MRI: Acquisition of a Trapped Ion Mobility Spectrometer Quadrupole Time-of-Flight (TIMS-QTOF) with MALDI for Multidisciplinary Research and Education
MRI:使用 MALDI 获取捕获离子淌度光谱仪四极杆飞行时间 (TIMS-QTOF),用于多学科研究和教育
基本信息
- 批准号:2216089
- 负责人:
- 金额:$ 109.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-10-01 至 2025-09-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
This proposal seeks to acquire a state-of-the-art Trapped Ion Mobility Spectrometry (TIMS) Time of Flight (TOF) fleX with Matrix Assisted Laser Desorption/Ionization (MALDI). This instrument offers several unique capabilities: 1) TIM separation allows separating isomeric compounds. These compounds have the same molecular formula, but different chemical properties; 2) TOF enables full mass-spectrum analysis and is able to separate species that differ in mass by as little as 0.001 atomic mass unit; and 3) Mass Spectrometry Imaging is label free, provides untargeted analysis of thousands of molecular species simultaneously, offers extremely low limits of detection, and provides spatial mapping. The capability of this instrument will allow the project team to fill knowledge gaps and tackle pressing challenges in a wide range of scientific fields: environmental monitoring and remediation, biological, chemical, biochemical, and biomedical sciences. Access to this instrument will strengthen research at three Institutions and the Wadsworth Center at the Capital Region of New York and beyond. Besides benefiting the society through new discoveries and deep scientific endeavors, this instrument will be used for educating and training undergraduate and graduate students and outreach to the general public, and K-12 educators and students. The proposed instrument will address critical challenges faced by at least ten researchers in multiple fields of research. This is enabled by the instrument’s revolutionary capabilities in visualizing molecules in chemically complex microenvironments and providing quantitative compositional and structural analyses. These capabilities will bring game-changing discoveries in research related to oral microbial community, dental biofilm, fungal metabolome and proteome, RNA modifications, and epitranscriptome. In environmental impact analysis and remediation, this instrument will be used to detect and quantify isomers of per- and polyfluorinated substances (PFAS) and perform targeted screening and non-target analysis of these compounds in different environmental matrices. In the field of glycomics, the full structural characterization of carbohydrates is a standing analytical need in the characterization of structure-function relationships as well as biomedical applications. The proposed equipment permits confident isomer differentiation and structure elucidation and provides a sensitive and rapid overview of glycan profiles for complex glycoprotein mixtures. With respect to the Drosophila -parasitoid wasp interaction, the immune response of the host fly to another insect, the infecting wasp is largely unknown. The acquired instrument would enable deep understanding of changes at protein levels and localizing the cellular immune response through MALDI imaging.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该提案旨在获得最先进的捕获离子迁移谱(TIMS)飞行时间(TOF)flexX与基质辅助激光解吸/电离(MALDI)。该仪器提供了几个独特的功能:1)TIM分离允许分离异构体化合物。这些化合物具有相同的分子式,但不同的化学性质; 2)TOF能够进行全质谱分析,并能够分离质量相差仅0.001原子质量单位的物质; 3)质谱成像是无标记的,同时提供数千种分子物质的非靶向分析,提供极低的检测限,并提供空间映射。这一工具的能力将使项目小组能够填补知识空白,并应对广泛科学领域的紧迫挑战:环境监测和补救,生物,化学,生物化学和生物医学科学。利用这一工具将加强三个机构和纽约首都地区的沃兹沃斯中心及其他地方的研究。除了通过新发现和深入的科学努力造福社会外,该仪器还将用于教育和培训本科生和研究生,并推广到公众,以及K-12教育工作者和学生。拟议的工具将解决多个研究领域至少10名研究人员面临的关键挑战。这得益于该仪器在化学复杂微环境中可视化分子并提供定量成分和结构分析的革命性能力。这些能力将为口腔微生物群落、牙齿生物膜、真菌代谢组和蛋白质组、RNA修饰和表观转录组相关的研究带来改变游戏规则的发现。在环境影响分析和补救方面,该仪器将用于检测和量化全氟和多氟物质的异构体,并对不同环境基质中的这些化合物进行有针对性的筛选和非目标分析。在糖组学领域,碳水化合物的完整结构表征是结构-功能关系表征以及生物医学应用的长期分析需求。拟议的设备允许有信心的异构体的分化和结构的阐明,并提供了一个敏感和快速的概述复杂的糖蛋白混合物的聚糖概况。关于果蝇-寄生蜂的相互作用,宿主苍蝇对另一种昆虫的免疫反应,感染黄蜂在很大程度上是未知的。获得的仪器将能够深入了解蛋白质水平的变化,并通过MALDI成像定位细胞免疫反应。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Yanna Liang其他文献
