Studies of Catch and Release Behavior of Polyelectrolyte Brushes

聚电解质刷捕获和释放行为的研究

基本信息

  • 批准号:
    2304838
  • 负责人:
  • 金额:
    $ 55.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-01 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry (CHE) and the Polymers Program in the Division of Materials Research (DMR), Professor Christopher K. Ober of Cornell University will prepare and study model polymer brushes with carefully tailored capture-release properties. Polymer brushes are surface coatings made by growing individual polymer macromolecules from a surface and possess properties that can change over only a few nanometers from glass-like (a hard substrate) to tissue like (a soft, wet surface). Brushes make ideal materials as sampling systems for biological or environmental applications due to their large surface area. By capturing a target molecule we will concentrate to detect even small amounts of a chemical or biomolecule, and then once done, trigger release of the captured targets to enable reuse of our device. The goal is to understand the capture-release process to make resuable and more efficient sampling and detection systems. Characterization of these brush surfaces will include study of the capture-release mechanism as a function of brush architecture and binding site location and spacing on these new brushes. In these studies scientists in Germany and the United Kingdom will aid in characterizing the process and structure of these active polymer brushes. This work will offer a substantial training opportunity for students in Ithaca, New York that represents a cross-pollination between polymer chemistry and materials science while enabling them to take part in international collaborations and exchanges. Undergraduate researchers will work with the exchange partners to make and to study these materials. Outreach activities will include demonstrations designed for and made to high school teachers in teacher workshops of the value of nanochemistry in environmental and biological studies. This research is focused on the preparation and study of capture-release coil polymer brushes that have varying levels of binding sites with selected spacing along the backbone and in different positions of the side. Controlled radical polymerization will be used to create tailored narrow dispersity brushes in a single strand or bottle brush architecture based on acrylamide and styrene-maleimide polymers and peptoid precision synthesis will be employed to make brush side arms that enable precise placement of active sites. Alternating copolymerization will also space out binding sites and associated packing stress along the backbone and spacers will separate those sites from the backbone, both intended to maximize packing potential and control binding site distribution in the brushes. Different brush designs will be tested for capture-release applications through our Freiburg collaborators. Advanced characterization of the brushes will be made using analytical methods ranging from neutron reflectivity and GISAXS to fluorescence and QCM studies of brushes exposed to different binding systems. The research has a potential to highly impact the technological features such as selective binding, capture and release, grafted brush stability, and antifouling applications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在化学系(CHE)的大分子、超分子和纳米化学项目以及材料研究部(DMR)的聚合物项目的支持下,康奈尔大学的Christopher K. Ober教授将制备和研究具有精心定制的捕获-释放特性的模型聚合物刷。聚合物刷是一种表面涂层,通过在表面上生长单个聚合物大分子而制成,其特性可以在几纳米的范围内从玻璃状(坚硬的基材)转变为组织状(柔软潮湿的表面)。刷子由于表面积大,是生物或环境应用取样系统的理想材料。通过捕获目标分子,我们将集中检测即使是少量的化学或生物分子,然后一旦完成,触发释放捕获的目标,使我们的设备能够重复使用。目标是了解捕获-释放过程,以制作可重复使用且更有效的采样和检测系统。这些刷表面的表征将包括研究捕获-释放机制作为刷结构的功能,以及这些新刷上的结合位点位置和间距。在这些研究中,德国和英国的科学家将帮助表征这些活性聚合物刷的过程和结构。这项工作将为纽约伊萨卡的学生提供大量的培训机会,代表了聚合物化学和材料科学之间的交叉授粉,同时使他们能够参与国际合作和交流。本科生研究人员将与交换伙伴一起制作和研究这些材料。外展活动将包括在教师研讨会上为高中教师设计并向他们展示纳米化学在环境和生物研究中的价值。本研究的重点是制备和研究具有不同水平结合位点的捕获-释放线圈聚合物刷,这些结合位点沿主干和侧面的不同位置具有选定的间距。基于丙烯酰胺和苯乙烯-马来酰亚胺聚合物的可控自由基聚合将用于制造单链或瓶刷结构的量身定制的窄分散性刷子,肽类精密合成将用于制造能够精确放置活性位点的刷侧臂。交替共聚还会沿骨架分隔出结合位点和相关的填充应力,间隔剂会将这些位点与骨架分开,这都是为了最大限度地提高填充潜力并控制结合位点在刷中的分布。不同的笔刷设计将通过我们的弗莱堡合作者测试捕获-释放应用程序。将使用中子反射率和GISAXS分析方法,以及暴露于不同结合系统的刷的荧光和QCM研究等分析方法对刷进行高级表征。这项研究有可能对选择性结合、捕获和释放、接枝刷稳定性和防污应用等技术特性产生重大影响。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Emmanuel Giannelis其他文献

Emmanuel Giannelis的其他文献

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{{ truncateString('Emmanuel Giannelis', 18)}}的其他基金

I-Corps Sites - Type I: Cornell I-Corps Site
I-Corps 站点 - I 类:康奈尔 I-Corps 站点
  • 批准号:
    1644688
  • 财政年份:
    2017
  • 资助金额:
    $ 55.16万
  • 项目类别:
    Continuing Grant
PFI: Development of Lubricants and Battery Electrolytes From Nanoparticle Ionic Materials
PFI:利用纳米粒子离子材料开发润滑剂和电池电解质
  • 批准号:
    1114275
  • 财政年份:
    2011
  • 资助金额:
    $ 55.16万
  • 项目类别:
    Standard Grant
ACT/SGER: Nanohybrid Membranes for Fuel Cells
ACT/SGER:用于燃料电池的纳米混合膜
  • 批准号:
    0442223
  • 财政年份:
    2004
  • 资助金额:
    $ 55.16万
  • 项目类别:
    Standard Grant

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  • 批准号:
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  • 资助金额:
    25.0 万元
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