MRI: Track 1 Acquisition of NMR Instrument for Research and Undergraduate Research Training

MRI：第 1 轨道采购 NMR 仪器用于研究和本科生研究培训

• 批准号: 2320384
• 负责人: Edward Fenlon
• 金额: $ 39.07万
• 依托单位: Franklin and Marshall College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320384&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; NMR; Instrument

This award is jointly supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation (CRIF) programs. Franklin and Marshall College is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer equipped with a broadband probe to support the research of Professor Edward Fenlon along with colleagues Sarah Tasker, and Davide Lionetti. This instrument facilitates research in the areas of physical organic chemistry, structural biology, and materials science. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. Using the intrinsic magnetic properties of atomic nuclei, it is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students, including undergraduates from underrepresented groups, at all levels in the Chemistry Department as well as provides accessibility for use at a nearby community college, Harrisburg Area Community College.The award of the 400 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic and mechanistic organic, biophysics, and biochemistry. Specifically, the instrument enables research focusing on the development of new radicals for dynamic nuclear polarization measurements and studying vibrational coupling to measure internuclear distances in DNA, RNA, and proteins. Other investigations include developing the reactivity of s-aryl thioformate reagents and the synthesis and biological evaluation of antibacterial natural products and their derivatives. Additional research projects to be enabled by the 400 MHz NMR spectrometer include facilitating multielectron reactivity with bidentate ligands, enabling cooperative reactivity in multimetallic complexes, and tailoring nanoparticles via post-synthetic transformations. In response to global helium supply challenges, the acquisition of this instrument includes a superconducting magnet with a low loss cryostat reducing the institution’s consumption of helium.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究工具（MRI）和化学研究工具（CRIF）计划共同支持。富兰克林和马歇尔学院（Franklin and Marshall College）正在收购配备宽带探测器的400 MHz核磁共振（NMR）光谱仪与同事Sarah Tasker和Davide Lionetti一起支持Edward Fenlon教授的研究。该工具促进了物理组织化学，结构生物学和材料科学领域的研究。通常，NMR光谱是化学家可用的最强大工具之一，用于阐明分子结构。使用原子核的固有磁特性，它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间或固态中分子之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。该工具可以在化学系的各个层面上加强学生的教育，研究和教学工作，包括来自代表性不足的小组的本科生，并为在哈里斯堡地区社区学院提供可访问性。授予400 MHz NMR光谱仪的奖励，旨在在各个级别上加强研究和教育。特别是，该仪器能够研究针对动态核极化测量和研究振动偶联的新自由基的研究，以测量DNA，RNA和蛋白质中的核能距离。其他研究包括开发S-芳基硫代酯试剂的反应性以及抗菌天然产物及其衍生物的合成和生物学评估。 400 MHz NMR光谱仪将启用其他研究项目，包括支持与鸟类配体的多电体反应性，在多层金属络合物中启用合作反应性，以及通过合成后变换来调整纳米颗粒。为了应对全球氦气供应挑战，该工具的收购包括一个超导磁铁，低损失低温恒温器减少了该机构对氦气的消费。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的影响审查标准来通过评估来通过评估来获得的支持。