Collaborative Research: Bioarchaeology, Osteoimmunology, and Ecoimmunology: Linking Inflammation, Life History Tradeoffs, and Biocultural Change

合作研究：生物考古学、骨免疫学和生态免疫学：将炎症、生活史权衡和生物文化变革联系起来

• 批准号: 2316573
• 负责人: Fabian Crespo
• 金额: $ 12.4万
• 依托单位: University of Louisville Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2316573&HistoricalAwards=false
• 关键词: Collaborative; Research; Bioarchaeology; Osteoimmunology; Ecoimmunology

The immune system and the skeleton are often viewed as separate parts of our biology. However, recent research has revealed that the skeletal and immune systems interact more than previously appreciated as part of the “osteoimmune” system. Hyperinflammation experienced earlier in life, which can result in chronic inflammation, therefore affects the skeleton as well as other parts of the body. This project examines immune and inflammatory proteins in bone that are markers of this complex relationship between bone and immune function and applies them to questions about biocultural processes in human societies. The project advances knowledge in skeletal biology and bioarchaeology by combining traditional observations of skeletal pathology with proteomic analysis to better identify inflammatory responses that may be shaping human morbidity and mortality in the past and present. The broader impacts of the project include student training, including individuals from groups underrepresented in STEM; curriculum expansion; international research collaborations; and engagement with schools, communities, and the public. Early life biological stress and immune system over-activation are thought to produce cascading effects involving phenotypic plasticity and life history trade-offs that shape predilections for later-life inflammatory and hyperinflammatory phenotypes. This project pursues a cross-disciplinary study of skeletal inflammatory diseases, combining observations of periodontal disease and periosteal reaction with proteomic analyses of at least of four independent inflammatory protein biomarkers (osteocalcin, macrophage inflammatory proteins, leukocyte-derived proteins, and neutrophil-derived proteins) in individuals possessing an inferred hyperinflammatory phenotype. The PIs address biocultural hypotheses about the co-occurrence of pathological processes, the role of early life environments in shaping immune response, and the influence of sociocultural dynamics on human biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

免疫系统和骨骼通常被视为我们生物学的独立部分。然而，最近的研究表明，作为“骨气免疫”系统的一部分，骨骼和免疫系统的相互作用比以前更大。因此，过度炎症在生命早期经历，可能导致慢性感染，因此会影响骨骼以及身体的其他部位。该项目检查骨骼中的免疫和炎症蛋白是骨骼与免疫功能之间这种复杂关系的标志物，并将其应用于人类社会中生物文化过程的问题。该项目通过将骨骼病理学的传统观察与蛋白质组学分析相结合，以更好地识别可能塑造过去和现在的人类发病率和死亡率的炎症反应，从而提高骨骼生物学和生物考古学的知识。该项目的更广泛影响包括学生培训，包括来自STEM中代表性不足的团体的个人；课程扩展；国际研究合作；并与学校，社区和公众互动。人们认为早期生命生物压力和免疫系统过度激活被认为会产生涉及表型可塑性和生活史的级联效应，这些效果构成了对后期炎症和高炎性表型的预测。该项目对骨骼炎症性疾病进行了跨学科研究，将牙周疾病和骨膜反应的观察结果与至少四种独立的炎性蛋白生物标志物（骨op骨，巨噬细胞，巨噬细胞炎性蛋白质，白细胞增生蛋白质蛋白质和蛋白质蛋白质）的蛋白质组学分析结合在一起表型。 PIS介绍了关于病理过程共同发生的生物文化假设，早期生活环境在塑造免疫反应中的作用以及社会文化动态对人类生物学的影响。该奖项反映了NSF的法定任务，并通过使用基金会的知识优点和广泛影响来评估NSF的法定任务，并被视为诚实的支持。