CAREER: Leveraging soil viromics to unravel ecological patterns in complex communities

职业:利用土壤病毒组学揭示复杂群落的生态模式

基本信息

  • 批准号:
    2236611
  • 负责人:
  • 金额:
    $ 89.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-01-15 至 2027-12-31
  • 项目状态:
    未结题

项目摘要

Soil microbes cycle nutrients that sustain plants, and these microbes are susceptible to viral infection. In the oceans, viruses kill up to 40% of microbial cells daily, impacting food webs and releasing nutrients. A teaspoon of soil can harbor thousands of viral species, but the role of viruses in soil remains a mystery. Little is known about which viruses are where, when, or why. This project will investigate how soil viral communities differ over space and time. The researchers will study how water content affects viral dynamics and how soil viral diversity is maintained. This work will require computational analyses of large datasets. A new ‘Bioinformatics for Biologists’ course will provide undergraduate students with hands-on training in these skills. The course will reach transfer students and other underrepresented groups in STEM, promoting the development of a diverse STEM workforce.This project will elucidate the spatiotemporal dynamics of soil viruses at the UC Davis Jepson Prairie Natural Reserve near Davis, CA. Using viromics (metagenomics of the viral size fraction), soil viral community biogeography and successional patterns will be compared within and across two grassland habitats that experience different amounts of mixing. The mystery of viral survival in seasonally dry soils will be explored to examine the roles of viral dormancy and seed banks in maintaining soil viral diversity. First, the researchers will establish local biogeographical patterns and evaluate the distance-decay relationship for soil viral communities in two grassland habitats. Next, they will compare intra- and inter-annual viral community successional patterns over space in dispersal-limited and well-mixed soils. Finally, they will apply a suite of DNA sequencing and experimental approaches to identify viruses in the cellular and acellular fractions of dry soils. This project will also pilot an undergraduate bioinformatics course, consisting of hands-on computational analysis modules co-led by teams of postdoctoral researchers. In addition to training and research opportunities for undergraduates, the course will facilitate pedagogical training for the postdoctoral instructors.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
土壤微生物循环维持植物的营养物质,这些微生物容易受到病毒感染。在海洋中,病毒每天杀死多达40%的微生物细胞,影响食物网并释放营养物质。一茶匙的土壤中可以藏匿数千种病毒,但病毒在土壤中的作用仍然是一个谜。关于哪些病毒在哪里、何时或为什么存在,我们知之甚少。该项目将研究土壤病毒群落在空间和时间上的差异。研究人员将研究含水量如何影响病毒动力学以及土壤病毒多样性如何维持。这项工作需要对大型数据集进行计算分析。一个新的“生物学家的生物信息学”课程将为本科生提供这些技能的实践培训。该课程将覆盖转学生和其他在STEM中代表性不足的群体,促进多元化STEM劳动力的发展。该项目将阐明加州大学戴维斯分校Jepson草原自然保护区附近的土壤病毒的时空动态。使用病毒组学(宏基因组学的病毒大小的分数),土壤病毒群落地理学和演替模式进行比较,并在两个草原栖息地,经历不同的混合量。病毒在季节性干燥土壤中存活的奥秘将被探索,以研究病毒休眠和种子库在维持土壤病毒多样性中的作用。首先,研究人员将建立当地的地理模式,并评估两个草原栖息地土壤病毒群落的距离衰减关系。接下来,他们将比较在扩散有限和混合良好的土壤中,病毒群落在空间上的年内和年际演替模式。最后,他们将应用一套DNA测序和实验方法来识别干燥土壤中细胞和非细胞组分中的病毒。该项目还将试点本科生生物信息学课程,包括由博士后研究人员团队共同领导的动手计算分析模块。除了为本科生提供培训和研究机会外,该课程还将促进博士后教师的教学培训。该奖项反映了NSF的法定使命,并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

项目成果

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Joanne Emerson其他文献

PATIENTS RECEIVING MECHANICAL VENTILATION
接受机械通气的患者
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    D. Strickland;Laura Tormey;K. Keane;S. Lubin;Joanne Emerson;S. Winfield;P. Dalby;Regina Townes;C. Sessler
  • 通讯作者:
    C. Sessler

Joanne Emerson的其他文献

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