SBIR Phase I: Safe control of herbicide-resistant weeds with a novel natural bioherbicide platform

SBIR 第一阶段：利用新型天然生物除草剂平台安全控制抗除草剂杂草

• 批准号: 2223639
• 负责人: Chad Brommer
• 金额: $ 27.49万
• 依托单位: HARPE BIOHERBICIDE SOLUTIONS, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2223639&HistoricalAwards=false
• 关键词: SBIR; Phase; Safe; control; herbicide

The broader/commercial impact of this Small Business Innovation Research (SBIR) Phase I project is in providing solutions to farmers who are facing the culmination of decades of herbicide resistant weed species evolving from applications of synthetic herbicides. Creation of herbicides which are effective, naturally produced, scalable, and deployed using the current agronomic practices could alter the foundations of crop production in the United States and around the world. In view of the projected 8% annual increase in global food and agriculture market, shrinking areas under cultivation that lead to the need for higher productivity per acre, and increasing demand for nutritional food items, the need for sustainable alternatives to current synthetic herbicides that do not promote herbicide resistant weeds is becoming clearer. Widespread adoption of the proposed technology is expected to benefit farmers and crop producers reducing societal strain, financial burden, and environmental stress from crop losses due to herbicide resistant weeds by eliminating these weeds through an environmentally safe method, without the use of excess fuel, time, equipment, and synthetic herbicides.The intellectual merit of this project is in developing a novel natural herbicide product that, when applied to herbicide resistant weeds, will cause seed or plant cell's membranes to degrade and lose integrity. Thus, the novel product is intended to work both as pre-emergent weed prevention and post-emergent weed control herbicide. The product will be an environmentally safe blend of natural plant extracts and excipients. The herbicide formulations will be sprayable onto soil or onto plant leaves and stems. The cost and time needed to initially screen herbicide rates, outcomes, and best practices typically is many years. The greenhouse screening approach takes months and provides valuable information to ensure that field trials, which are more expensive and impacted by changes in weather, are efficient in cost and outcomes. This project will initially focus on greenhouse validation of weed control of the most resistant weeds known in different geographical locations in the U.S. Dose response data for 50%-to-90% inhibition control/efficacy of herbicide resistant weeds will provide the information to develop a herbicide use label, directions for best practices, and good stewardship by using only the amount of herbicide needed for control without overuse.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这一小型企业创新研究(SBIR)第一阶段项目的更广泛/商业影响是为农民提供解决方案，这些农民正面临数十年因应用合成除草剂而进化出的抗除草剂杂草物种的顶峰。利用当前的农艺实践创造有效的、自然生产的、可推广的和使用的除草剂可能会改变美国和世界各地作物生产的基础。鉴于全球粮食和农业市场预计每年增长8%，种植面积缩小导致每英亩需要更高的生产率，以及对营养食品的需求不断增加，目前不促进抗除草剂杂草的合成除草剂的可持续替代品的必要性正变得越来越明显。这项拟议技术的广泛采用有望使农民和作物生产者受益，通过一种环境安全的方法消除这些杂草，而不需要使用多余的燃料、时间、设备和合成除草剂，从而减少因抗除草剂杂草而造成的作物损失所造成的社会压力、经济负担和环境压力。该项目的智力价值在于开发一种新型的天然除草剂产品，当应用于抗除草剂杂草时，将导致种子或植物细胞膜的降解和失去完整性。因此，这种新产品的目的是既作为紧急杂草预防，又作为紧急杂草控制后的除草剂。该产品将是一种环境安全的天然植物提取物和辅料的混合物。除草剂配方将可以喷洒到土壤或植物的叶子和茎上。最初筛选除草剂使用率、结果和最佳做法所需的成本和时间通常是多年的。温室筛选方法需要几个月的时间，并提供有价值的信息，以确保田间试验在成本和结果方面都是有效的，因为实地试验成本更高，受天气变化的影响也更大。该项目最初将专注于温室验证美国不同地理位置已知的最具抗性杂草的杂草控制。抗除草剂杂草50%至90%抑制控制/药效的剂量响应数据将提供信息，以开发除草剂使用标签、最佳实践方向和良好的管理，仅使用不过度使用所需的除草剂数量。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。