NSF PRFB FY23: Cross-species gene regulation of a plant-fungal symbiosis under environmental stress

NSF PRFB FY23:环境胁迫下植物-真菌共生的跨物种基因调控

基本信息

  • 批准号:
    2305481
  • 负责人:
  • 金额:
    $ 24万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Fellowship Award
  • 财政年份:
    2024
  • 资助国家:
    美国
  • 起止时间:
    2024-03-01 至 2027-02-28
  • 项目状态:
    未结题

项目摘要

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2023, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment, and Phenotypes. The fellowship supports research and training of the fellow that will contribute to the area of Rules of Life in innovative ways. About 75% of all land plants partner with just one type of fungus, "arbuscular mycorrhizal fungi". This relationship shapes how plants get nutrients and how whole ecosystems function. Whether this relationship is useful for plants depends on environmental factors like nutrient availability. For example, fungi often help plants when nutrients are scarce, but can harm plants when plants can easily get nutrients on their own. Unfortunately, the genes that control when this relationship harms or helps plants are not well-known. Knowing which genes determine when fungi benefit plants will be vital to using fungi in agriculture and biodiversity efforts. The fellow will use large gene surveys, greenhouse experiments, and microscopy to explore how plants and fungi impact each other’s genes under different conditions. The fellow also proposes broadening participation in biology by continuing to mentor students from diverse backgrounds and organizing career development seminars for students. These seminars will provide necessary knowledge for applying to careers in STEM.The fellow will identify genetic regulation occurring across species (i.e., plant genes that regulate fungal genes and vice versa) to understand how plants and fungi co-regulate their relationship in different environmental conditions. The fellow will satisfy this objective in three aims: 1) the fellow will explore how environmental stress reorganizes co-expression patterns of plant and fungal genes using gene co-expression networks, 2) the fellow will use plant growth assays of the model legume Medicago trunculata missing potentially important regulatory genes (i.e., genes with many connections in the above networks) with/without arbuscular mycorrhizal fungi under different stresses, and, lastly, 3) the fellow will grow Medicago truncatula with 19 different characterized fungal isolates to explore how genetic/functional diversity of fungal partners impacts context-dependency of plant-mycorrhizal associations. Through the completion of this project and working closely with Drs. John Stinchcombe and Vasilis Kokkoris, the fellow will: 1) refine his training in next-generation sequencing and multivariate statistics, 2) gain skills in fungal biology and fungal assays, and 3) develop as a mentor through teaching biology courses and developing courses through his professional development seminar series.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该行动资助了美国国家科学基金会2023财年生物学博士后研究奖学金,研究基因组,环境和表型之间相互作用的生命规则的综合研究。该奖学金支持将以创新方式对生活规则领域作出贡献的研究员的研究和培训。大约75%的陆地植物只与一种真菌“丛枝菌根真菌”共生。这种关系决定了植物如何获取营养以及整个生态系统如何运作。这种关系是否对植物有用取决于环境因素,如养分有效性。例如,真菌通常在营养缺乏时对植物有益,但当植物自己很容易获得营养时,真菌就会伤害植物。不幸的是,控制这种关系对植物有害或有益的基因并不为人所知。了解哪些基因决定真菌何时对植物有益,对于在农业和生物多样性工作中利用真菌至关重要。他将使用大型基因调查、温室实验和显微镜来探索植物和真菌在不同条件下如何相互影响基因。他还建议继续指导来自不同背景的学生,并为学生组织职业发展研讨会,以扩大对生物学的参与。这些研讨会将提供应用STEM职业所需的知识。该研究员将识别跨物种发生的遗传调节(即,植物基因调节真菌基因,反之亦然),以了解植物和真菌如何在不同的环境条件下共同调节它们的关系。研究员将在三个方面实现这一目标:1)研究环境胁迫如何利用基因共表达网络重组植物和真菌基因的共表达模式;2)研究人员将对缺少潜在重要调控基因(即在上述网络中有许多连接的基因)的模式豆科植物紫花苜蓿(Medicago trunculata)在不同胁迫下与丛枝菌根真菌一起或不一起进行植物生长分析;3)该研究人员将与19种不同的特征真菌分离株一起种植紫花苜蓿,以探索真菌伴侣的遗传/功能多样性如何影响植物-菌根关联的环境依赖性。通过这个项目的完成和与博士的密切合作。John Stinchcombe和Vasilis Kokkoris,研究员将:1)完善他在下一代测序和多元统计方面的培训,2)获得真菌生物学和真菌分析方面的技能,3)通过教授生物学课程和通过他的专业发展系列研讨会开发课程来发展为导师。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Damian Hernandez其他文献

Abstract WMP78: Prostaglandin D2 DP1 Receptor Attenuates the Effects of Post-stroke Sleep Disturbance on Stroke Outcomes
摘要 WMP78:前列腺素 D2 DP1 受体减弱中风后睡眠障碍对中风结果的影响
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    A. Ahmad;P. Kamat;Damian Hernandez;S. Doré
  • 通讯作者:
    S. Doré

Damian Hernandez的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

相似海外基金

NSF PRFB FY23: Effects of bioengineering on community assembly and ecosystem functioning in a soil microbial community
NSF PRFB FY23:生物工程对土壤微生物群落的群落组装和生态系统功能的影响
  • 批准号:
    2305961
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY23: Understanding the evolutionary importance and vectoring mechanisms of horizontal gene transfer within a parasitic plant system
NSF PRFB FY23:了解寄生植物系统内水平基因转移的进化重要性和矢量机制
  • 批准号:
    2305877
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY23: Linking genotypes, phenotypes, and ecology to elucidate the origins of parasite resistance
NSF PRFB FY23:将基因型、表型和生态学联系起来,阐明寄生虫抗性的起源
  • 批准号:
    2305974
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY23: Methylation and microbes as moderators of genotype-by-environment interactions
NSF PRFB FY23:甲基化和微生物作为基因型与环境相互作用的调节剂
  • 批准号:
    2305978
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY23: Polyploidy as a driver of developmental and morphological evolution
NSF PRFB FY23:多倍体作为发育和形态进化的驱动力
  • 批准号:
    2305732
  • 财政年份:
    2023
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY23: Dissecting the holobiont: exploring how genetics, environments, and microbiomes contribute to emergent host phenotypes
NSF PRFB FY23:剖析全生物:探索遗传学、环境和微生物组如何促进新兴宿主表型
  • 批准号:
    2305704
  • 财政年份:
    2023
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY23: Host-pathogen dynamics in response to resource pulses: nutrients, immunity and disease transmission
NSF PRFB FY23:响应资源脉冲的宿主病原体动态:营养、免疫和疾病传播
  • 批准号:
    2305798
  • 财政年份:
    2023
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY23: Temperature effects on community assembly: a case study in nectar microbes of a western north American native plant
NSF PRFB FY23:温度对群落聚集的影响:北美西部本土植物花蜜微生物的案例研究
  • 批准号:
    2305992
  • 财政年份:
    2023
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY23: Deciphering the relationship between host convergent evolution, division of labor, and microbiome assembly within the honeypot ant system
NSF PRFB FY23:破译蜜罐蚂蚁系统内宿主趋同进化、劳动分工和微生物组组装之间的关系
  • 批准号:
    2305685
  • 财政年份:
    2023
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY23: Heritable viruses as hidden drivers of host phenotypes: Densoviruses and aphid wing plasticity
NSF PRFB FY23:遗传病毒作为宿主表型的隐藏驱动因素:浓核病毒和蚜虫翅膀可塑性
  • 批准号:
    2305653
  • 财政年份:
    2023
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了