I-Corps: Flow regulated nasal oxygen delivery device

该I-Corps项目更广泛的影响/商业潜力是开发一种医疗器械，用于监测通过鼻插管接受氧气治疗的患者的通气，并根据监测仪的测量结果自动调整呼吸机设置。目前，许多医院中的鼻插管患者由于与用正压通气治疗的患者相比相对不严重而很少被检查，并且目前的插管装置无法监测患者通气。总的来说，由于缺乏早期预警系统或任何可量化的患者数据，这导致了由于人员短缺而导致的延迟护理和恶化的结果。设计用于监测插管患者的氧气需求并自主对患者氧气需求的增加/减少做出反应的设备可以改善医院的结果，并使医院能够在呼吸治疗师人手短缺的情况下改善患者的结果。该I-Corps项目基于一种方法的开发，该方法用于基于呼吸期间在鼻子内进行的压力测量来无创地估计通过患者鼻通道的空气流量。使用能够在操作期间进行这些测量的专门设计的插管，该方法可以用于估计在氧疗期间由患者吸入的空气的体积。 成功地估计这些体积需要仔细的数据处理和关于人体鼻腔通道中气压和流量之间关系的详细信息。一个原型装置被示出测量人体模型中的空气吸入体积，其精度为毫升量级，准确度为5%量级。 这些结果表明，所提出的技术可以实施到一个商业医疗设备，能够监测和反应的变化，呼吸状态的病人接受氧气治疗，通过nasal canning.This奖项反映了NSF的法定使命，并已被认为是值得支持的评估使用基金会的智力价值和更广泛的影响审查标准。

The broader impact/commercial potential of this I-Corps project is the development of a medical device for monitoring the ventilation of patients receiving oxygen therapy by nasal cannula, and for autonomously adjusting ventilator settings based on the measurements of the monitor. Currently, nasal cannula patients in many hospitals are checked infrequently due to their relative non-severity compared to patients treated with positive pressure ventilation, and current cannula devices have no way to monitor patient ventilation. Taken together, this leads to delayed care due to staffing shortages and worsening outcomes due to the lack of an early warning system or any quantifiable patient data. A device that is designed to monitor the oxygen demands of cannula patients and autonomously react to increases/decreases in patient oxygen demands may improve outcomes in hospitals and enable hospitals to improve patient outcomes in the face of respiratory therapist staffing shortages. This I-Corps project is based on the development of a method for noninvasively estimating the flowrate of air through a patient’s nasal passage based on pressure measurements taken inside the nose during respiration. Using a specially designed cannula capable of taking these measurements during operation, the method may be used to estimate the volumes of air inspired by the patient during oxygen therapy. Successful estimation of these volumes requires careful data processing and detailed information about the relationship between air pressure and flow in the human nasal passage. A prototype device was shown to measure the inspired volumes of air in a mannequin with precision in the order of milliliters and accuracy in the order of 5%. These results indicate that the proposed technology may be implemented into a commercial medical device capable of monitoring and reacting to changes in the respiratory status of patients receiving oxygen therapy via nasal cannula.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.