IntBIO: Collaborative Research: Silk Protein Innovation and Novelty (SPIN) : integrating across disciplines to decipher silk fiber evolution

IntBIO:合作研究:丝蛋白创新与新颖(SPIN):跨学科整合,破译丝纤维的进化

基本信息

  • 批准号:
    2217159
  • 负责人:
  • 金额:
    $ 138.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-01 至 2027-07-31
  • 项目状态:
    未结题

项目摘要

Silk is one of nature’s strongest and lightest biomaterials. It is used by hundreds of thousands of species for an array of applications. Yet, outside of a few species, little is known about the genomic basis and material properties of natural silks. This project takes an integrative approach to examine the molecular, developmental, and functional basis of silk across a diversity of uses. An integrative team of natural historians, molecular biologists, developmental biologists, and bioengineers are combining their expertise to gain insight into how nature shapes silk fiber function. This research is foundational to engineering new materials that can applied to many products, from surgical adhesives to sustainable clothing. As part of this project, multiple postdoctoral researchers and graduate students gain interdisciplinary training in genomics, gene editing, and engineering. Furthermore, this project creates a traveling museum exhibit to educate the public about the natural properties of silk.Silk has been shaped and re-adapted for an extraordinary diversity of uses across multiple distantly related arthropod groups and hundreds of millions of years of evolution. To date, silk research in insects has focused largely on fibers from the domesticated silkworm moth, Bombyx mori. This project uses a comparative, multi-tiered approach to study silks of the most dominant clade of silk-producing insects, the caddisflies and moths. The combination of genomics, proteomics, functional genetics, and biophysical measurements will illuminate how silks adhere to underwater substrates, how they consolidate into an insoluble fiber, and help understand the molecular basis of their mechanical properties. Evolutionary correlations are woven between genotypes and phenotypes and direct tests of causality are conducted in strategically chosen focal species that are amenable to genetic modification. Overall, this project addresses the overarching question, “How does nature shape silk fiber function?” with a new framework for a fundamental biological superstructure that has untapped potential for the production of new polymer-based biomaterials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
丝绸是自然界最坚固、最轻的生物材料之一。它被成千上万的物种用于一系列的应用。然而,除了少数物种外,人们对天然丝绸的基因组基础和材料特性知之甚少。这个项目采取综合的方法来研究不同用途的丝绸的分子、发育和功能基础。一个由自然历史学家、分子生物学家、发育生物学家和生物工程师组成的综合团队正在结合他们的专业知识,深入了解自然如何塑造丝绸纤维的功能。这项研究为设计可应用于从外科粘合剂到可持续服装的许多产品的新材料奠定了基础。作为该项目的一部分,多名博士后研究人员和研究生获得了基因组学、基因编辑和工程学方面的跨学科培训。此外,该项目还创建了一个巡回博物馆展览,教育公众关于丝绸的自然属性。丝绸经过塑造和重新调整,以适应多个遥远的节肢动物群体和数亿年的进化过程中非凡的多样化用途。迄今为止,昆虫的蚕丝研究主要集中在家蚕蛾的纤维上。这个项目使用了一种比较的、多层次的方法来研究最主要的产丝昆虫分支--瓢虫和飞蛾的丝质。基因组学、蛋白质组学、功能遗传学和生物物理测量的结合将阐明丝绸如何附着在水下基质上,它们如何凝结成不溶性纤维,并有助于了解其机械性能的分子基础。在基因类型和表型之间编织着进化的相关性,并在经过战略选择的、可接受基因修改的重点物种中进行直接因果关系测试。总体而言,这个项目解决了一个最重要的问题,“大自然如何塑造丝绸纤维的功能?”这一奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Larval and Pupal Silk Variation in the Indian Meal Moth (Plodia interpunctella): the Impact of Overcrowding and Temperature
  • DOI:
    10.18473/lepi.77i2.a5
  • 发表时间:
    2023-05
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Toshita V. Barve;R. Godfrey;Caroline G. Storer;A. Kawahara
  • 通讯作者:
    Toshita V. Barve;R. Godfrey;Caroline G. Storer;A. Kawahara
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Akito Kawahara其他文献

Akito Kawahara的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Akito Kawahara', 18)}}的其他基金

