Epidemiological risk factors of the bladder exstrophy-epispadias complex

膀胱外翻-尿道上裂综合征的流行病学危险因素

• 批准号: 251782188
• 负责人: Professorin Dr. Anne-Karoline Ebert
• 金额: --
• 依托单位: Klinik und Poliklinik für Kinder- und Jugendpsychiatrie und -psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/251782188?language=en
• 关键词: Epidemiological; risk; factors; bladder; exstrophy

The bladder exstrophy-epispadias complex (BEEC) is a major birth defect, nowadays understood as a spectrum from mild glandular epispadias to the multisystem defect of the cloacal exstrophy. Involving various organ systems at different levels the underlying course is assumed to be multifactorial with interplay of genetic and environmental factors. The BEEC prevalence varies according to the severity of the anomaly. However, the prevalence in Germany is unclear due to a lack of centralised data acquisition. Despite intense and dedicated clinical and experimental research during the last years clinical related outcome issues are unsolved. Patients suffer from lifelong physical and psychosocial problems due to genital or continence outcome. Current knowledge on the underlying causes and epidemiologic risk factors is still sparse. It is common knowledge that urogenital malformation might be caused by environmental factors, medication or noxes, paternal factors, morbidity and subfertility, as well as child related parameter like birth plurality. Aim of the present multicenter case-control study is to estimate the significance of potential empirically derived prenatal risk factors quantitatively with minimal selection bias. For patient recruitment, a well-arranged German-wide network is available. Using a standardized methodology including standardised questionnaires and medical documents, possible risk factors and confounders will be collected. The influence of potential risk factors, which is independent of confounders, is estimated using multivariable logistic regression. In addition to already analysed 40 newborns with BEEC, 60 newborns will be recruited as part of a nationwide register, established by the applicant. Terminations following pregnancy diagnosis of BEEC and still births of affected children will be recruited by birth clinics, if necessary by pathologies throughout Germany.

膀胱外翻-外翻复合体(BEEC)是一种主要的出生缺陷，目前被理解为从轻度的腺外翻到泄殖腔外翻的多系统缺陷。涉及不同级别的不同器官系统，其基本过程被认为是遗传和环境因素相互作用的多因素。BEEC的患病率根据异常的严重程度而不同。然而，由于缺乏集中的数据采集，这种情况在德国的流行程度尚不清楚。尽管在过去几年中进行了密集和专注的临床和实验研究，但与临床相关的结果问题仍未得到解决。由于生殖器或大小便失禁的结果，患者遭受终生的身体和心理社会问题。目前对根本原因和流行病学风险因素的了解仍然很少。众所周知，泌尿生殖系统畸形可能是由环境因素、药物或毒素、父亲因素、发病率和不孕不育以及与儿童有关的参数(如生育次数)引起的。这项多中心病例对照研究的目的是以最小的选择偏差来定量评估潜在的经验性产前危险因素的重要性。对于患者招募，我们提供了一个安排良好的德国范围的网络。使用包括标准化问卷和医疗文件在内的标准化方法，收集可能的风险因素和混杂因素。用多变量Logistic回归估计与混杂因素无关的潜在危险因素的影响。除了已经分析的40名患有BEEC的新生儿外，还有60名新生儿将被招募，作为申请者建立的全国登记的一部分。在被诊断为BEEC和受影响儿童的死产后，如果有必要，德国各地的病理机构将招募分娩诊所进行终止妊娠。

项目成果

Morphological and Functional Hip Long-Term Results after Exstrophy Repair.

髋关节外翻修复后的形态和功能长期结果

• DOI: 10.1055/s-0035-1564711
• 发表时间: 2016
• 期刊: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
• 作者: Kertai MA;Rösch WH;Brandl R;Hirschfelder H;Zwink N;Ebert AK
• 通讯作者: Ebert AK

Sexual Function and Quality of Life in Adult Male Individuals with Exstrophy-Epispadias Complex-a Survey of the German CURE-Network.

患有尿道外翻综合症的成年男性的性功能和生活质量——德国 CURE 网络的调查

• DOI: 10.1016/j.urology.2017.08.063
• 发表时间: 2018
• 期刊: Urology
• 影响因子: 2.1
• 作者: Traceviciute J;Zwink N;Jenetzky E;Reutter H;Hirsch K;Stein R;Rösch WH;Ebert AK
• 通讯作者: Ebert AK

Sexual function in adult patients with classic bladder exstrophy: A multicenter study.

典型膀胱外翻成年患者的性功能：一项多中心研究

• DOI: 10.1016/j.jpurol.2015.02.001
• 发表时间: 2015
• 期刊: Journal of pediatric urology
• 影响因子: 2
• 作者: Park W;Zwink N;Ebert A-K;Rösch W-H;Schmiedeke E;Stein R;Schmidt D;Noeker M;Jenetzky E;Reutter H
• 通讯作者: Reutter H

Evaluation of sexual function in females with exstrophy-epispadias-complex: A survey of the multicenter German CURE-Net.

尿道外翻综合症女性性功能的评估：德国多中心 CURE-Net 的调查

• DOI: 10.1016/j.jpurol.2016.04.052
• 发表时间: 2017
• 期刊: Journal of pediatric urology
• 影响因子: 2
• 作者: Ebert AK;Lange T;Reutter H;Jenetzky E;Stein R;Boemers TM;Hirsch K;Rösch WH;Zwink N
• 通讯作者: Zwink N

Needs Assessment in Care of Adults With Anorectal Malformations and Exstrophy-Epispadias Complex in Germany

德国成人肛门直肠畸形和尿道外翻综合症的护理需求评估

• DOI: 10.3389/fped.2018.00392
• 发表时间: 2018
• 期刊: Frontiers in Pediatrics
• 影响因子: 2.6
• 作者: Ebert AK;Zwink N;Schwarzer N;Brunner L;Reutter H;Jenetzky E;Huber J;Ludwikowski B
• 通讯作者: Ludwikowski B