Biodegradation of Pyrene in Soil Microcosms: Identification of a Toxic Intermediate
土壤微观世界中芘的生物降解:有毒中间体的鉴定
- DOI:
10.1061/40792(173)4 - 发表时间:
2005 - 期刊:
- 影响因子:2.7
- 作者:
Yanna Liang - 通讯作者:
Yanna Liang
Optimization of sugar release from sweet sorghum bagasse following solvation of cellulose and enzymatic hydrolysis using response surface methodology
使用响应面法优化纤维素溶剂化和酶水解后甜高粱甘蔗渣的糖释放
- DOI:
10.1002/btpr.1851 - 发表时间:
2014 - 期刊:
- 影响因子:2.9
- 作者:
J. Yesuf;Yanna Liang - 通讯作者:
Yanna Liang
Environmental and health impacts of PFAS: Sources, distribution and sustainable management in North Carolina (USA)
全氟烷基物质对环境和健康的影响:美国北卡罗来纳州的来源、分布和可持续管理
- DOI:
10.1016/j.scitotenv.2023.163123 - 发表时间:
2023-06-20 - 期刊:
- 影响因子:8.000
- 作者:
Mohammad Nazmul Ehsan;Mumtahina Riza;Md. Nahid Pervez;Mirza Mohammad Omar Khyum;Yanna Liang;Vincenzo Naddeo - 通讯作者:
Vincenzo Naddeo
A Critical Review of Challenges Faced by Converting Food Waste to Bioenergy Through Anaerobic Digestion and Hydrothermal Liquefaction
- DOI:
10.1007/s12649-021-01540-9 - 发表时间:
2021-08 - 期刊:
- 影响因子:3.2
- 作者:
Yanna Liang - 通讯作者:
Yanna Liang
Sweet sorghum bagasse and corn stover serving as substrates for producing sophorolipids
甜高粱渣和玉米秸秆作为槐糖脂生产基质
- DOI:
10.1007/s10295-016-1891-y - 发表时间:
2017 - 期刊:
- 影响因子:3.4
- 作者:
A. Samad;J. Zhang;Da Chen;Xiaowen Chen;M. Tucker;Yanna Liang - 通讯作者:
Yanna Liang
Yanna Liang的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Yanna Liang', 18)}}的其他基金
Collaborative Research: ERASE-PFAS: Stabilization of Per- and Polyfluorinated Substances in Sewage Sludge Intended for Land-application
合作研究:ERASE-PFAS:用于土地应用的污水污泥中全氟和多氟物质的稳定化
- 批准号:
2225596 - 财政年份:2022
- 资助金额:
$ 109.9万 - 项目类别:
Standard Grant
相似海外基金
Doctoral Dissertation Research: Aspect and Event Cognition in the Acquisition and Processing of a Second Language
博士论文研究:第二语言习得和处理中的方面和事件认知
- 批准号:
2337763 - 财政年份:2024
- 资助金额:
$ 109.9万 - 项目类别:
Standard Grant
Collaborative Research: LTREB: The importance of resource availability, acquisition, and mobilization to the evolution of life history trade-offs in a variable environment.
合作研究:LTREB:资源可用性、获取和动员对于可变环境中生命史权衡演变的重要性。
- 批准号:
2338394 - 财政年份:2024
- 资助金额:
$ 109.9万 - 项目类别:
Continuing Grant
EA: Acquisition of analytical equipment for environmental biogeochemistry and mineralogy
EA:购置环境生物地球化学和矿物学分析设备
- 批准号:
2323242 - 财政年份:2024
- 资助金额:
$ 109.9万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 109.9万 - 项目类别:
Standard Grant
EA/Ed: Acquisition of a carbon dioxide and methane Cavity Ringdown Spectrometer for education and research
EA/Ed:购买二氧化碳和甲烷腔衰荡光谱仪用于教育和研究
- 批准号:
2329285 - 财政年份:2024
- 资助金额:
$ 109.9万 - 项目类别:
Standard Grant
The effect of AI-assisted summary writing on second language acquisition
人工智能辅助摘要写作对第二语言习得的影响
- 批准号:
24K04154 - 财政年份:2024
- 资助金额:
$ 109.9万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Conference: Child Language Acquisition Symposium for Indigenous Communities
会议:土著社区儿童语言习得研讨会
- 批准号:
2410232 - 财政年份:2024
- 资助金额:
$ 109.9万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Effects of non-verbal working memory and spoken first language proficiency on sign language acquisition by deaf second language learners
博士论文研究:非语言工作记忆和第一语言口语能力对聋哑第二语言学习者手语习得的影响
- 批准号:
2336589 - 财政年份:2024
- 资助金额:
$ 109.9万 - 项目类别:
Standard Grant
Collaborative Research: LTREB: The importance of resource availability, acquisition, and mobilization to the evolution of life history trade-offs in a variable environment.
合作研究:LTREB:资源可用性、获取和动员对于可变环境中生命史权衡演变的重要性。
- 批准号:
2338395 - 财政年份:2024
- 资助金额:
$ 109.9万 - 项目类别:
Continuing Grant
EA: Acquisition of an X-ray Fluorescence Spectrometer for Research, Undergraduate Education, and STEM Outreach
EA:购买 X 射线荧光光谱仪用于研究、本科教育和 STEM 推广
- 批准号:
2327202 - 财政年份:2024
- 资助金额:
$ 109.9万 - 项目类别:
Standard Grant