IntBIO COLLABORATIVE RESEARCH: Integrating fossils, genomics, and machine learning to reveal drivers of Cretaceous innovations in flowering plants
IntBIO 协作研究:整合化石、基因组学和机器学习,揭示白垩纪开花植物创新的驱动因素
基本信息
- 批准号:2217116
- 负责人:
- 金额:$ 103.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The Tree of Life is marked by short periods of rapid innovation where groups emerge with dramatically altered forms and diversify quickly. This has happened multiple times throughout geologic history including with the rise of birds, mammals, the transition of plants from water to land, and the origination of flowering plants. The rapid emergence and diversification of flowering plants in particular represents one of the most remarkable episodes in the history of life on earth. However, while fundamental to understanding the ecology and evolution of modern ecosystems, this episode remains unexplained and leads to one of the grand challenges in the biological sciences – determining what processes may be responsible for such rapid changes in form and function across the Tree of Life. A major impediment to addressing this question is the availability of data and methods for analyzing those data. The goal of this study is to use and develop new machine learning approaches to gathering data for both fossil and living plant species and to use these data to help develop new techniques. These techniques will help identify what contributed to the rapid change in plants that resulted in their dominance in the environment today. This project will train undergraduates, graduate students, and postdoctoral fellows in machine learning methods, evolutionary biology, and techniques for working with both fossil and living specimens. The project will also include resource development and training for middle schoolers, high schoolers, undergraduates, and the broader research community.This project aims to evaluate the evolutionary processes underlying the emergence of innovation, using flowering plants as a case study. Specifically, the project will examine Cretaceous radiations of flowering plants characterized by rapid evolution, a rich fossil record, and the origin of innovations and lineages of great ecological significance. The central goals of the proposed research are to (a) generate a large morphological dataset for flowering plants using novel machine learning methods, (b) develop new statistical methods for modeling evolution, and (c) use these advances in data collection and methods to identify the processes that led to the episodic and rapid emergence of novelty across the Tree of Life. Collectively, these new developments in machine learning techniques, morphological data collection, and analytical techniques for addressing evolutionary processes will be potentially transformative to several fields including the biological sciences, computational biology, and machine learning. The large scope and scale of this project, together with its highly integrative nature, creates the potential to address one of the most important standing questions in evolutionary biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
生命之树的特点是短期的快速创新,其中群体出现了戏剧性的变化形式和迅速多样化。这种情况在整个地质历史中发生过多次,包括鸟类,哺乳动物的兴起,植物从水到陆地的过渡,以及开花植物的起源。显花植物的迅速出现和多样化尤其代表了地球生命史上最引人注目的事件之一。然而,尽管这一事件对于理解现代生态系统的生态学和进化至关重要,但它仍然无法解释,并导致了生物科学的重大挑战之一-确定什么过程可能导致生命之树的形式和功能发生如此迅速的变化。解决这一问题的一个主要障碍是数据和分析这些数据的方法的可用性。这项研究的目标是使用和开发新的机器学习方法来收集化石和活植物物种的数据,并使用这些数据来帮助开发新技术。 这些技术将有助于确定是什么促成了植物的快速变化,导致它们在今天的环境中占据主导地位。该项目将培训本科生,研究生和博士后研究员机器学习方法,进化生物学,以及与化石和活标本一起工作的技术。该项目还将包括为初中生、高中生、大学生和更广泛的研究社区提供资源开发和培训。该项目旨在以开花植物为案例研究,评估创新出现的进化过程。具体而言,该项目将研究白垩纪开花植物的辐射,其特点是快速进化,丰富的化石记录,以及具有重要生态意义的创新和谱系的起源。拟议研究的中心目标是(a)使用新的机器学习方法为开花植物生成一个大型形态数据集,(B)开发新的统计方法来建模进化,以及(c)使用数据收集和方法中的这些进步来识别导致生命之树中新奇事物的偶发和快速出现的过程。总的来说,机器学习技术、形态学数据收集和用于解决进化过程的分析技术的这些新发展将对包括生物科学、计算生物学和机器学习在内的多个领域产生潜在的变革性影响。该项目的大范围和规模,以及它的高度综合性,创造了解决进化生物学中最重要的常设问题之一的潜力。该奖项反映了NSF的法定使命,并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。
项目成果
期刊论文数量(0)
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专利数量(0)
