2022 Genomic Instability (GRS)-The Influence of Chromosome Architecture and Cell Cycle on Repair and Maintenance of the Genome

该奖项将为研究生和博士后研究人员参加2022年戈登基因组不稳定性研究研讨会（GRS）提供支持（2022年7月9日至10日在加州文图拉海滩举行）。GRS将在相关的戈登研究会议（GRC； 2022年7月10日至15日）之前举行。这两次会议汇集了来自多个学科的年轻和成熟的科学家，他们正在解决有关DNA修复和基因组维护的广泛问题，从工具开发到机制和功能。特别是，GRS使不同群体的早期职业科学家能够通过研讨会和海报会议讨论当前的研究，非正式地交流新的思想、技术和资源，并发展他们的专业网络。因此，这次会议将促进下一代科学家在这一迅速扩大的领域的培训和专业发展，包括代表性不足的少数民族。GRS计划包括与不同专业的有成就的科学家就职业选择进行小组讨论。GRS还为联合主席和组织者提供了职业发展经验，他们都是博士后。基因组的维持和稳定对细胞功能、稳定遗传和生物体表型至关重要。复杂的监测、信号和必要时的修复系统也很重要，因为它们的功能失调会导致一系列重要疾病。GRS和GRC为世界各地的研究人员分享他们最新的（通常未发表的）发现、讨论开创性的想法和开展新的合作提供了重要的联系。在生物化学，分子遗传学和DNA修复途径的细胞生物学的前沿主题将被覆盖，等等。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The award will provide support for graduate students and post-doctoral researchers to attend the 2022 Gordon Research Seminar (GRS) on Genome Instability (July 9-10, 2022 in Ventura Beach, CA). The GRS will be held just prior to the associated Gordon Research Conference (GRC; July 10-15, 2022). These two meetings bring together young and established scientists from multiple disciplines who are addressing a broad range of questions about DNA repair and genome maintenance, from tool development to mechanism and function. The GRS, in particular, enables a diverse group of early career scientists to discuss current research through seminars and poster sessions, exchange new ideas, technologies and resources informally, and develop their professional network. Hence this conference will facilitate training and professional development of the next generation of scientists in this rapidly expanding area, including underrepresented minorities. The GRS program includes a panel discussion on career choices with accomplished scientists in different professions. The GRS also serves as a career development experience for the co-chairs and organizers, who are postdocs. Genome maintenance and stability are essential to cellular function, stable inheritance, and organismal phenotype. The intricate monitoring, signaling and, when necessary, repair systems are also important because their dysfunction leads to a wide range of important diseases. The GRS and GRC serve as a vital link for investigators around the world to share their latest, often unpublished discoveries, discuss pioneering ideas and launch new collaborations. Topics at the forefront of biochemistry, molecular genetics and cell biology of DNA repair pathways will be covered, among others.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.