I-Corps: Commercialization of a real-time, palm-size, low-cost, and wireless SARS-COV-II detector

I-Corps：实时、手掌大小、低成本、无线 SARS-COV-II 探测器的商业化

• 批准号: 2230853
• 负责人: Zheng Tian
• 金额: $ 5万
• 依托单位: University of Arkansas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2230853&HistoricalAwards=false
• 关键词: Corps; Commercialization; real; time; palm

The broader impact/commercial potential of this I-Corps project is the development of a wireless nano-biosensor for detection of live coronavirus particles and potentially other pathogens. Currently, a positive result from an enzyme-linked immunosorbent assay (ELISA)- or polymerase chain reaction (PCR)-based COVID test does not determine if the coronavirus particles are live (infectious) or dead (or neutralized or noninfectious). The proposed technology is designed to detect interactions of live coronavirus particles with target cells, antibodies, and drugs in real-time. Those with a negative result from the proposed technology have confirmation that they are free of live, infectious coronavirus particles and would not need to quarantine. This technology may provide a tool for effectively combatting the COVID-19 virus and future pandemics/epidemics as well as other infections.This I-Corps project is based on the development of a nano-biosensing methodology for pathogen detection initially focused on SARS COV-II. The proposed technology integrates a bio-ceramic nanowire/graphene core/shell nanocomposite with a radio frequency identification (RFID) tag on a wireless communication chip surface. The hardware of the nano-biosensing system is composed of three parts: a radio frequency nano-sensor, a radio frequency reader, and a handheld device or smart phone. The proposed nano-biosensor is made by coating the biosafe nanocomposite on a disposable RFID tag to maximize the sensitivity. Further, nano-biosensors may be integrated to simultaneously detect samples in a multi-well plate, which is versatile and effective in the detection of virus particles, viral antigens, and antibodies, as well as in evaluating virus-neutralizing antibodies and vaccine efficacy.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目的更广泛的影响/商业潜力是开发一种无线纳米生物传感器，用于检测活的冠状病毒颗粒和潜在的其他病原体。目前，基于酶联免疫吸附测定（ELISA）或聚合酶链反应（PCR）的COVID检测的阳性结果不能确定冠状病毒颗粒是活的（传染性）还是死的（或中和或非传染性）。 该技术旨在实时检测活冠状病毒颗粒与靶细胞，抗体和药物的相互作用。那些从拟议的技术中获得阴性结果的人已经确认他们没有活的传染性冠状病毒颗粒，不需要隔离。该技术可能为有效对抗COVID-19病毒和未来的大流行/流行病以及其他感染提供工具。该I-Corps项目基于最初专注于SARS COV-II的病原体检测的纳米生物传感方法的开发。 所提出的技术将生物陶瓷纳米线/石墨烯核/壳纳米复合材料与无线通信芯片表面上的射频识别（RFID）标签集成。 纳米生物传感系统的硬件由三部分组成：射频纳米传感器、射频阅读器和手持设备或智能手机。所提出的纳米生物传感器是通过将生物安全纳米复合材料涂覆在一次性RFID标签上来最大化灵敏度。此外，纳米生物传感器可以集成到一个多孔板中，同时检测样品，这是通用的和有效的检测病毒颗粒，病毒抗原和抗体，以及评估病毒中和抗体和疫苗的效力。这个奖项反映了NSF的法定使命，并已被认为是值得支持的评估使用基金会的智力价值和更广泛的影响审查标准。