MRI: Track 1 Acquisition of NMR Instrument for Research and Undergraduate Research Training

该奖项由主要研究仪器(MRI)和化学研究仪器(CRIF)计划联合支持。富兰克林和马歇尔学院正在购买一台配备宽带探头的400 MHz核磁共振(核磁共振)光谱仪，以支持爱德华·芬隆教授及其同事萨拉·塔斯克和戴维德·莱内蒂的研究。该仪器促进了物理有机化学、结构生物学和材料科学领域的研究。总体而言，核磁共振波谱是化学家用于阐明分子结构的最强大的工具之一。利用原子核的固有磁性，它被用来识别未知物质，表征分子内原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这台仪器加强了化学系各级学生的教育、研究和教学努力，包括来自代表性不足群体的本科生，并提供了在附近的社区学院哈里斯堡地区社区学院使用的机会。授予400 MHz核磁共振光谱仪的目的是加强所有级别的研究和教育，特别是在合成和机械有机、生物物理和生物化学等领域。具体地说，该仪器使研究能够专注于开发用于动态核极化测量的新自由基，并研究振动耦合以测量DNA、RNA和蛋白质中的核间距离。其他研究包括开发S-芳基硫代甲酸酯试剂的反应性，以及抗菌天然产物及其衍生物的合成和生物学评价。由400 MHz核磁共振波谱仪实现的其他研究项目包括促进与双齿配体的多电子反应，实现多金属络合物中的合作反应，以及通过合成后转化来定制纳米颗粒。作为对全球氦供应挑战的回应，这台仪器的收购包括一个具有低损耗低温恒温器的超导磁体，减少了机构的氦消耗。这项奖励反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation (CRIF) programs. Franklin and Marshall College is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer equipped with a broadband probe to support the research of Professor Edward Fenlon along with colleagues Sarah Tasker, and Davide Lionetti. This instrument facilitates research in the areas of physical organic chemistry, structural biology, and materials science. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. Using the intrinsic magnetic properties of atomic nuclei, it is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students, including undergraduates from underrepresented groups, at all levels in the Chemistry Department as well as provides accessibility for use at a nearby community college, Harrisburg Area Community College.The award of the 400 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as synthetic and mechanistic organic, biophysics, and biochemistry. Specifically, the instrument enables research focusing on the development of new radicals for dynamic nuclear polarization measurements and studying vibrational coupling to measure internuclear distances in DNA, RNA, and proteins. Other investigations include developing the reactivity of s-aryl thioformate reagents and the synthesis and biological evaluation of antibacterial natural products and their derivatives. Additional research projects to be enabled by the 400 MHz NMR spectrometer include facilitating multielectron reactivity with bidentate ligands, enabling cooperative reactivity in multimetallic complexes, and tailoring nanoparticles via post-synthetic transformations. In response to global helium supply challenges, the acquisition of this instrument includes a superconducting magnet with a low loss cryostat reducing the institution’s consumption of helium.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.