Studies of Catch and Release Behavior of Polyelectrolyte Brushes

聚电解质刷捕获和释放行为的研究

• 批准号: 2304838
• 负责人: Emmanuel Giannelis
• 金额: $ 55.16万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2304838&HistoricalAwards=false
• 关键词: Studies; Catch; Release; Behavior; Polyelectrolyte

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry (CHE) and the Polymers Program in the Division of Materials Research (DMR), Professor Christopher K. Ober of Cornell University will prepare and study model polymer brushes with carefully tailored capture-release properties. Polymer brushes are surface coatings made by growing individual polymer macromolecules from a surface and possess properties that can change over only a few nanometers from glass-like (a hard substrate) to tissue like (a soft, wet surface). Brushes make ideal materials as sampling systems for biological or environmental applications due to their large surface area. By capturing a target molecule we will concentrate to detect even small amounts of a chemical or biomolecule, and then once done, trigger release of the captured targets to enable reuse of our device. The goal is to understand the capture-release process to make resuable and more efficient sampling and detection systems. Characterization of these brush surfaces will include study of the capture-release mechanism as a function of brush architecture and binding site location and spacing on these new brushes. In these studies scientists in Germany and the United Kingdom will aid in characterizing the process and structure of these active polymer brushes. This work will offer a substantial training opportunity for students in Ithaca, New York that represents a cross-pollination between polymer chemistry and materials science while enabling them to take part in international collaborations and exchanges. Undergraduate researchers will work with the exchange partners to make and to study these materials. Outreach activities will include demonstrations designed for and made to high school teachers in teacher workshops of the value of nanochemistry in environmental and biological studies. This research is focused on the preparation and study of capture-release coil polymer brushes that have varying levels of binding sites with selected spacing along the backbone and in different positions of the side. Controlled radical polymerization will be used to create tailored narrow dispersity brushes in a single strand or bottle brush architecture based on acrylamide and styrene-maleimide polymers and peptoid precision synthesis will be employed to make brush side arms that enable precise placement of active sites. Alternating copolymerization will also space out binding sites and associated packing stress along the backbone and spacers will separate those sites from the backbone, both intended to maximize packing potential and control binding site distribution in the brushes. Different brush designs will be tested for capture-release applications through our Freiburg collaborators. Advanced characterization of the brushes will be made using analytical methods ranging from neutron reflectivity and GISAXS to fluorescence and QCM studies of brushes exposed to different binding systems. The research has a potential to highly impact the technological features such as selective binding, capture and release, grafted brush stability, and antifouling applications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系（CHE）和材料研究部（DMR）的大分子，超分子和纳米化学计划（CHE）和聚合物计划（DMR）的支持下，康奈尔大学的Christopher K. Ober教授将通过精心量身定制的捕获捕获的属性来准备和研究Polymer刷子。聚合物刷是通过从表面生长的单个聚合物大分子生长的表面涂层，并且具有从玻璃状（硬质基板）到像（柔软的湿表面）的组织中只能在几个纳米上变化的特性。刷子由于其较大的表面积而制造了理想的材料作为用于生物或环境应用的采样系统。通过捕获目标分子，我们将集中精力甚至检测少量的化学物质或生物分子，然后完成后，触发捕获的靶标释放以启用我们的设备。 目的是了解捕获释放过程，以制造可再生，更有效的采样和检测系统。这些刷子表面的表征将包括研究捕获释放机制作为刷子结构的函数以及绑定位点的位置以及在这些新刷子上的间距。在这些研究中，德国和英国的科学家将有助于表征这些活跃聚合物刷的过程和结构。这项工作将为纽约伊萨卡的学生提供大量培训机会，代表聚合物化学和材料科学之间的交叉授粉，同时使他们能够参加国际合作和交流。本科研究人员将与交流伙伴合作制作和研究这些材料。外展活动将包括为高中教师设计和进行纳米化学价值的教师讲习班的示威游行。这项研究的重点是对捕获释放的线圈聚合物刷的制备和研究，这些轴向聚合物刷具有不同水平的结合位点，沿骨架沿骨架和侧面的不同位置进行选择的间距。受控的自由基聚合将用于基于丙烯酰胺和苯乙烯 - 甲酰亚胺聚合物的单链或瓶刷结构来创建量身定制的窄性分散刷，并将使用肽精密的精确合成来制作刷子侧臂，以实现精确放置活性位点。交流共聚物还将沿骨干和垫片伸出结合位点和相关的填充应力，将这些位点与骨架分开，这均旨在最大化填料势和控制刷中的结合位点分布。不同的刷子设计将通过我们的Freiburg合作者进行测试，以获取捕获释放应用程序。将使用从中子反射率和gisaxs到暴露于不同结合系统的刷子的荧光和QCM研究等分析方法进行刷子的先进表征。这项研究具有高度影响技术特征的潜力，例如选择性结合，捕获和释放，移植的刷子稳定性和防污应用。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的智力优点和更广泛的影响来通过评估来支持的。