Studies of Catch and Release Behavior of Polyelectrolyte Brushes

聚电解质刷捕获和释放行为的研究

• 批准号: 2304838
• 负责人: Emmanuel Giannelis
• 金额: $ 55.16万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2304838&HistoricalAwards=false
• 关键词: Studies; Catch; Release; Behavior; Polyelectrolyte

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry (CHE) and the Polymers Program in the Division of Materials Research (DMR), Professor Christopher K. Ober of Cornell University will prepare and study model polymer brushes with carefully tailored capture-release properties. Polymer brushes are surface coatings made by growing individual polymer macromolecules from a surface and possess properties that can change over only a few nanometers from glass-like (a hard substrate) to tissue like (a soft, wet surface). Brushes make ideal materials as sampling systems for biological or environmental applications due to their large surface area. By capturing a target molecule we will concentrate to detect even small amounts of a chemical or biomolecule, and then once done, trigger release of the captured targets to enable reuse of our device. The goal is to understand the capture-release process to make resuable and more efficient sampling and detection systems. Characterization of these brush surfaces will include study of the capture-release mechanism as a function of brush architecture and binding site location and spacing on these new brushes. In these studies scientists in Germany and the United Kingdom will aid in characterizing the process and structure of these active polymer brushes. This work will offer a substantial training opportunity for students in Ithaca, New York that represents a cross-pollination between polymer chemistry and materials science while enabling them to take part in international collaborations and exchanges. Undergraduate researchers will work with the exchange partners to make and to study these materials. Outreach activities will include demonstrations designed for and made to high school teachers in teacher workshops of the value of nanochemistry in environmental and biological studies. This research is focused on the preparation and study of capture-release coil polymer brushes that have varying levels of binding sites with selected spacing along the backbone and in different positions of the side. Controlled radical polymerization will be used to create tailored narrow dispersity brushes in a single strand or bottle brush architecture based on acrylamide and styrene-maleimide polymers and peptoid precision synthesis will be employed to make brush side arms that enable precise placement of active sites. Alternating copolymerization will also space out binding sites and associated packing stress along the backbone and spacers will separate those sites from the backbone, both intended to maximize packing potential and control binding site distribution in the brushes. Different brush designs will be tested for capture-release applications through our Freiburg collaborators. Advanced characterization of the brushes will be made using analytical methods ranging from neutron reflectivity and GISAXS to fluorescence and QCM studies of brushes exposed to different binding systems. The research has a potential to highly impact the technological features such as selective binding, capture and release, grafted brush stability, and antifouling applications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系(CHE)的大分子、超分子和纳米化学项目和材料研究部(DMR)的聚合物项目的支持下，康奈尔大学的Christopher K.Ober教授将制备和研究具有精心定制的捕获-释放特性的聚合物刷子模型。聚合物刷子是由单个聚合物大分子从表面生长而成的表面涂层，具有从玻璃状(硬衬底)到组织状(软、湿表面)仅在几纳米内变化的特性。刷子具有很大的表面积，是生物或环境应用中理想的采样材料。通过捕获目标分子，我们将集中精力检测即使是少量的化学或生物分子，然后一旦完成，就会触发捕获的目标的释放，以使我们的设备能够重复使用。其目标是了解捕获-释放过程，以使采样和检测系统可重复使用和更有效。这些刷子表面的表征将包括研究作为刷子结构以及这些新刷子上结合位置和间距的函数的捕获-释放机制。在这些研究中，德国和英国的科学家将帮助确定这些活性聚合物刷子的工艺和结构。这项工作将为纽约伊萨卡的学生提供大量的培训机会，代表着聚合物化学和材料科学的交叉授粉，同时使他们能够参与国际合作和交流。本科生研究人员将与交换伙伴一起制作和研究这些材料。外联活动将包括在教师讲习班上为高中教师设计并向他们展示纳米化学在环境和生物研究中的价值。本研究的重点是制备和研究捕获-释放线圈聚合物刷子，这种刷子具有沿主干和侧面不同位置具有不同水平的选择间距的结合位置。受控自由基聚合将用于在基于丙烯酰胺和苯乙烯-马来酰亚胺聚合物的单链或瓶刷结构中创建量身定制的窄分散刷子，并将采用类肽精密合成来制造刷子侧臂，使活性部位能够精确放置。交替的共聚还将沿着主干隔开结合部位和相关的堆积应力，而间隔物将这些部位与主干分开，两者的目的都是为了最大限度地提高堆积潜力并控制结合部位在刷子中的分布。不同的电刷设计将通过我们的弗莱堡合作者对捕获-释放应用程序进行测试。将使用分析方法对刷子进行高级表征，范围从中子反射率和GISAXS到暴露在不同结合系统中的刷子的荧光和QCM研究。这项研究有可能极大地影响技术特征，如选择性结合、捕获和释放、嫁接刷子的稳定性和防污应用。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。