Collaborative Research: Acoustic Deflection in Bat-Moth Interactions: Revealing the Mechanism and Evolution of a Sensory Illusion
合作研究:蝙蝠与飞蛾相互作用中的声学偏转:揭示感官错觉的机制和演变
  • 批准号:
    1920895
  • 财政年份:
    2019
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
DISSERTATION RESEARCH: Characterization of vertebrate host communities through mosquito blood meal-derived DNA for biodiversity conservation and epidemiological applications
论文研究:通过蚊血粉衍生的 DNA 表征脊椎动物宿主群落,用于生物多样性保护和流行病学应用
  • 批准号:
    1701975
  • 财政年份:
    2017
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
Digitization TCN: Collaborative Research: Lepidoptera of North America Network: Documenting Diversity in the Largest Clade of Herbivores
数字化 TCN:合作研究:北美鳞翅目网络:记录最大食草动物分支的多样性
  • 批准号:
    1601369
  • 财政年份:
    2016
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Continuing Grant
Collaborative Research: ButterflyNet--an integrative framework for comparative biology
合作研究:ButterflyNet——比较生物学的综合框架
  • 批准号:
    1541500
  • 财政年份:
    2016
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Continuing Grant
NSF DEB-NERC: Phylogenomics and Sensory Systems Evolution in Silkmoths and Relatives
NSF DEB-NERC:蚕蛾及其近缘种的系统基因组学和感觉系统进化
  • 批准号:
    1557007
  • 财政年份:
    2016
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Continuing Grant
CSBR: Natural History Collections: Building a central database and curation improvements for The McGuire Center for Lepidoptera at the Florida Museum of Natural History
CSBR:自然历史收藏:为佛罗里达自然历史博物馆的麦奎尔鳞翅目中心建立中央数据库和管理改进
  • 批准号:
    1349345
  • 财政年份:
    2014
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Continuing Grant
SG: ARTS: Hawaiian Philodoria green-island leaf mining moths: Revisionary systematics, phylogenetics and biogeography of a threatened fauna
SG:艺术:夏威夷绿岛采叶蛾:受威胁动物区系的修订系统学、系统发育学和生物地理学
  • 批准号:
    1354585
  • 财政年份:
    2014
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
Collaborative Research: Alternative strategies and evolutionary routes in the escalation of the bat-moth arms race: Ultrasonic stridulation in hawkmoths
合作研究:蝙蝠蛾军备竞赛升级的替代策略和进化路线:鹰蛾的超声波鸣叫
  • 批准号:
    1121739
  • 财政年份:
    2011
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant

相似海外基金

IntBIO Collaborative Research: Assessing drivers of the nitrogen-fixing symbiosis at continental scales
IntBIO 合作研究:评估大陆尺度固氮共生的驱动因素
  • 批准号:
    2316267
  • 财政年份:
    2023
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
IntBIO: Collaborative Research: Feedback between physiological performance and social foraging in multi-species social network of wintering birds
IntBIO:合作研究:越冬鸟类多物种社交网络中生理表现和社交觅食之间的反馈
  • 批准号:
    2316374
  • 财政年份:
    2023
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
IntBIO: Collaborative Research: Phenotypes of the Anthropocene: integrating the consequences of sensory stressors across biological scales
IntBIO:合作研究:人类世的表型:整合跨生物尺度的感觉压力源的后果
  • 批准号:
    2316364
  • 财政年份:
    2023
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
Collaborative Research: IntBIO: Micro level oxygen transport mechanisms in elite diving mammals: Capillary RBC to myofiber
合作研究:IntBIO:精英潜水哺乳动物的微水平氧运输机制:毛细血管红细胞到肌纤维
  • 批准号:
    2316378
  • 财政年份:
    2023
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
Collaborative Research: IntBIO: The Evolution of Immune Investment Strategies Across Amphibian Ontogeny
合作研究:IntBIO:跨两栖动物个体发育的免疫投资策略的演变
  • 批准号:
    2316469
  • 财政年份:
    2023
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
Collaborative Research: IntBIO: The Evolution of Immune Investment Strategies Across Amphibian Ontogeny
合作研究:IntBIO:跨两栖动物个体发育的免疫投资策略的演变
  • 批准号:
    2316468
  • 财政年份:
    2023
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
IntBIO Collaborative Research: Assessing drivers of the nitrogen-fixing symbiosis at continental scales
IntBIO 合作研究:评估大陆尺度固氮共生的驱动因素
  • 批准号:
    2316268
  • 财政年份:
    2023
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
IntBIO: Collaborative Research: Phenotypes of the Anthropocene: integrating the consequences of sensory stressors across biological scales
IntBIO:合作研究:人类世的表型:整合跨生物尺度的感觉压力源的后果
  • 批准号:
    2316363
  • 财政年份:
    2023
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
IntBIO: Collaborative Research: Integrating nanobiotechnologies to understand the role of nitro-oxidative stress in the coral-dinoflagellate mutualistic symbiosis dynamics
IntBIO:合作研究:整合纳米生物技术来了解硝基氧化应激在珊瑚-甲藻互利共生动态中的作用
  • 批准号:
    2316389
  • 财政年份:
    2023
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
Collaborative Research: IntBIO: Rules for cell membranes in the extremes of the deep sea
合作研究:IntBIO:深海极端条件下细胞膜的规则
  • 批准号:
    2316457
  • 财政年份:
    2023
  • 资助金额:
    $ 138.79万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了