Development of novel asymmetric domino reactions through the utilization of multiple transition metal catalysts cooperatively in one pot reactions

通过在一锅反应中协同利用多种过渡金属催化剂开发新型不对称多米诺反应

• 批准号: 254674877
• 负责人: Dr. Chuanjie Loh
• 金额: --
• 依托单位: Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/254674877?language=en
• 关键词: Development; novel; asymmetric; domino; reactions

This postdoctoral research involves the merging of multiple transition metal catalysts within a single reaction pot to effect multistep domino reactions enantioselectively. With the ever increasing cost and chemical waste generated due to traditional stepwise organic synthesis, the ability to improve the efficiency of reactions, especially those forming carbon carbon bonds through multicatalytic domino reactions within a one pot operation is increasingly gaining the attention of the scientific community. However, literature known multicatalytic systems are very limited and challenging since ligand specificity and specific functional group activation by the different metal catalysts in a time resolved domino fashion is pivotal in such systems. This research serves to develop novel strategies in this budding field of multi-metallic domino reactions by utilizing rhodium/gold or rhodium/palladium to effect orthogonal activation of different functional groups. It is envisaged that the successful implementation of this single pot multi-metallic domino strategy would allow much more efficient access into biologically and industrially interesting scaffolds enantioselectively.

这项博士后研究涉及将多个过渡金属催化剂合并到一个反应罐中，以实现多步多米诺反应的对映选择性。随着传统逐步有机合成的成本和产生的化学废物的不断增加，提高反应效率的能力，特别是那些在一锅操作中通过多催化多米诺骨牌反应形成碳碳键的反应，越来越受到科学界的关注。然而，文献中已知的多催化体系是非常有限和具有挑战性的，因为配体特异性和不同金属催化剂以时间分辨多米诺骨牌方式激活特定的官能团是此类体系的关键。这项研究旨在通过利用Rh/金或Rh/Pd来实现不同官能团的正交活化，从而在这一新兴的多金属多米诺反应领域开发新的策略。据设想，这一单一盆栽多金属多米诺骨牌战略的成功实施将使人们能够更有效地对映选择性地获得具有生物和工业意义的支架。