MRI: Track 1: Acquisition of a Liquid Chromatography-High Resolution Mass Spectrometry System for Multidisciplinary Research and Training

该奖项由主要研究仪器计划和化学研究仪器计划资助。博伊西州立大学正在购买一种高分辨率精确质量超高压液相色谱-质谱（LC-MS）系统。新的LC-MS系统将大大改善博伊西州立大学的研究基础设施，以支持研究人员找到解决他们的研究问题的方法，并提高他们的生产力。该系统还将为研究生、本科生和高中生提供现代质谱技术方面的培训，使他们成为未来的科学家。新的质谱系统将使广大的科研界受益，并对爱达荷州的研究基础设施和当地经济产生重大影响。它将促进与爱达荷州的其他12所学院、大学和研究基金会以及当地工业合作伙伴的合作研究。高分辨率LC-MS系统的收购将使博伊西州立大学在模型和非模型生物体的蛋白质组学和代谢组学研究方面具有新的能力，从非模型植物、微生物和动物中发现新的蛋白质和代谢物，并监测细胞、生物体、栖息地和社会生态系统中的压力生物标志物。高分辨率，准确的质量数据将用于解决复杂的蛋白质组和代谢组的大量当前和未来的研究项目在博伊西州立大学的全面表征的挑战。这些研究项目包括整合基因组学，蛋白质组学和代谢组学以预测野生脊椎动物食草动物的植物耐受性，调查烟雾对马铃薯生长，储存和盈利能力的影响，自噬体膜的脂质组学和蛋白质组学分析，了解MTA/SAH核苷酶缺乏在细菌和原生动物寄生虫中的作用，阐明酪氨酸硫酸化在细胞外纤维形成中的功能，以及从温泉嗜二氧化碳微生物垫中捕获碳。生物学，化学，生物分子科学，生态学，进化行为生物学和材料科学的研究生将受益于高分辨率LC-MS的收购所实现的研究。该奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

This award is funded by the Major Research Instrumentation Program and the Chemistry Research Instrumentation Program. Boise State University is acquiring a high-resolution accurate-mass ultra-high pressure liquid chromatography - mass spectrometry (LC-MS) system. The new LC-MS system will vastly improve research infrastructure at Boise State University to support investigators finding solutions to their research questions and increase their productivity. This system will also provide training to graduate, undergraduate, and high school students in modern mass spectrometry techniques as future scientists. The new mass spectrometry system will benefit a broad scientific research community and have a significant impact on the research infrastructure and local economy in the State of Idaho. It will foster collaborative investigations with 12 other colleges, universities and research foundations in the State of Idaho, as well as with local industrial partners.The acquisition of the high-resolution LC-MS system will enable new capabilities in proteomics and metabolomics research at Boise State University in model and non-model organisms, discovery of novel proteins and metabolites from non-model plants, microbes, and animals, and monitor biomarkers of stress in cells, organisms, habitats, and social-ecological systems. The high-resolution, accurate-mass data will be used to address challenges for the comprehensive characterization of complex proteomes and metabolomes for a large number of current and future research projects at Boise State University. These research projects include integrating genomics, proteomics, and metabolomics to predict plant tolerance in wild vertebrate herbivores, investigating impact of smoke on potato growth, storage and profitability, lipidomic and proteomic profiling of autophagosome membrane, understanding the role of MTA/SAH nucleosidase deficiency in bacteria and protozoan parasites, elucidating function of tyrosine sulfation in extracellular fibrillogenesis, and carbon capture from hot springs capnophiles microbial mats. Graduate students in Biology, Chemistry, Biomolecular Sciences, Ecology, Evolution & Behavioral Biology, and Material Science will benefit from the research enabled by the acquisition of the high-resolution LC-MS.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.