SBIR Phase I: Sprayable hydrogel sealant for gastrointestinal wound protection

这项小企业创新研究（SBIR）第一阶段项目的更广泛影响/商业潜力集中在改进微创手术中的伤口闭合方法，如内窥镜检查和机器人手术。通过利用基于生物相容性、可生物降解聚合物的创新水凝胶技术，该项目旨在建立外科伤口和穿孔的弹性屏障。这种革命性的方法，没有繁琐的金属夹，有望避免延迟出血，穿孔，感染和术后并发症。该技术最初是为胃肠道设计的，但满足了临床未满足的需求，并扩展到心血管和肺部的密封应用。社会影响在改善患者预后和降低医疗成本方面是显而易见的，而商业潜力包括广泛采用优越的伤口闭合解决方案。这个小企业创新研究（SBIR）第一阶段项目的重点是开发一种多功能，可喷涂的密封剂套件，为胃肠道伤口提供长期保护。该技术采用多种粘附机制，确保生物表面的持续粘附。它通过导管输送，与商业内窥镜和微创设备无缝集成，优化手术工作流程。该项目的目标包括改进粘合剂配方以满足胃肠道要求和严格的对比测试。预期的技术成果包括提高手术效率，降低并发症发生率，改善伤口愈合，将这项创新定位为微创手术的变革力量。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project centers on improving wound closure methods in minimally invasive procedures, such as endoscopy and robotic surgery. By harnessing innovative hydrogel technology based on biocompatible, biodegradable polymers, this project aims to establish a resilient barrier over surgical wounds and perforations. This transformative approach, devoid of cumbersome metal clips, promises to avert delayed bleeding, perforations, infections, and post-procedural complications. Initially designed for the gastrointestinal tract, the technology caters to unmet clinical needs, extending to applications in cardiovascular and lung sealing. The societal impact is evident in improved patient outcomes and reduced healthcare costs, while the commercial potential includes widespread adoption of a superior wound closure solution.This Small Business Innovation Research (SBIR) Phase I project focuses on the development of a versatile, sprayable sealant kit that delivers prolonged protection for gastrointestinal wounds. Employing multiple adhesion mechanisms, the technology ensures sustained adhesion across biological surfaces. Delivered via a catheter, it seamlessly integrates with commercial endoscopes and minimally invasive devices, optimizing surgical workflow. The project objectives involve the refinement of the adhesive formulation to meet gastrointestinal requirements and rigorous comparative testing. Anticipated technical outcomes encompass enhanced procedure efficiency, reduced complication rates, and improved wound healing, positioning this innovation as a transformative force in minimally invasive surgery.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.