MPS-Ascend: Development of a Dual Catalytic Fragment Insertion Reaction

MPS-Ascend：双催化片段插入反应的开发

• 批准号: 2213302
• 负责人: Skyler Mendoza
• 金额: $ 30万
• 依托单位: Mendoza, Skyler Dakota
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2213302&HistoricalAwards=false
• 关键词: MPS; Ascend; Development; Dual; Catalytic

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). Skyler Mendoza is awarded a NSF Mathematical and Physical Sciences Ascending Postdoctoral Research Fellowship (NSF MPS-Ascend) to conduct a program of research and activities related to broaden participation by groups underrepresented in STEM. This fellowship to Dr. Mendoza supports the research project entitled " MPS-Ascend: Development of a Dual Catalytic Fragment Insertion Reaction", under the mentorship of a sponsoring scientist. The host institution for the fellowship is the Scripps Research Institute, and the sponsoring scientist is Dr. Keary Engle. The proposed work intends to explore the concept of fragment insertion/deletion, also referred to as “molecular editing”. This reaction would take simple, easy-to-access 1,3-dienes and convert them into otherwise difficult to access value-added 1,4-diene products. Successful implementation of the work will result in the establishment of a conceptually distinct method for accessing skipped diene products. The PI will prioritize community outreach for young scientists historically excluded from the field of organic chemistry through a collaboration with the Society of Hispanic Professional Engineers (SHPE) at the University of California San Diego. Successful implementation of this collaboration will result in the creation of a “MentorSHPE” program at the Scripps Research Institute.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项的全部或部分资金来自《2021年美国救援计划法案》(公法117-2)。斯凯勒·门多萨被授予NSF数学和物理科学提升博士后研究奖学金(NSF MPS-Ascend)，以开展一项与扩大STEM中代表性不足群体的参与相关的研究和活动。门多萨博士的这笔奖学金支持在一位赞助科学家的指导下进行的题为“MPS-Ascend：双催化片段插入反应的发展”的研究项目。该奖学金的主办机构是斯克里普斯研究所，发起科学家是基里·恩格尔博士。这项拟议的工作意在探索片段插入/删除的概念，也称为“分子编辑”。该反应将以简单、容易获得的1，3-二烯为原料，并将它们转化为原本难以获得附加值的1，4-二烯产品。这项工作的成功实施将导致建立一种概念上截然不同的方法来获取跳过的二烯产品。PI将通过与加州大学圣地亚哥分校西班牙裔专业工程师协会(SHPE)的合作，优先向历史上被排除在有机化学领域之外的年轻科学家提供社区宣传。这一合作的成功实施将导致在斯克里普斯研究所创建一个“MentorSHPE”计划。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。