Discovering How Stress Induced Histomorphogenesis Effects the Long-term Leaching from an Implanted Medical Device using Phase Field Models

使用相场模型发现应力诱导的组织形态发生如何影响植入医疗器械的长期浸出

• 批准号: 2309538
• 负责人: Martin Tanaka
• 金额: $ 19.98万
• 依托单位: Western Carolina University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2309538&HistoricalAwards=false
• 关键词: Discovering; How; Stress; Induced; Histomorphogenesis

This project will use computer simulations to better understand the effects of a medical implant on the surrounding tissue. Many people benefit from implanted medical devices to restore body function caused by injury, disease, cancer, or aging. Plastics and other polymers are commonly used in hip implants, knee implants, and coatings around these devices. This could cause harm if potentially hazardous chemicals within them leach into the body. Existing computer simulations can be used to predict the amount of material released from a device for short-term exposure. However, these models cannot accurately capture long-term exposure because they do not consider changes in the tissue that occur during the healing process. This award supports fundamental research to provide knowledge needed to generate computer simulations that account for tissue changes near an implanted device. Outcomes include developing a better understanding of how these changes impact tissue permeability and may contribute to the assessment of the risk posed by medical devices. In addition, this research will further enhance our understanding of transport properties in biological tissue, support three high priority regulatory science projects, and provide undergraduates with funded research opportunities.Phase field modeling is a powerful technique that can be used to model heterogeneous materials that change phase over space and time. The characteristics of an individual element are identified by field parameters that enable individual elements to evolve over time, giving a single model the ability to effectively capture complex time-dependent behavior. It was selected for this study because of its ability to model the transformation of tissue from regular preimplantation phenotypes to fibrous and avascular tissue associated with the foreign body capsule. Because the element characteristics are controlled by the field and not permanently associated with specific elements, the boundary location between different tissue phenotypes can move as healing progresses and a single-phase field model can capture both the histomorphological changes and the biotransport properties of the system through the entire duration of the healing process. This work will be the first application of phase field modeling to characterize the evolution of the complex heterogeneous tissue structure surrounding an implanted medical device. Furthermore, it will also be the first model that quantifies the release of leachable chemicals by an implant through heterogeneous tissues.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目将使用计算机模拟来更好地了解医疗植入物对周围组织的影响。许多人受益于植入的医疗设备，以恢复因受伤、疾病、癌症或衰老而导致的身体功能。塑料和其他聚合物通常用于髋关节植入物、膝盖植入物以及这些设备周围的涂层。如果它们体内的潜在危险化学物质渗入人体，这可能会造成伤害。现有的计算机模拟可以用来预测设备在短期曝光时释放的材料数量。然而，这些模型不能准确地捕捉长期暴露，因为它们没有考虑愈合过程中发生的组织变化。该奖项支持基础研究，以提供产生计算机模拟所需的知识，以解释植入设备附近的组织变化。结果包括更好地了解这些变化如何影响组织通透性，并可能有助于评估医疗器械构成的风险。此外，这项研究还将进一步加深我们对生物组织中输运性质的理解，支持三个高度优先的调控科学项目，并为本科生提供资助的研究机会。相场建模是一种强大的技术，可用于模拟随时间和空间变化的非均质材料。单个元素的特征由字段参数标识，这些参数使单个元素能够随时间演变，从而使单个模型能够有效地捕获复杂的时间相关行为。之所以选择它进行这项研究，是因为它能够模拟组织从常规植入前表型到与异物包膜相关的纤维和无血管组织的转变。由于元素特征受场控制，并不与特定元素永久关联，不同组织表型之间的边界位置可以随着愈合过程的进展而移动，单相场模型可以在整个愈合过程中捕捉系统的组织形态变化和生物运输属性。这项工作将是第一次应用相场建模来表征植入式医疗设备周围复杂的异质组织结构的演变。此外，它还将是第一个量化植入物通过异种组织释放可浸出化学物质的模型。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。