SBIR Phase I: Enrichment of Cancer DNA for Improved Cancer Diagnostics from Blood

SBIR 第一阶段:富集癌症 DNA 以改善血液癌症诊断

基本信息

  • 批准号:
    2321908
  • 负责人:
  • 金额:
    $ 27.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to improve the diagnosis of residual cancer cells, after treatment of cancer patients. The test will be conducted early and accurately using a simple blood draw. Twenty percent of cancer patients will experience cancer recurrence. Unfortunately, cancer recurrence is not diagnosed until years after initial treatment when the cancer has often metastasized, resulting in poor patient outcomes. As a result, 7% of cancer patients suffer from debilitating fear of cancer recurrence. Early and accurate diagnosing of residual cancer cells will improve the outcome for the 20% of cancer patients who experience recurrence. Additionally, it will help the 7% of cancer patients who suffer from debilitating fear of cancer recurrence. Overall, the costs of treating cancer will be lowered by diagnosing cancer earlier. This Small Business Innovation Research (SBIR) Phase I project seeks to develop a highly accurate diagnostic test for residual cancer from a blood draw. DNA (deoxyribonucleic acid) from cancer cells circulates through the blood stream. This cancer can be detected because of mutations in the DNA of cancer cells. However, cancer DNA is rare compared to normal DNA, which makes diagnosing cancer from a blood draw difficult. Proof-of-concept data has shown that accuracy can be greatly improved through the enrichment of cancer DNA from a sample. After the sample is collected, the DNA goes through rounds of duplication, except a blocker is added to prevent normal DNA from duplicating. Through this process the cancer DNA becomes a larger percentage of the overall DNA in the sample and can be more accurately detected. This project will develop a collection of tests for accurately diagnosing residual colorectal cancer. The key tasks of this project are: 1) demonstrate the clinical robustness of the optimized test method, 2) develop additional tests to cover most colorectal cancers, and 3) demonstrate the sensitivity and specificity of the test methods. This project will lead to earlier and more accurately diagnosed cancer recurrence.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个小企业创新研究(SBIR)第一阶段项目更广泛的影响/商业潜力是改善癌症患者治疗后残留癌细胞的诊断。该测试将使用简单的抽血早期和准确地进行。百分之二十的癌症患者会经历癌症复发。不幸的是,癌症复发直到最初治疗后数年才被诊断出来,此时癌症通常已经转移,导致患者预后不良。因此,7%的癌症患者患有癌症复发的恐惧。早期准确诊断残留癌细胞将改善20%复发癌症患者的预后。 此外,它还将帮助7%的癌症患者,他们因癌症复发而感到虚弱。总体而言,通过早期诊断癌症将降低治疗癌症的成本。这个小型企业创新研究(SBIR)第一阶段项目旨在开发一种高度准确的诊断测试,用于从抽血中检测残留癌症。来自癌细胞的DNA(脱氧核糖核酸)通过血液循环。这种癌症可以被检测到,因为癌细胞的DNA突变。然而,与正常DNA相比,癌症DNA是罕见的,这使得从血液中诊断癌症变得困难。概念验证数据表明,通过从样品中富集癌症DNA可以大大提高准确性。收集样本后,DNA会进行多轮复制,除了加入阻断剂以防止正常DNA复制。通过这个过程,癌症DNA在样本中的总DNA中所占的比例更大,可以更准确地检测到。该项目将开发一系列用于准确诊断残留结直肠癌的测试。该项目的关键任务是:1)证明优化检测方法的临床稳健性,2)开发涵盖大多数结直肠癌的额外检测,3)证明检测方法的灵敏度和特异性。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Matthew Nelson其他文献

High-Output Heart Failure from a Hepatic Hemangioma With Exertion-Induced Hypoxia
  • DOI:
    10.1016/j.amjcard.2015.10.019
  • 发表时间:
    2016-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Aaron A.H. Smith;Matthew Nelson
  • 通讯作者:
    Matthew Nelson
Non-Contact Molecular Chemical Imaging Assessment of Tissue Congestion: A Validation Study Compared to MRI
组织充血的非接触式分子化学成像评估:与 MRI 相比的验证研究
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    A. Saltman;R. Ghosh;P. M. Eckman;Michael Chappuis;Jeremy D Collins;Pamela Morley;Holly Mazis;Robert Schweitzer;M. Enriquez;Shawna K. Tazik;Heather Gomer;Matthew Nelson;P. Treado
  • 通讯作者:
    P. Treado
Hate Crimes in Post-9/11 Pennsylvania
9/11 后宾夕法尼亚州的仇恨犯罪
  • DOI:
    10.1177/2153368715617812
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Matthew Nelson;Alese C. Wooditch;F. Martín;Don Hummer;Shaun L. Gabbidon
  • 通讯作者:
    Shaun L. Gabbidon
Microscale impedance measurements suggest that ionic diffusion is implicated in generating extracellular potentials
  • DOI:
    10.1186/1471-2202-15-s1-p214
  • 发表时间:
    2014-07-21
  • 期刊:
  • 影响因子:
    2.300
  • 作者:
    Claude Bedard;Jean-Marie Gomes;Matthew Nelson;Pierre Pouget;Silvana Valtcheva;Laurent Venance;Yves Gioanni;Thierry Bal;Alain Destexhe
  • 通讯作者:
    Alain Destexhe
How Teachers' Professional Identities Position High-Stakes Test Preparation in Their Classrooms
教师的专业身份如何在课堂上进行高风险的考试准备
  • DOI:
    10.1111/j.1467-9620.2004.00380.x
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Lesley A. Rex;Matthew Nelson
  • 通讯作者:
    Matthew Nelson

