Models for the spermatogonial stem cell niche and its regulation

这一国际项目旨在研究与男性生育力和精原干细胞生态位有关的两个新方面。(1)我们想要探索季节性繁殖者金黄地鼠的睾丸细胞培养是否可以为研究精原干细胞生态位的调节和机制开发新的细胞模型。在这个物种中，睾丸功能和生育能力的光周期调节也涉及前列腺素。(2)由于金黄地鼠和不育男性中的前列腺素作为睾丸因子进化，我们想要从细胞的角度探索精原干细胞的生态位是否会受到前列腺素的影响。通过结合我们的专业知识，这是可能的：阿根廷实验室在金黄仓鼠及其睾丸细胞和功能以及睾丸前列腺素领域拥有经验。德国的实验室在睾丸免疫细胞、小管周围细胞以及最近的SSC利基领域拥有额外的专业知识。为了检验这两点，有必要对伙伴实验室进行访问，并为用品提供资金，这可能会导致未来有一个共同的、重点突出的项目。

This international project aims to study two novel aspects related to male (in)fertility and the spermatogonial stem cell niche. (1) We want to explore whether cell cultures of testicular cells from a seasonal breeder, the golden hamster, may allow to develop new cellular models for the study of the regulation and the mechanism of the spermatogonial stem cell niche. In this species photoperiodic regulation of testicular function and fertility occurs, which also involves prostaglandins.(2) Because prostaglandins in the golden hamster and in infertile men evolve as testicular factors, we want to explore, in cellular approaches, whether the spermatogonial stem cell niche may be influenced by prostaglandins. This is possible by combining our expertise: The Argentinean lab has experience in the area of the golden hamster and its testicular cells and functions, as well as testicular prostaglandins. The lab in Germany has additional expertise in the area of testicular immune cells, peritubular cells and recently also the SSC niche. Visits in the partner laboratories and funds for supplies are necessary to test the two points, which may lead to a common, focused project in the future.