ERASE-PFAS: Bottom-up synthesis of polymeric membranes for PFAS sequestration
ERASE-PFAS:自下而上合成用于 PFAS 封存的聚合物膜
基本信息
- 批准号:2246167
- 负责人:
- 金额:$ 42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-10-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Anti-corrosion and anti-stain coatings have been increasingly present in our daily lives facilitating the cleaning of objects and/or materials, slowing down material’s deterioration, and protecting them against chemical or thermal stress. Naturally, as these coatings increase in performance, they become more attractive to the public increasing demand, and thus driving forward their manufacture. One large class of molecules forming part of these coatings are the per- and polyfluoroalkyl substances (PFAS). Several thousands of PFAS have been identified, some of which are made in a very large scale. The inherent chemical properties of PFAS makes them essentially unbreakable when they leak into ecosystems. Unfortunately, the presence of PFAS in drinking water across the U.S. is now well-documented and human ingestion of PFAS has been associated with a number of diseases and cancer. The grand challenge ahead of us is to find ways of removing PFAS from the environment, especially when these substances contaminate drinking water sources. The goal of this project is to develop synthetic membranes capable of filtering water to remove the majority of the PFAS to well below the threshold of 70 parts-per-trillion, as established by the U.S. Environmental Protection Agency. Successful completion of the proposed research will develop the chemical pathways and basic understanding to create high-performing membranes to remove PFAS from water, ultimately with the goal of protecting public health. Additional benefits to society will be accomplished through education and training including the mentoring of two graduate students at Rice University.Per- and polyfluoroalkyl substances (PFAS) are molecules generally composed of 1) an anionic head group, carboxylate or sulfonate; and 2) a fluorinated backbone, which are incredibly resistant to environmental degradation. Their chemical and thermal stability made them ideal substances to use to protect materials from degrading or from events such as fires. Enormous quantities of FPAS were produced until health-related effects initiated the ban of certain species around the turn of the century. However, the large quantity that was produced coupled with their environmental persistence has resulted in widespread contamination of the environment, especially drinking water sources. Documented health risks posed by PFAS to humans include severe malformations in pregnant women, cancer in adults, liver malfunction, thyroid disease, decreased fertility, high cholesterol, and obesity. Given that PFAS have weak affinity and binding towards most chemical adsorbents, the challenge ahead is to design membranes capable of removing them from contaminated water. The overarching goal of this project is to design recognition sites for anionic PFAS, which will be later developed and incorporated into membranes used to filter water that would sequester long- and short-chain PFAS. To accomplish this central objective, the project will 1) design recognition sites embedded within supramolecular scaffolds; 2) synthesize, characterize, and determine the anion binding properties of the most promising scaffolds; and 3) polymerize the most promising architectures via olefinic and/or epoxide functional groups incorporated into the supramolecular scaffold, and test their PFAS sequestration properties in aqueous samples. The successful completion of this project will establish the fundamental parameters to enhance PFAS binding within molecular scaffolds to later translate this knowledge into the design of polymeric filtration materials. Education and outreach activities include creating seminars and hands-on workshops for high school and undergraduate students.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
防腐蚀和防污涂层已经越来越多地出现在我们的日常生活中,促进物体和/或材料的清洁,减缓材料的劣化,并保护它们免受化学或热应力的影响。当然,随着这些涂料性能的提高,它们对公众日益增长的需求变得更具吸引力,从而推动了它们的制造。形成这些涂层的一大类分子是全氟烷基和多氟烷基物质(PFAS)。已经确定了数千种PFAS,其中一些是大规模生产的。PFAS固有的化学性质使它们在泄漏到生态系统中时基本上不会破裂。不幸的是,PFAS在美国饮用水中的存在现已得到充分记录,人类摄入PFAS与许多疾病和癌症有关。我们面临的巨大挑战是找到从环境中去除PFAS的方法,特别是当这些物质污染饮用水源时。该项目的目标是开发能够过滤水的合成膜,以将大部分PFAS去除到远低于美国环境保护署确定的万亿分之70的阈值。成功完成拟议的研究将开发化学途径和基本的理解,以创建高性能的膜来去除水中的PFAS,最终以保护公众健康为目标。通过教育和培训,包括指导莱斯大学的两名研究生,还将实现对社会的额外惠益。全氟烷基和多氟烷基物质(PFAS)是通常由以下物质组成的分子:1)阴离子头基,羧酸盐或磺酸盐;和2)氟化骨架,它们对环境降解具有难以置信的抵抗力。它们的化学和热稳定性使其成为保护材料免受降解或火灾等事件影响的理想物质。在世纪之交,由于与健康有关的影响,开始禁止某些物种之前,生产了大量的FPAS。然而,由于生产量大,加上其环境持久性,造成了环境,特别是饮用水源的广泛污染。记录的PFAS对人类造成的健康风险包括孕妇严重畸形、成人癌症、肝功能障碍、甲状腺疾病、生育能力下降、高胆固醇和肥胖。考虑到PFAS对大多数化学吸附剂的亲和力和结合力较弱,未来的挑战是设计能够将其从污染水中去除的膜。该项目的总体目标是设计阴离子PFAS的识别位点,稍后将开发并纳入用于过滤水的膜中,以隔离长链和短链PFAS。为了实现这一中心目标,该项目将1)设计嵌入超分子支架内的识别位点; 2)合成,表征和确定最有前途的支架的阴离子结合特性; 3)通过将烯属和/或环氧官能团并入超分子支架来修饰最有前途的结构,并在水性样品中测试其PFAS螯合特性。该项目的成功完成将建立增强分子支架内PFAS结合的基本参数,以便将这些知识转化为聚合物过滤材料的设计。教育和推广活动包括为高中生和本科生举办研讨会和实践讲习班。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
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Raul Hernandez Sanchez其他文献
Raul Hernandez Sanchez的其他文献
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{{ truncateString('Raul Hernandez Sanchez', 18)}}的其他基金
ERASE-PFAS: Bottom-up synthesis of polymeric membranes for PFAS sequestration
ERASE-PFAS:自下而上合成用于 PFAS 封存的聚合物膜
- 批准号:
2226329 - 财政年份:2022
- 资助金额:
$ 42万 - 项目类别:
Standard Grant
CAREER: Tubularenes: A Novel Class of Conjugated Molecular Nanotubes
职业:管芳烯:一类新型共轭分子纳米管
- 批准号:
2302628 - 财政年份:2022
- 资助金额:
$ 42万 - 项目类别:
Continuing Grant
CAREER: Tubularenes: A Novel Class of Conjugated Molecular Nanotubes
职业:管芳烯:一类新型共轭分子纳米管
- 批准号:
2042423 - 财政年份:2021
- 资助金额:
$ 42万 - 项目类别:
Continuing Grant
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