Equipment: MRI: Track 1 Acquisition of a high-performance computer cluster for computational biology

该核磁共振奖将使在北岭加利福尼亚州立大学（CSUN）获得用于计算生物学的高性能计算机集群成为可能。该奖项将支持CSUN计算生物学、生物化学和生物物理学研究的发展和增长，使其能够分析比以前更大的数据集和更复杂的模拟。这项研究的目标是促进我们对各种主题的理解，包括心脏病，免疫系统功能，计算药物设计，医疗植入物，膜蛋白结构和功能，以及微生物在全球变暖中的作用。CSUN的学生中，超过50%来自传统上服务不足的群体，他们将通过专门的研讨会、研究实践经验、计算生物学的新研究型课程以及将集群整合到现有课程中进行培训。此外，pi和高级人员将与当地高中教师在计算/数据科学方面合作，后者将反过来培训当地高中生。该集群具有高内存图形处理单元（gpu）和中央处理单元（cpu）、大内存和存储的平衡，将允许解决目前生命科学中无法解决的问题，并支持计算生物学中当前和新的研究方向。集群的灵活设计将允许pi和高级人员应用计算生物学中使用的广泛方法和方法来表征g蛋白偶联受体（GPCR）信号传导的热力学和结构动力学，创建新方法来预测配体和离子与蛋白质和RNA的结合，开发多尺度框架将蛋白质突变与心律失常联系起来，创建t细胞受体多样性如何影响免疫系统的详细模型。设计和测试防止医疗植入物周围纤维组织生长的处理方法，并使用DNA和RNA序列数据来确定融化的永久冻土中的微生物群落如何对气候变化做出贡献。总的来说，这些项目将进一步了解应用和基础生物技术，并为科学界提供新的软件工具。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This MRI award will enable the acquisition of a high-performance computer cluster for computational biology at California State University, Northridge (CSUN). The award will support the development and growth of research in computational biology, biochemistry, and biophysics at CSUN by enabling the analysis of larger datasets and more complex simulations than previously possible. The goal of this research is to advance our understanding of a diverse range of topics, including heart disease, immune system function, computational drug-design, medical implants, membrane protein structure and function, and the role of microbes in global warming. Students at CSUN, over 50% of whom are from traditionally underserved groups, will be trained through dedicated workshops, hands-on experience in research, a new research-based course in computational biology, and the integration of the cluster into existing courses. Additionally, the PIs and senior personnel will work with local high school teachers in computational/data science, who will, in turn, train local high school students.The cluster, with a balance of high memory graphics processing units (GPUs) and central processing units (CPUs), large-memory, and storage, will allow currently inaccessible problems in life sciences to be addressed and support current as well as new research directions in computational biology. The flexible design of the cluster will allow the PIs and senior personnel to apply the wide range of methods and approaches used in computational biology to characterize the thermodynamics and structural dynamics of G-protein coupled receptor (GPCR) signaling, create new approaches to predict ligand and ion binding to proteins and RNA, develop a multi-scale framework to link protein mutations to cardiac arrhythmias, create detailed models of how T-cell receptor diversity affects immune system, design and test treatments to prevent fibrous tissue growth around medical implants, and use DNA and RNA sequence data to determine how microbial communities in thawing permafrost contribute to climate change. Collectively, these projects will further knowledge in applied and foundational biotechnology and provide new software tools for the scientific community.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.