MRI: Track 1: Acquisition of a Liquid Chromatography-High Resolution Mass Spectrometry System for Multidisciplinary Research and Training

MRI：轨道 1：获取用于多学科研究和培训的液相色谱-高分辨率质谱系统

• 批准号: 2320410
• 负责人: Xinzhu Pu
• 金额: $ 71万
• 依托单位: Boise State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320410&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Liquid; Chromatography

This award is funded by the Major Research Instrumentation Program and the Chemistry Research Instrumentation Program. Boise State University is acquiring a high-resolution accurate-mass ultra-high pressure liquid chromatography - mass spectrometry (LC-MS) system. The new LC-MS system will vastly improve research infrastructure at Boise State University to support investigators finding solutions to their research questions and increase their productivity. This system will also provide training to graduate, undergraduate, and high school students in modern mass spectrometry techniques as future scientists. The new mass spectrometry system will benefit a broad scientific research community and have a significant impact on the research infrastructure and local economy in the State of Idaho. It will foster collaborative investigations with 12 other colleges, universities and research foundations in the State of Idaho, as well as with local industrial partners.The acquisition of the high-resolution LC-MS system will enable new capabilities in proteomics and metabolomics research at Boise State University in model and non-model organisms, discovery of novel proteins and metabolites from non-model plants, microbes, and animals, and monitor biomarkers of stress in cells, organisms, habitats, and social-ecological systems. The high-resolution, accurate-mass data will be used to address challenges for the comprehensive characterization of complex proteomes and metabolomes for a large number of current and future research projects at Boise State University. These research projects include integrating genomics, proteomics, and metabolomics to predict plant tolerance in wild vertebrate herbivores, investigating impact of smoke on potato growth, storage and profitability, lipidomic and proteomic profiling of autophagosome membrane, understanding the role of MTA/SAH nucleosidase deficiency in bacteria and protozoan parasites, elucidating function of tyrosine sulfation in extracellular fibrillogenesis, and carbon capture from hot springs capnophiles microbial mats. Graduate students in Biology, Chemistry, Biomolecular Sciences, Ecology, Evolution & Behavioral Biology, and Material Science will benefit from the research enabled by the acquisition of the high-resolution LC-MS.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由重大研究仪器计划和化学研究仪器计划资助。博伊西州立大学正在获得一种高分辨率、准确质量的超高压液质联用(LC-MS)系统。新的LC-MS系统将极大地改善博伊西州立大学的研究基础设施，以支持研究人员为他们的研究问题找到解决方案，并提高他们的生产率。该系统还将为研究生、本科生和高中生提供现代质谱学技术方面的培训，作为未来的科学家。新的质谱学系统将使广泛的科学研究社区受益，并对爱达荷州的研究基础设施和当地经济产生重大影响。它将促进与爱达荷州其他12所学院、大学和研究基金会以及当地工业合作伙伴的合作研究。收购高分辨率LC-MS系统将使博伊西州立大学在模式生物和非模式生物的蛋白质组学和代谢组学研究方面具有新的能力，从非模式植物、微生物和动物中发现新的蛋白质和代谢物，并监测细胞、生物体、栖息地和社会生态系统中的应激生物标志物。这些高分辨率、准确的海量数据将用于应对博伊西州立大学当前和未来大量研究项目中复杂蛋白质组和代谢组的综合表征所面临的挑战。这些研究项目包括整合基因组学、蛋白质组学和代谢组学以预测野生脊椎动物草食动物的植物耐受性、调查烟雾对马铃薯生长、储存和盈利的影响、自噬体膜的脂质学和蛋白质组学分析、了解MTA/SAH核苷酶缺乏在细菌和原生动物寄生虫中的作用、阐明酪氨酸硫化在细胞外纤维蛋白形成中的作用以及从温泉嗜毛虫微生物垫子中捕获碳的作用。生物学、化学、生物分子科学、生态学、进化与行为生物学以及材料科学的研究生将从获得高分辨率LC-MS的研究中受益。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。