Matthew Nelson的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Matthew Nelson', 18)}}的其他基金

MRI: Acquisition of an automated fluorescent microscope and imaging system for undergraduate biology and chemistry research and research training
MRI:采购自动荧光显微镜和成像系统,用于本科生物学和化学研究及研究培训
  • 批准号:
    1919847
  • 财政年份:
    2019
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant
CAREER: Neuropeptidergic and cAMP-mediated regulation of stress-induced sleep in C. elegans
职业:神经肽能和 cAMP 介导的线虫应激诱导睡眠调节
  • 批准号:
    1845020
  • 财政年份:
    2019
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Continuing Grant
STTR Phase I: Carbon capture and high-value isoprene production by fast-growing cyanobacteria
STTR第一阶段:通过快速生长的蓝藻进行碳捕获和高价值异戊二烯生产
  • 批准号:
    1449043
  • 财政年份:
    2015
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant

相似国自然基金

Baryogenesis, Dark Matter and Nanohertz Gravitational Waves from a Dark Supercooled Phase Transition
  • 批准号:
    24ZR1429700
  • 批准年份:
    2024
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
ATLAS实验探测器Phase 2升级
  • 批准号:
    11961141014
  • 批准年份:
    2019
  • 资助金额:
    3350 万元
  • 项目类别:
    国际(地区)合作与交流项目
地幔含水相Phase E的温度压力稳定区域与晶体结构研究
  • 批准号:
    41802035
  • 批准年份:
    2018
  • 资助金额:
    12.0 万元
  • 项目类别:
    青年科学基金项目
基于数字增强干涉的Phase-OTDR高灵敏度定量测量技术研究
  • 批准号:
    61675216
  • 批准年份:
    2016
  • 资助金额:
    60.0 万元
  • 项目类别:
    面上项目
基于Phase-type分布的多状态系统可靠性模型研究
  • 批准号:
    71501183
  • 批准年份:
    2015
  • 资助金额:
    17.4 万元
  • 项目类别:
    青年科学基金项目
纳米(I-Phase+α-Mg)准共晶的临界半固态形成条件及生长机制
  • 批准号:
    51201142
  • 批准年份:
    2012
  • 资助金额:
    25.0 万元
  • 项目类别:
    青年科学基金项目
连续Phase-Type分布数据拟合方法及其应用研究
  • 批准号:
    11101428
  • 批准年份:
    2011
  • 资助金额:
    23.0 万元
  • 项目类别:
    青年科学基金项目
D-Phase准晶体的电子行为各向异性的研究
  • 批准号:
    19374069
  • 批准年份:
    1993
  • 资助金额:
    6.4 万元
  • 项目类别:
    面上项目

相似海外基金

SBIR Phase II: Bioelectrical Cell Enrichment, Sorting, and Recovery with On-Chip Sample Prep and Monitoring
SBIR 第二阶段:通过片上样品制备和监测进行生物电细胞富集、分选和回收
  • 批准号:
    2222933
  • 财政年份:
    2023
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Cooperative Agreement
SBIR Phase I: A novel platform for virus enrichment and isolation
SBIR 第一阶段:病毒富集和分离的新型平台
  • 批准号:
    2222991
  • 财政年份:
    2023
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant
SBIR Phase I: A Microbial Enrichment Device to Reduce the Cost of Sequencing Metagenomes
SBIR 第一阶段:降低宏基因组测序成本的微生物富集设备
  • 批准号:
    1913372
  • 财政年份:
    2019
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant
SBIR Phase II: Low-cost Detection and Enrichment of Nucleic Acids by Interfacing with Commercially Available Cell Sorters
SBIR 第二阶段:通过与市售细胞分选仪连接来低成本检测和富集核酸
  • 批准号:
    1556119
  • 财政年份:
    2016
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant
SBIR Phase I: Low-cost Detection and Enrichment of Nucleic Acids by Interfacing with Commercially Available Cell Sorters
SBIR 第一阶段:通过与市售细胞分选仪连接来低成本检测和富集核酸
  • 批准号:
    1447889
  • 财政年份:
    2015
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant
SBIR Phase I: Resonant Acoustic Cell Enrichment (RACE) Technique for Rare Cell Detection in Blood
SBIR 第一阶段:用于血液中稀有细胞检测的共振声学细胞富集 (RACE) 技术
  • 批准号:
    1113300
  • 财政年份:
    2011
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant
SBIR Phase II: Modular Oxygen Enrichment Device to Improve Combustion Efficiency
SBIR第二阶段:模块化富氧装置提高燃烧效率
  • 批准号:
    0548714
  • 财政年份:
    2006
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant
SBIR Phase II: Quantitative Detection of Bacterial Pathogens in Seeds by Use of a Novel Enrichment Technique Coupled with Automated Real-Time PCR
SBIR 第二阶段:利用新型富集技术结合自动实时 PCR 定量检测种子中的细菌病原体
  • 批准号:
    0450649
  • 财政年份:
    2005
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant
SBIR Phase I: Continuous Adsorption Technology for Oxygen Enrichment
SBIR第一期:连续吸附富氧技术
  • 批准号:
    0419821
  • 财政年份:
    2004
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant
SBIR Phase I: Quantitative Detection of Bacterial Pathogens in Seeds by Use of a Novel Enrichment Technique Coupled with Automated Real-Time PCR
SBIR 第一阶段:利用新型富集技术结合自动实时 PCR 定量检测种子中的细菌病原体
  • 批准号:
    0320498
  • 财政年份:
    2003
  • 资助金额:
    $ 27.5万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了