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Stephen Smith其他文献
Highway Corridor Transformation Research Study - Proof of Concept
公路走廊改造研究 - 概念验证
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Donald Carter;Stephen Quick;Stephen Smith;C. Mondor;P. Folan - 通讯作者:
P. Folan
‘A lot more to learn than where babies come from’: controversy, language and agenda setting in the framing of school-based sexuality education curricula in Australia
“需要学习的东西比婴儿从哪里来的多得多”:澳大利亚学校性教育课程框架中的争议、语言和议程设置
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Barrie Shannon;Stephen Smith - 通讯作者:
Stephen Smith
Outcomes of faecal occult blood tests requested outside the UK National Bowel Cancer Screening Programme
英国国家肠癌筛查计划之外要求的粪便潜血检测结果
- DOI:
10.1136/jclinpath-2011-200406 - 发表时间:
2013 - 期刊:
- 影响因子:3.4
- 作者:
Rosie Mcdonald;A. Tomlins;Stephen Smith;C. Harmston - 通讯作者:
C. Harmston
COMMISSIONING AND PERFORMANCE OF LCLS CAVITY BPMS
LCLS 腔 BPMS 的调试和性能
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
Stephen Smith;S. Hoobler;Ronald G. Johnson;T. Straumann;A. Young;A. U.S;R. Lill;L. Morrison;E. Norum;N. Sereno;G. Waldschmidt;Dean;Walters - 通讯作者:
Walters
Online Video Teletherapy Treatment of Obsessive-Compulsive Disorder Using Exposure and Response Prevention: Clinical Outcomes From a Retrospective Longitudinal Observational Study
使用暴露和反应预防的在线视频远程治疗治疗强迫症:回顾性纵向观察研究的临床结果
- DOI:
10.2196/preprints.36431 - 发表时间:
2022 - 期刊:
- 影响因子:7.4
- 作者:
Jamie D. Feusner;Nicholas R. Farrell;Jeremy Kreyling;P. McGrath;A. Rhode;T. Faneuff;S. Lonsway;R. Mohideen;J. Jurich;L. Trusky;Stephen Smith - 通讯作者:
Stephen Smith
Stephen Smith的其他文献
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{{ truncateString('Stephen Smith', 18)}}的其他基金
Collaborative Research: BoCP-Implementation: Integrating Traits, Phylogenies and Distributional Data to Forecast Risks and Resilience of North American Plants
合作研究:BoCP-实施:整合性状、系统发育和分布数据来预测北美植物的风险和恢复力
- 批准号:
2325835 - 财政年份:2024
- 资助金额:
$ 103.11万 - 项目类别:
Standard Grant
Collaborative Research: BEE: Bridging the ecology and evolution of East African Acacias across time and space: genomics, ecosystem, and diversification
合作研究:BEE:跨越时间和空间连接东非金合欢的生态和进化:基因组学、生态系统和多样化
- 批准号:
2106070 - 财政年份:2021
- 资助金额:
$ 103.11万 - 项目类别:
Standard Grant
NSFDEB-NERC: Collaborative research: Plant chemistry and its impact on diversification and habitat of plants adapted to extreme environments
NSFDEB-NERC:合作研究:植物化学及其对适应极端环境的植物多样化和栖息地的影响
- 批准号:
1938969 - 财政年份:2020
- 资助金额:
$ 103.11万 - 项目类别:
Standard Grant
RAPID: Algorithms and Heuristics for Remote Food Delivery under Social Distancing Constraints
RAPID:社交距离约束下远程食品配送的算法和启发式
- 批准号:
2032262 - 财政年份:2020
- 资助金额:
$ 103.11万 - 项目类别:
Standard Grant
CIBR: Collaborative Research: Integrating data communities with BiotaPhy: a computational platform for data-intensive biodiversity research and training
CIBR:协作研究:将数据社区与 BiotaPhy 相集成:用于数据密集型生物多样性研究和培训的计算平台
- 批准号:
1930030 - 财政年份:2019
- 资助金额:
$ 103.11万 - 项目类别:
Standard Grant
Collaborative Research: Temperate radiations and tropical dominance: the diversification and evolution of the plant clade Ericales
合作研究:温带辐射和热带优势:植物分支杜鹃花目的多样化和进化
- 批准号:
1917146 - 财政年份:2019
- 资助金额:
$ 103.11万 - 项目类别:
Standard Grant
Computational Analysis of Transcription and Alternative Splicing Events in Squamous Cell Cancer.
鳞状细胞癌转录和选择性剪接事件的计算分析。
- 批准号:
MR/R001146/1 - 财政年份:2018
- 资助金额:
$ 103.11万 - 项目类别:
Fellowship
IIS-RI: ICAPS 2016 Doctoral Consortium Travel Awards
IIS-RI:ICAPS 2016 博士联盟旅行奖
- 批准号:
1630144 - 财政年份:2016
- 资助金额:
$ 103.11万 - 项目类别:
Standard Grant
Collaborative Research: School Segregation and Resegregation: Using Case Studies and Public Polls to Understand Citizen Attitudes
合作研究:学校隔离和重新隔离:利用案例研究和公众民意调查来了解公民的态度
- 批准号:
1527762 - 财政年份:2015
- 资助金额:
$ 103.11万 - 项目类别:
Standard Grant
Collaborative Research: ABI Innovation: Connecting resources to enable large-scale biodiversity analyses.
合作研究:ABI 创新:连接资源以实现大规模生物多样性分析。
- 批准号:
1458466 - 财政年份:2015
- 资助金额:
$ 103.11万 - 项目类别:
Standard Grant
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