MRI: Track 1: Acquisition of a Gas Chromatography-Mass Spectrometer for Advancing Research and Education at Montclair State University

MRI：轨道 1：采购气相色谱-质谱仪以推进蒙特克莱尔州立大学的研究和教育

• 批准号: 2320458
• 负责人: Jaclyn Catalano
• 金额: $ 17.21万
• 依托单位: Montclair State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320458&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Gas; Chromatography

This award is funded by the Major Research Instrumentation Program and the Chemistry Research Instrumentation Program. Montclair State University is acquiring a Gas Chromatography-Mass Spectrometer with a pyrolysis unit (Py-GC/MS) to support Professor Jaclyn Catalano and colleagues Nathanael Hirscher, Nina Goodey, Jinshan Gao, Meiyin Wu, and 11 additional faculty members in three departments across the university. This instrument allows for routine separation of liquid and solid samples with high sensitivity and detection of mass to charge ratios. This versatile instrumental setup allows for different sample types encompassing the broad research and teaching needs of the College of Science and Mathematics at Montclair State University. The instrument will be used by the diverse undergraduate and graduate student population performing research. The instrument will be incorporated into coursework pertaining to seven different academic majors and will be used by up to 300 students annually, providing undergraduates with essential research skills for jobs and/or preparing them for professional schools. Programs will be established to include the instrumentation in pre-college student outreach programs.The award is aimed to use the Py-GC/MS instrument to enhance and supplement current ongoing research projects in the fields of biochemistry, analytical, inorganic, and soil chemistry and environmental science. Py-GC/MS is a versatile instrument, capable of analyzing chemical mixtures in the solid (via pyrolysis) or liquid/gas (via standard injection) phase. This allows this instrument to be used by various researchers in different departments on a variety of samples from soils to organic compounds. Multiple research projects will be enhanced by this instrument, including (1) discovery and development of more specific non toxic drugs to be activated (made toxic) by a specific enzyme; (2) evaluation of soil remediation strategies by using artificial root exudate solution to initiate degradation of carcinogenic and toxic polycyclic aromatic hydrocarbons. This is especially important because these toxins are environmentally stable, resistant to degradation, and generally persist in the environment for long periods of time; (3) determination of the reaction intermediates for the synthesis of glycan standards and free radical tags, which will benefit the development of novel free radical tags for glycan quantitation and characterization; (4) synthesizing and testing novel organometallic catalysts for reactions of hydrocarbons and other organic substrates, controlled by tailored organic ligands; (5) assessment of the environmental contaminants in the New York-New Jersey metropolitan area and to investigate human seafood consumption safety. The results will be used to formulate data-driven policy recommendations to safeguard human health. In addition, undergraduates and graduate students will be trained on the instrument as part of their research projects and/or academic coursework.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具计划和化学研究工具计划资助。蒙特克莱州立大学（Montclair State University）正在购买带有热解单元（PY-GC/MS）的气相色谱质量光谱仪，以支持Jaclyn Catalano教授和同事Nathanael Hirscher，Nina Goodey，Nina Goodey，Jinshan Gao，Meiyin Wu，Meiyin Wu以及该大学三个部门的11个其他教师。该仪器允许常规的液体和固体样品分离具有高灵敏度和质量比电荷比的固体样品。这种多功能的工具设置允许不同的样本类型，包括蒙特克莱尔州立大学科学与数学学院的广泛研究和教学需求。该仪器将由多样化的本科和研究生人群进行研究。该乐器将被纳入与七个不同的学术专业有关的课程中，每年将使用多达300名学生使用，从而为大学生提供有关工作的基本研究技能和/或为专业学校做准备。将制定计划将仪器包括在大学前学生外展计划中。该奖项的目的是使用PY-GC/MS工具来增强和补充生物化学，分析，无机和土壤化学和环境科学领域的当前正在进行的研究项目。 PY-GC/MS是一种多功能仪器，能够分析固体（通过热解）或液体/气体（通过标准注射）相中的化学混合物。这允许不同部门的各种研究人员在各种样品中使用该仪器，从土壤到有机化合物。该仪器将增强多个研究项目，包括（1）特定酶发现和开发要激活（有毒）的更具体的非毒性药物； （2）通过使用人工根渗出液来评估土壤修复策略，以启动致癌和有毒多环芳族烃的降解。这尤其重要，因为这些毒素在环境上是稳定的，对退化具有抵抗力，并且长期存在于环境中。 （3）确定反应中间体合成聚糖标准标准和自由基标签的中间体，这将使新型自由基标签的发展用于聚糖定量和表征； （4）合成和测试新型的有机金属催化剂，用于碳氢化合物和其他有机底物的反应，由量身定制的有机配体控制； （5）评估纽约新泽西大都市地区的环境污染物，并调查人类海鲜消费安全性。结果将用于制定数据驱动的政策建议，以保护人类健康。此外，作为其研究项目和/或学术课程的一部分，将在乐器上对本科生和研究生进行培训。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，认为值得通过评估值得支持。