MRI: Track 1 Acquisition of NMR Instrument for Research and Undergraduate Research Training

MRI：第 1 轨道采购 NMR 仪器用于研究和本科生研究培训

• 批准号: 2320384
• 负责人: Edward Fenlon
• 金额: $ 39.07万
• 依托单位: Franklin and Marshall College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320384&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; NMR; Instrument

This award is jointly supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation (CRIF) programs. Franklin and Marshall College is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer equipped with a broadband probe to support the research of Professor Edward Fenlon along with colleagues Sarah Tasker, and Davide Lionetti. This instrument facilitates research in the areas of physical organic chemistry, structural biology, and materials science. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. Using the intrinsic magnetic properties of atomic nuclei, it is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students, including undergraduates from underrepresented groups, at all levels in the Chemistry Department as well as provides accessibility for use at a nearby community college, Harrisburg Area Community College.The award of the 400 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic and mechanistic organic, biophysics, and biochemistry. Specifically, the instrument enables research focusing on the development of new radicals for dynamic nuclear polarization measurements and studying vibrational coupling to measure internuclear distances in DNA, RNA, and proteins. Other investigations include developing the reactivity of s-aryl thioformate reagents and the synthesis and biological evaluation of antibacterial natural products and their derivatives. Additional research projects to be enabled by the 400 MHz NMR spectrometer include facilitating multielectron reactivity with bidentate ligands, enabling cooperative reactivity in multimetallic complexes, and tailoring nanoparticles via post-synthetic transformations. In response to global helium supply challenges, the acquisition of this instrument includes a superconducting magnet with a low loss cryostat reducing the institution’s consumption of helium.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器（MRI）和化学研究仪器（CRIF）项目共同支持。富兰克林和马歇尔学院正在购买一台配备宽带探针的400兆赫核磁共振（NMR）光谱仪，以支持爱德华·芬伦教授及其同事萨拉·塔斯克和戴维·利奥内蒂的研究。该仪器促进了物理有机化学、结构生物学和材料科学领域的研究。总的来说，核磁共振波谱学是化学家用来阐明分子结构的最有力的工具之一。利用原子核的固有磁性，它被用来识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。该仪器加强了学生的教育、研究和教学工作，包括来自未被充分代表的群体的本科生，在化学系的所有级别，并为附近的社区学院哈里斯堡地区社区学院提供了可访问性。授予400兆赫核磁共振光谱仪的目的是加强各级的研究和教育，特别是在合成和机械有机、生物物理学和生物化学等领域。具体来说，该仪器使研究重点集中于新自由基的发展，用于动态核极化测量和研究振动耦合，以测量DNA， RNA和蛋白质的核间距。其他研究包括开发s-芳基硫代甲酸试剂的反应性以及抗菌天然产物及其衍生物的合成和生物学评价。400 MHz核磁共振光谱仪将支持的其他研究项目包括促进双齿配体的多电子反应性，促进多金属配合物的协同反应性，以及通过合成后转化来定制纳米颗粒。为了应对全球氦气供应的挑战，该仪器的收购包括一个具有低损耗低温恒温器的超导磁体，减少了该机构的氦气消耗。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。