The role of interleukin.6 (IL-6) and the interaction between IL-6 and interleukin-17 (IL-17) in the development of vascular inflammation and vascular dysfunction
白细胞介素 6 (IL-6) 的作用以及 IL-6 和白细胞介素 17 (IL-17) 之间的相互作用在血管炎症和血管功能障碍的发展中
基本信息
- 批准号:254025187
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2014
- 资助国家:德国
- 起止时间:2013-12-31 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Vascular dysfunction, also known as functional atherosclerosis, is associated with arterial hypertension and is based on a dysbalance of the oxidative and anti-oxidative systems in the vessel system, leading to increased levels of reactive oxygen species. The activation of NADPH-oxidases by angiotensin II is essential in this process, involving cells of the immune system, especially myelomonocytic cells (monocytes, macrophages, neutrophil granulocytes) which provide the phagocytic NADPH oxidase. For recruiting these cells and for the inflammatory cell-cell-interaction, inflammatory mediators such as cytokines are important. Of the later, interleukin-6 and interleukin-17 were shown to be of crucial relevance in vascular inflammatory mechanisms that lead to vascular dysfunction. How exactly these two cytokines lead to the development of vascular dysfunction remains unclear. As these cytokines potentially could offer a new point of attack for treatment options, their roles in the development of vascular dysfunction should be further analyzed and understood.In this grant proposal, our main objective is to examine the influence of interleukin-6 on the development of vascular dysfunction while paying special attention to the Interleukin-6 and interleukin-17 interaction and their impact on the macrophage and neutrophil recruitment to the vascular wall and their vascular infiltration.
血管功能障碍,也称为功能性动脉粥样硬化,与动脉高血压有关,其基础是血管系统中氧化和抗氧化系统的失衡,导致活性氧物种水平增加。在这个过程中,血管紧张素II激活NADPH-氧化酶是必不可少的,涉及免疫系统的细胞,特别是提供吞噬NADPH氧化酶的粒单核细胞(单核细胞、巨噬细胞、中性粒细胞)。对于这些细胞的招募和炎性细胞-细胞-细胞的相互作用,细胞因子等炎症介质是重要的。在后者中,白介素6和白介素17被证明在导致血管功能障碍的血管炎症机制中具有关键的相关性。这两种细胞因子究竟是如何导致血管功能障碍的尚不清楚。由于这些细胞因子可能为治疗方案提供新的攻击点,它们在血管功能障碍发展中的作用应该得到进一步的分析和理解。在这项拨款提案中,我们的主要目标是研究白细胞介素6在血管功能障碍发展中的影响,同时特别关注白细胞介素6和白细胞介素17的相互作用,以及它们对巨噬细胞和中性粒细胞募集到血管壁和它们的血管渗透的影响。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
T Cell-Derived IL-17A Induces Vascular Dysfunction via Perivascular Fibrosis Formation and Dysregulation of ·NO/cGMP Signaling
T 细胞衍生的 IL-17A 通过血管周围纤维化形成和 NO/cGMP 信号传导失调诱导血管功能障碍
- DOI:10.1155/2019/6721531
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Schuler R;Efentakis P;Wild J;Lagrange J;Garlapati V;Molitor M;Kossmann S;Oelze M;Stamm P;Schafer K;Munzel T;Daiber A;Waisman A;Wenzel P;Karbach SH
- 通讯作者:Karbach SH
Myeloid Cells to the Rescue: Improving Thrombus Resolution
骨髓细胞的救援:改善血栓溶解
- DOI:10.1055/s-0039-1701044
- 发表时间:2020
- 期刊:
- 影响因子:6.7
- 作者:Knopp T;Karbach S;Wenzel P.
- 通讯作者:Wenzel P.
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Privatdozentin Dr. Susanne Helena Karbach其他文献
Privatdozentin Dr. Susanne Helena Karbach的其他文献
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