Structural and cellular characterization of bone marrow interfaces under the influence of adi-pogen factors in bone replacement material testing ((16) B11)

在B11中，脂肪因子和游离脂肪酸在骨质疏松症和生物材料骨整合中的相互作用正在研究中。完成间充质干细胞的成骨和成脂分化在脂肪因子和骨保护药物方面的详细分析。此外，内脏素对生物材料界面上的成脂细胞和成骨细胞分化的影响也在研究中。在骨质疏松症动物模型中，将评估visfatin改变的效果。通过质谱成像，我们将分析与生物材料和脂肪因子接触后细胞膜和骨骼本身的脂质组成。

In B11, the interaction of adipokines and free fatty acids concerning osteoporosis and osseointegration of biomaterials is under investigation. The detailed analysis of osteogenic and adipogenic differentiation of mesenchymal stem cells with and without spongiosa transfer with regard to adipokines and osteoprotective drugs shall be completed. Moreover the influence of visfatin to the adiopogenic and osteogenic cell differentiation at the biomaterials interface is under investigation. In an osteoporotic animal model, the effect of visfatin alteration will be evaluated. By using mass spectrometric imaging we will analyse the lipid composition of the cell membrane and in bone itself after contact with biomaterials and adipokines.