LEAPS-MPS: Exploring the Utility of Bifunctional Reagents for the Visible Light-Mediated Synthesis of Heterocycles and Biologically Relevant Molecules

LEAPS-MPS：探索双功能试剂在可见光介导的杂环和生物相关分子合成中的实用性

• 批准号: 2316834
• 负责人: John Milligan
• 金额: $ 16.94万
• 依托单位: Thomas Jefferson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2316834&HistoricalAwards=false
• 关键词: LEAPS; MPS; Exploring; Utility; Bifunctional

In this project managed by the Chemistry Division at NSF, Professor Milligan and his students at Thomas Jefferson University aim to design and study new chemical reagents that are capable of forming ring structures in molecules upon exposure to visible light. Prof. Milligan plans to use the newly developed reagents to create new approaches for integrating visible light-enabled chemistry into undergraduate organic chemistry curricula. The project will support and expand partnerships between Thomas Jefferson University and the public school district in the city of Philadelphia. The goals of these efforts are to improve access and understanding of career opportunities in STEM among high school students. Professor Milligan and his students focus on the design, synthesis, and study of reagents that are capable of forming heterocycles upon irradiation with blue LED light. The reagents of interest are “bifunctional” in nature, meaning that they are capable of both traditional polar and visible light-triggered radical reactions sequentially in the same flask. The goal of the work is to leverage the paradigm of chemical reactivity to investigate the synthesis of a variety of cyclic molecules, including molecules of biological interest.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在由NSF化学部管理的该项目中，Milligan教授及其学生托马斯·杰斐逊大学（Thomas Jefferson University）的旨在设计和研究新的化学试剂，这些试剂能够在暴露于可见光的情况下在分子中形成环结构。 Milligan教授计划使用新开发的试剂来创建将可见光的化学反应整合到本科有机化学课程中的新方法。该项目将支持和扩大托马斯·杰斐逊大学和费城公立学区之间的合作伙伴关系。这些努力的目标是提高高中生STEM职业机会的访问和理解。 Milligan教授和他的学生专注于对能够用蓝色LED光照射后能够形成异环的试剂的设计，合成和研究。感兴趣的试剂本质上是“双功能”的，这意味着它们能够依次在同一烧瓶中依次对传统的极性和可见光触发的自由基反应。这项工作的目的是利用化学反应性的范式来研究各种环状分子的综合，包括生物学兴趣的分子。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子和更广泛影响的审查标准来通过评估来通过评估来支持的。