Iterative Macromolecular Functionalization
迭代大分子功能化
基本信息
- 批准号:2304952
- 负责人:
- 金额:$ 51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-01 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
With the support of the Macromolecular, Supramolecular and Nanochemistry program in the Division of Chemistry, Rebekka Klausen of Johns Hopkins University is developing a single synthetic platform that will access macromolecules that cannot be made by direct polymerization of traditional feedstocks. Chemical transformations will first be utilized to prepare polymers and copolymers containing carbon-boron bond along the main backbone. The synthesized macromolecules will then be diversified by converting these bonds to corresponding alcohols, chlorides and simple alpha-olefins. The synthesis of these historically inaccessible polymers is expected to uncover new structure-function relationships and enable systematic evaluation of physical, mechanical, and chemical properties of these systems. Additionally, since the prepared polymers will contain polar and nonpolar functionalities, improved adhesion and oxygen permeability is expected. Both properties are very important in several applications or relevance to commercial plastics. The involvement in the Summer Undergraduate Research Excellence (SURE) program between Johns Hopkins University and Trinity Washington University, a minority-serving institution and women’s college in Washington, DC, will enable training of minority and first-generation undergraduate students in polymer science research. Additional outreach and educational activities related to polymer science and sustainability will be conducted at a college preparatory high school with a diverse student body in Olney, Maryland.This project will focus on the development of new polymer modification chemistries using borane-substituted polyolefins as precursors to access (co)polymers that are otherwise difficult to obtain. Specifically, the synthesis of copolymers that are formally derived from allylic monomers such as allyl chloride and allyl alcohol, as well as propene, will be conducted using Matteson homologation followed by hydrogenative, oxidative, and/or chlorinative deborylation. The insertion of a methylene or chloromethyl group into a carbon–boron bond via Matteson homologation is a particularly compelling application of organoborane chemistry because it can be applied iteratively and stereospecifically, while yielding few byproducts. This research is targeting (co)polymers of allyl alcohol, allyl chloride, and alpha-olefins; polymers that are elusive and highly desired materials that cannot be accessed directly from polymerization of allylic monomers due to competitive chain transfer, catalyst poisoning, or mismatched reactivity ratios. Polymers synthesized as a result of this work is anticipated to open up new chemical space for systematic structure-property studies of relevance to the synthetic organic and polymer communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在化学系大分子,超分子和纳米化学项目的支持下,约翰霍普金斯大学的Rebekka Klausen正在开发一个单一的合成平台,该平台将获得无法通过传统原料直接聚合制成的大分子。 化学转化将首先用于制备沿主链沿着含有碳-硼键的聚合物和共聚物。 然后,通过将这些键转化为相应的醇、氯化物和简单的α-烯烃,使合成的大分子多样化。 这些历史上难以接近的聚合物的合成有望揭示新的结构-功能关系,并使这些系统的物理,机械和化学性质的系统评价。此外,由于制备的聚合物将含有极性和非极性官能团,因此预期改善的粘合性和透氧性。 这两种性能在几种应用中或与商业塑料相关的应用中都非常重要。 参与约翰霍普金斯大学和华盛顿Trinity大学之间的夏季本科生卓越研究(SURE)计划,该大学是一所少数民族服务机构,也是华盛顿的女子学院,将使少数民族和第一代本科生能够接受聚合物科学研究的培训。 在马里兰州奥尔尼的一所大学预科高中,将开展与聚合物科学和可持续性相关的其他推广和教育活动。该项目将侧重于开发新的聚合物改性化学品,使用硼烷取代的聚烯烃作为前体,以获得难以获得的(共)聚合物。具体地,形式上衍生自烯丙基单体如烯丙基氯和烯丙醇以及丙烯的共聚物的合成将使用Matteson同系化,然后进行氢化、氧化和/或氯化脱硼化。 通过马特森同系作用将亚甲基或氯甲基插入碳-硼键中是有机硼烷化学的一个特别引人注目的应用,因为它可以反复和立体特异性地应用,同时产生很少的副产物。 这项研究的目标是烯丙醇,烯丙基氯和α-烯烃的(共)聚合物;由于竞争性链转移,催化剂中毒或不匹配的竞聚率,这些聚合物是难以捉摸的和高度期望的材料,无法直接从烯丙基单体的聚合中获得。作为这项工作的结果,合成的聚合物预计将开辟新的化学空间,为系统的结构-性能研究的相关性合成有机和聚合物community.This奖项反映了NSF的法定使命,并已被认为是值得支持的评估使用基金会的知识价值和更广泛的影响审查标准。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rebekka Klausen其他文献
Rebekka Klausen的其他文献
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{{ truncateString('Rebekka Klausen', 18)}}的其他基金
MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer and Equipped with Solid-State Probes
MRI:购买 500 MHz 核磁共振 (NMR) 波谱仪并配备固态探针
- 批准号:
2018176 - 财政年份:2020
- 资助金额:
$ 51万 - 项目类别:
Standard Grant
CAREER: Hydrophilic and Hydrophobic Polymers from Boron-Containing Polyolefins
职业:含硼聚烯烃的亲水性和疏水性聚合物
- 批准号:
1752791 - 财政年份:2018
- 资助金额:
$ 51万 - 项目类别:
Continuing Grant
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