政策制定者、科学家和农业企业管理人员，以符合国家科学基金会促进科学进步的使命。CRISPR-Cas9课程将(1)提供一门专门的课程，培训本科生学习这一尖端技术，(2)增加学生进入农业和生物科学研究生课程的预科，以及(3)为其他历史上的黑人学院或大学的教师提供为期两天的研讨会，让他们在TSU接受现场培训，以便他们可以根据自己提供的学位来调整材料。此外，活动结果将通过出版物、会议报告、以及通过台州大学农学院社交媒体渠道和参与活动的私人投资者和高级人员的个人社交媒体账户向更广泛的社区传播。该项目将对农业和生物科学系的教育和研究产生重大影响，并极大地提高学生在新兴技术方面的知识，为他们的研究生学习和STEM工作做好更好的准备。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The Historically Black Colleges and Universities Undergraduate Program (HBCU-UP) through Targeted Infusion Projects supports the development, implementation, and study of evidence-based, innovative models and approaches for improving the preparation and success of HBCU undergraduate students so that they may pursue science, technology, engineering, or mathematics (STEM) graduate programs and/or careers. This project seeks to incorporate cutting-edge gene editing technologies with a focus on CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats)-based genome editing into the curriculum at Tennessee State University (TSU) and train a generation of students well-versed in the principles and ethics of gene editing, who go on to become future agricultural policy makers, scientists, and agribusiness managers in keeping with the National Science Foundation’s mission to promote the progress of science.The CRISPR-Cas9 course will (1) offer a dedicated course to train undergraduates in this cutting-edge technology, (2) increase the matriculation of students into agricultural and biological sciences graduate programs, and (3) provide a two-day workshop for faculty from other Historically Black Colleges or Universities to be trained on-site at TSU so that they can adapt the material to their own degree offerings. In addition, the results of the activities will be disseminated to the broader communities through publications, conference presentations, and via the TSU College of Agriculture social media channels and personal social media accounts of participating PIs and senior personnel. This project will have significant impact on the education and research in the agricultural and biological science departments, and greatly improve students’ knowledge in emerging technologies, better preparing them for graduate study and the STEM workforce.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.