SBIR Phase I: Real-Time Allergen Detection Technology for Dietary Proteins Transferred to Human Milk

这个小型企业创新研究（SBIR）第一阶段项目的更广泛的影响/商业潜力是提供第一个测试，以准确，快速和经济有效地确定母乳中的过敏原含量。多达25%的婴儿报告对母乳中发现的膳食蛋白质过敏，这通常导致母乳/身体喂养终止。母乳喂养/身体喂养对健康非常有益，继续护理是一个人类健康问题。研究表明，人乳比低过敏性配方奶粉更上级，可提供天然抗体来对抗疾病，降低婴儿猝死综合症的风险，并降低患糖尿病和白血病等疾病的可能性。目前市场上还没有牛奶过敏原的家庭实时检测。这个小型企业创新研究（SBIR）第一阶段项目旨在开发一种实时的家庭过敏原检测测试。该项目为提供第一种机制奠定了基础，以研究早期和经常通过母乳引入过敏原，当免疫系统已被证明对过敏减少策略敏感时。该公司正在申请专利的技术有可能提供一种快速、经济有效地识别过敏原的工具，使父母能够监测可能的过敏原触发因素的存在。该测试由用户在家中设置中实时执行，这与需要将样品发送到实验室进行劳动和资源密集型测定的现有测试相比具有显著优势。侧流技术提供了一个快速和易于阅读的结果，使用户能够快速确定牛奶中是否含有特定的非人类蛋白质片段，这些片段也被认为会引起某些患者的过敏反应。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to provide the first test to determine the allergen content of human milk accurately, quickly, and cost-effectively. As much as 25% of infants have reported allergic responses to dietary proteins found in human milk which often results in breast/body feeding termination. Breast/body feeding is incredibly beneficial to health and continuation of nursing is a human health issue. Studies indicate that human milk is superior to hypoallergenic formula, providing natural antibodies to fight illness, lowering the risk of sudden infant death syndrome, and reducing the probability of developing disorders such as diabetes and leukemia. There is currently no at-home, real-time test for milk allergens on the market.This Small Business Innovation Research (SBIR) Phase I project seeks to develop a real-time at-home allergen detection test. This project lays the groundwork for providing the first mechanism to research early and often allergen introduction through human milk when the immune system has been shown to be susceptible to allergy reduction strategies. The company’s patent-pending technology has the potential to provide a tool to identify allergens quickly and cost-effectively, allowing parents to monitor the presence of likely allergen triggers. The test is performed by the user in a real-time, in an at-home setting, which is a significant advantage over existing tests that require samples to be sent to a laboratory for labor and resource-intensive assays. The lateral flow technology provides a rapid and easy-to-read result, allowing the user to quickly determine whether the milk contains specific non-human protein fragments which are also known to elicit allergic responses in some patients.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.