MRI: Track 1 Acquisition of a 400 MHz NMR Spectrometer to Advance Undergraduate Research and Training

该奖项由主要研究仪器和化学研究仪器项目联合支持。里德学院正在购买一台配备宽带探针的400兆赫核磁共振光谱仪，以支持Miriam Bowring教授及其同事Shivani Ahuja和Gonzalo Campillo-Alvarado的研究。该仪器促进了合成化学、生物化学和催化领域的研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。该仪器加强了里德学院化学系各级学生的教育、研究和教学工作，并通过建立的外展项目增加了高中教师和学生的多样化代表。400兆赫核磁共振光谱仪的授予旨在加强各级本科生的研究和教育，特别是在机械有机金属催化、金属离子转运蛋白和分子传感器合成等领域。具体而言，该仪器的研究重点是了解铂甲基配合物和双金属铱钌催化剂合成有机金属化学的新机制。此外，该仪器能够表征细菌atp结合盒转运蛋白的小分子结合物。其他研究还包括利用动态晶体框架表征石化产品的超分子约束，用于传感和分离复杂的化学混合物。为了应对全球氦气供应的挑战，该仪器的收购包括一个具有低损耗低温恒温器的超导磁体，减少了该机构的氦气消耗。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Reed College is acquiring a 400 MHz NMR spectrometer equipped with a broadband probe to support the research of Professor Miriam Bowring along with colleagues Shivani Ahuja and Gonzalo Campillo-Alvarado. This instrument facilitates research in the areas of synthetic chemistry, biochemistry, and catalysis. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students at all levels in the Chemistry Department at Reed College and enables increased diverse representation of high school teachers and students through established outreach programs.The award of the 400 MHz NMR spectrometer is aimed at enhancing undergraduate research and education at all levels, especially in areas such as mechanistic organometallic catalysis, metal ion transporter proteins, and synthesis of molecular sensors. Specifically, the instrument impacts research focused on understanding new mechanisms in synthetic organometallic chemistry of a platinum methyl complex and a bimetallic iridium-ruthenium catalyst. Additionally, the instrument enables the characterization of small molecule binders of bacterial ATP-binding cassette transporter proteins. Other investigations include characterizing the supramolecular confinement of petrochemicals using dynamic crystalline frameworks for sensing and separating complex chemical mixtures. In response to global helium supply challenges, the acquisition of this instrument includes a superconducting magnet with a low loss cryostat reducing the institution’s consumption of helium.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.