NSF PRFB FY 2023: The impact of changes in genome structure on diversification in adaptive radiation.

NSF PRFB 2023 财年：基因组结构变化对适应性辐射多样化的影响。

• 批准号: 2305927
• 负责人: Inbar Maayan
• 金额: $ 24万
• 依托单位: Maayan, Inbar
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-10-01 至 2026-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2305927&HistoricalAwards=false
• 关键词: NSF; PRFB; FY; 2023; impact

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2023, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment, and Phenotypes. The fellowship supports research and training of the fellow that will contribute to the area of Rules of Life in innovative ways. The aim of this project is to examine how changes in genetic organization can interfere with reproduction and fast-track adaptation to the environment, driving the evolution of animal diversity. The Fellow will use genome sequencing, chromosome mapping, and comparison of patterns of DNA change among North American lizards to study how chromosome changes may initiate divergence between groups even when those groups are found in the same place. In doing so, this work will illuminate how biodiversity arises and is maintained, findings that are particularly urgent in this age of biodiversity loss and global change. Through engagement with students at the Fellow’s host institution and while conducting fieldwork, this work will also help to expand avenues for participation in science for people of all backgrounds.A major gap in our understanding of speciation concerns the mechanisms that initially disrupt gene flow among adaptively-diverging lineages. This project will shed new light on this question by investigating the role that changes in genome organization may play as early drivers of speciation during adaptive radiation. Over the course of this project, the Fellow will generate high-quality reference genomes, apply synteny mapping and cytogenetic techniques to detect signatures of structural changes, and test for evidence of selection and shifts in evolutionary rates. This work will focus on a clade within Anolis lizards as a case study to uncover general principles governing major bursts of diversification as standing genetic variation becomes exposed to different selection regimes through chromosomal fission and fusion. While carrying out this project, the Fellow will receive training in the methods involved with the aims of the study and expand access to scientific training for students through both research mentorship and institution-based programs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该行动资助了2023财年NSF生物学博士后研究奖学金，即研究基因组、环境和表型之间相互作用的生命规则的综合研究。该研究金支持研究员的研究和培训，以创新的方式为生活规则领域做出贡献。该项目的目的是研究遗传组织的变化如何干扰繁殖和快速适应环境，推动动物多样性的进化。该研究员将使用基因组测序，染色体定位和北美蜥蜴DNA变化模式的比较，研究染色体变化如何可能引发群体之间的分歧，即使这些群体被发现在同一个地方。在这样做的过程中，这项工作将阐明生物多样性是如何产生和维持的，在这个生物多样性丧失和全球变化的时代，这些发现尤其紧迫。通过与研究员所在机构的学生接触并进行实地考察，这项工作也将有助于扩大所有背景的人参与科学的途径。我们对物种形成的理解中的一个主要差距是最初破坏适应性分化谱系之间基因流动的机制。该项目将通过研究基因组组织的变化可能在适应性辐射期间作为物种形成的早期驱动因素发挥的作用，为这个问题提供新的线索。在这个项目的过程中，研究员将生成高质量的参考基因组，应用同线性映射和细胞遗传学技术来检测结构变化的特征，并测试选择和进化速率变化的证据。这项工作将集中在阿诺利斯蜥蜴的一个分支作为案例研究，揭示了一般原则，管理的主要突发多样化的常设遗传变异成为暴露于不同的选择制度，通过染色体裂变和融合。在开展该项目的同时，研究员将接受与研究目标相关的方法培训，并通过研究指导和机构计划扩大学生获得科学培训的机会。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。