Interleukin-6 (IL-6) receptor antibody therapy to malignant pleural mesothelioma

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Interleukin-6 (IL-6) is associated with rheumatoid arthritis. Tocilizumab (Actemra : a humanized anti-IL-6R antibody) is used for rheumatoid arthritis therapy. We investigated the effect of tocilizumab to malignant pleural mesothelioma. Tocilizumab suppressed malignant pleural mesothelioma cell growth and reductions were 10-25%. We compared the combination effect of pemetrexed, cisplatin and tocilizumab. The combination of pemetrexed, cisplatin and tocilizumab was more effective than any other two drugs combinations. We have already conformed the effect of MEK inhibitor. We checked the combination effect of tocilizumab and MEK inhibitor. The combination of tocilizumab and MEK inhibitor suppressed malignant pleural mesothelioma cell growth more than a single administration of MEK inhibitor. Tocilizumab reduced the phosho-Stat3 expression to 1/3-1/5. The combination of tocilizumab and MEK inhibitor reduced more the phosho-Stat3 expression.