Studies of Catch and Release Behavior of Polyelectrolyte Brushes

聚电解质刷捕获和释放行为的研究

• 批准号: 2304838
• 负责人: Emmanuel Giannelis
• 金额: $ 55.16万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2304838&HistoricalAwards=false
• 关键词: Studies; Catch; Release; Behavior; Polyelectrolyte

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry (CHE) and the Polymers Program in the Division of Materials Research (DMR), Professor Christopher K. Ober of Cornell University will prepare and study model polymer brushes with carefully tailored capture-release properties. Polymer brushes are surface coatings made by growing individual polymer macromolecules from a surface and possess properties that can change over only a few nanometers from glass-like (a hard substrate) to tissue like (a soft, wet surface). Brushes make ideal materials as sampling systems for biological or environmental applications due to their large surface area. By capturing a target molecule we will concentrate to detect even small amounts of a chemical or biomolecule, and then once done, trigger release of the captured targets to enable reuse of our device. The goal is to understand the capture-release process to make resuable and more efficient sampling and detection systems. Characterization of these brush surfaces will include study of the capture-release mechanism as a function of brush architecture and binding site location and spacing on these new brushes. In these studies scientists in Germany and the United Kingdom will aid in characterizing the process and structure of these active polymer brushes. This work will offer a substantial training opportunity for students in Ithaca, New York that represents a cross-pollination between polymer chemistry and materials science while enabling them to take part in international collaborations and exchanges. Undergraduate researchers will work with the exchange partners to make and to study these materials. Outreach activities will include demonstrations designed for and made to high school teachers in teacher workshops of the value of nanochemistry in environmental and biological studies. This research is focused on the preparation and study of capture-release coil polymer brushes that have varying levels of binding sites with selected spacing along the backbone and in different positions of the side. Controlled radical polymerization will be used to create tailored narrow dispersity brushes in a single strand or bottle brush architecture based on acrylamide and styrene-maleimide polymers and peptoid precision synthesis will be employed to make brush side arms that enable precise placement of active sites. Alternating copolymerization will also space out binding sites and associated packing stress along the backbone and spacers will separate those sites from the backbone, both intended to maximize packing potential and control binding site distribution in the brushes. Different brush designs will be tested for capture-release applications through our Freiburg collaborators. Advanced characterization of the brushes will be made using analytical methods ranging from neutron reflectivity and GISAXS to fluorescence and QCM studies of brushes exposed to different binding systems. The research has a potential to highly impact the technological features such as selective binding, capture and release, grafted brush stability, and antifouling applications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系（CHE）的大分子，超分子和纳米化学计划以及材料研究系（DMR）的聚合物计划的支持下，Christopher K.康奈尔大学的Ober将制备和研究具有精心定制的捕获-释放特性的模型聚合物刷。聚合物刷是通过从表面生长单个聚合物大分子而制成的表面涂层，并且具有可以从玻璃状（硬基底）到组织状（软的、湿的表面）仅几纳米变化的性质。刷子由于其大的表面积而成为生物或环境应用的采样系统的理想材料。通过捕获目标分子，我们将集中检测即使是少量的化学或生物分子，然后一旦完成，触发捕获的目标的释放，以使我们的设备能够重复使用。 我们的目标是了解捕获-释放过程，以使采样和检测系统更有效。这些刷子表面的表征将包括作为刷子结构和结合位点位置和这些新刷子上的间距的函数的捕获-释放机制的研究。在这些研究中，德国和英国的科学家将帮助描述这些活性聚合物刷的过程和结构。这项工作将为纽约伊萨卡的学生提供大量的培训机会，这代表了聚合物化学和材料科学之间的交叉授粉，同时使他们能够参与国际合作和交流。本科研究人员将与交换伙伴合作制作和研究这些材料。外联活动将包括在教师讲习班上为高中教师设计和制作的示范，介绍纳米化学在环境和生物研究中的价值。本研究的重点是制备和研究的捕获-释放线圈聚合物刷，具有不同水平的结合位点，具有选定的间距沿着的骨干和在不同位置的侧。受控自由基聚合将用于在基于丙烯酰胺和苯乙烯-马来酰亚胺聚合物的单链或瓶刷结构中产生定制的窄分散度刷，并且拟肽精确合成将用于制造能够精确放置活性位点的刷侧臂。交替共聚还将使结合位点和相关的堆积应力沿着骨架间隔开，并且间隔物将使那些位点与骨架分离，两者都旨在使堆积潜力最大化并控制刷中的结合位点分布。我们的弗赖堡合作者将针对捕获-释放应用测试不同的画笔设计。先进的特性的刷子将使用分析方法，从中子反射率和GISAXS荧光和QCM研究暴露于不同的绑定系统的刷子。该研究有可能对选择性结合、捕获和释放、接枝刷稳定性和生物相容性应用等技术特征产生重大影响。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。