NSF PRFB FY 2023: Investigating enhancer and protein divergence at follistatin paralogs underlying genetic assimilation of wing plasticity

NSF PRFB 2023 财年:研究卵泡抑素旁系同源物的增强子和蛋白质差异,这些是翅膀可塑性遗传同化的基础

基本信息

  • 批准号:
    2305817
  • 负责人:
  • 金额:
    $ 24万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Fellowship Award
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-06-01 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2023, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment, and Phenotypes. The fellowship supports research and training of the fellow that will contribute to the area of Rules of Life in innovative ways. Today's diversity of plant and animal forms observable in nature arises from accumulated morphological innovations. Despite the scientific interest in this topic, the evolutionary processes that give rise to new forms are still surrounded by mystery and debate. One promising model is genetic assimilation, in which new forms that have emerged from environmentally induced variation (phenotypic plasticity), can later become genetically determined. However, it remains unclear how such a switch from environmental to genetic control might occur. This project aims to characterize the molecular mechanisms facilitating genetic assimilation, to further our understanding of morphological novelty, diversity, and evolution. As a study system, the fellow will utilize the pea aphid, in which a female form variation has been genetically assimilated in males by changes in their DNA. Pea aphids produce two types of wingless morphs: asexual wingless females induced by maternal environment (wing polyphenism, a type of phenotypic plasticity), and genetically determined wingless males (genetic assimilation). Importantly, the shorthand term "wingless" used here describes not only a loss of wings, but a systemic change in metabolic, behavioral, and multiple morphological character states. Thus, "wingless" pea aphid morphs comprise a bona fide example of phenotypic novelty. Two duplicates of the gene follistatin (fs), a TGF-beta ligand inhibitor, are separately involved in male and female wingless morph determination. The duplicate fs2 is upregulated in wingless females, while the presence of the fs3 duplicate determines wingless male morphs. Both duplicates exhibit changes to their protein coding and putative regulatory regions. The fellow will use cutting edge experimental techniques to characterize changes in cis-regulation (Aim 1), signatures of selection (Aim 2), and protein function (Aim 3) at fs paralogs, to determine how duplication and divergence facilitated genetic assimilation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这项行动资助了2023财年的NSF生物学博士后研究奖学金,综合研究调查了基因组,环境和表型之间的生命管理相互作用的规则。该研究金支持研究员的研究和培训,以创新的方式为生活规则领域做出贡献。今天在自然界中可观察到的植物和动物形式的多样性来自于积累的形态创新。尽管科学界对这一主题很感兴趣,但产生新形式的进化过程仍然充满了神秘和争论。一个有希望的模式是遗传同化,在这种模式中,由环境诱导的变异(表型可塑性)产生的新形式后来可以由遗传决定。然而,目前还不清楚这种从环境控制到遗传控制的转变是如何发生的。该项目旨在描述促进遗传同化的分子机制,以进一步了解形态学的新奇,多样性和进化。作为一个研究系统,该研究员将利用豌豆蚜虫,其中雌性形式的变异已经通过DNA的变化在雄性中遗传同化。豌豆蚜虫产生两种类型的无翅变种:由母体环境诱导的无性无翅雌性(翅多型,一种表型可塑性)和遗传决定的无翅雄性(遗传同化)。重要的是,这里使用的简写术语“无翅”不仅描述了翅膀的损失,而且描述了代谢,行为和多种形态特征状态的系统性变化。因此,“无翅”豌豆蚜虫变体包括表型新奇的真正实例。两个重复的基因卵泡抑素(fs),TGF-β配体抑制剂,分别参与男性和女性无翅形态的决定。重复fs 2在无翅雌性中上调,而fs 3重复的存在决定了无翅雄性的形态。这两个重复显示其蛋白质编码和推定的调控区的变化。该研究员将使用尖端的实验技术来表征fs旁系同源物的顺式调节(Aim 1)、选择特征(Aim 2)和蛋白质功能(Aim 3)的变化,以确定复制和分歧如何促进遗传同化。该奖项反映了NSF的法定使命,并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Kevin Deem其他文献

Kevin Deem的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

相似海外基金

NSF PRFB FY 2023: Considering evolutionary responses to temperature variability when predicting risk to climate change and disease in amphibians
NSF PRFB 2023 财年:在预测气候变化和两栖动物疾病风险时考虑对温度变化的进化反应
  • 批准号:
    2305659
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY 2023: Impact of Environment-Seagrass-Microbe Interactions on Seagrass Stress Response and Ecosystem Functions
NSF PRFB 2023 财年:环境-海草-微生物相互作用对海草应激反应和生态系统功能的影响
  • 批准号:
    2305691
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY 2023: Multi-omics Assessment of Translocation Impacts on Sonoran Pronghorn
NSF PRFB 2023 财年:对索诺兰叉角羚易位影响的多组学评估
  • 批准号:
    2305938
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY 2023: Assessing morphological, behavioral, and genetic impacts of methylmercury on spiders.
NSF PRFB 2023 财年:评估甲基汞对蜘蛛的形态、行为和遗传影响。
  • 批准号:
    2305949
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY 2023: Thermoregulatory evolution of hummingbirds: Using urban heat islands as a globally replicated natural experiment
NSF PRFB 2023 财年:蜂鸟的体温调节进化:利用城市热岛作为全球复制的自然实验
  • 批准号:
    2305367
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY 2023: The evolutionary drivers of iridescence
NSF PRFB 2023 财年:彩虹色的进化驱动因素
  • 批准号:
    2305911
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY 2023: Investigating environmental and genomic regulation of molt in birds
NSF PRFB 2023 财年:研究鸟类蜕皮的环境和基因组调控
  • 批准号:
    2305971
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY 2023: Connecting physiological and cellular aging to individual quality in a long-lived free-living mammal.
NSF PRFB 2023 财年:将生理和细胞衰老与长寿自由生活哺乳动物的个体质量联系起来。
  • 批准号:
    2305890
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY 2023: Understanding the ecological drivers and genomic mechanisms of wildlife viral emergence caused by deforestation in Cambodia
NSF PRFB 2023 财年:了解柬埔寨森林砍伐导致野生动物病毒出现的生态驱动因素和基因组机制
  • 批准号:
    2303760
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
NSF PRFB FY 2023: Heritable phenotypes and mechanisms through transgenerational plasticity in response to hypoxia in fish
NSF PRFB 2023 财年:通过跨代可塑性响应鱼类缺氧的遗传表型和机制
  • 批准号:
    2305837
  • 财政年份:
    2024
  • 资助金额:
    $ 24万
  • 项目类别:
    Fellowship Award
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了