Conference: 2024 Thiol-Based Redox Regulation and Signaling GRC and GRS: Mechanisms and Consequences of Redox Signaling

该奖项支持将于2024年7月13日至19日在西班牙卡斯特尔德费尔斯的Rey Don Jaime Grand酒店举行的第九届两年一度的戈登研究会议(GRC)和相关的戈登研究研讨会(GRS)，主题是基于硫醇的氧化还原调节和信号。GRC/GRS汇集了由化学生物学家、生物化学家、细胞生物学家和生理学家组成的不同的国际社区，举行了为期数天的密集会议，介绍和讨论该领域的最新研究，勾勒出该工作的未来方向，并建立合作关系，以完成这一未来的研究。聚焦、亲密的会议形式将为与会者提供充分的机会，进行深入的研究讨论，并促进网络联系。该奖项的资金严格用于支付美国研究生和博士后实习生的注册费用，以方便不同群体的参与者参加他们职业生涯的早期阶段。GRS为初级科学家提供了一个独特的职业发展机会。会议经验的这一GRC前部分由研究生和博士后研究员组织，并为他们组织，使会议规划经验和规划侧重于将初级科学家纳入氧化还原信号社区，促进下一代科学家的参与和指导，并确保这一研究领域的持续活力。GRC与会者遵守严格的非正式政策，鼓励公开交流和合作，创造独特的智力体验。2024年GRC的主题是基于硫醇的氧化还原信号机制，重点是控制生死决定的细胞内和细胞间信号的空间和时间方面。主要会议主题包括氧化还原生物学的工具和技术，低分子硫醇信号和翻译后修饰，蛋白质生物发生和周转的氧化还原控制，活性硫物种和蛋白质氧化还原开关，脂质氧化和氧化还原依赖的细胞死亡，细胞器和细胞间的氧化还原串扰，宿主-病原体和免疫反应，以及代谢和年龄相关病理学中的氧化还原信号。GRC/GRS将通过大力鼓励不同的初级科学家群体(研究生、博士后研究员和新任命的教师)积极参与会议的各个方面，将研究、教育、培训和职业发展整合在一起。除了正式的演讲外，会议还包括指定的时间，供职业生涯各个阶段的个人进行海报展示。上午GRC全体会议期间的海报预览，GRS期间的职业发展小组，以及GRC期间的PowerHour活动，将进一步支持我们社会所有成员的专业成长。会议的成功将使用GRC既定的指导方针进行评估。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award supports the 9th biennial Gordon Research Conference (GRC) and the associated Gordon Research Seminar (GRS) on Thiol-Based Redox Regulation and Signaling to be held July 13-19, 2024, at the Rey Don Jaime Grand Hotel in Castelldefels, Spain. This GRC/GRS brings together a diverse international community of chemical biologists, biochemists, cell biologists, and physiologists for a multi-day intensive meeting to present and discuss the latest research in the field, outline the future directions of that work, and establish collaborative relationships to accomplish this future research. The focused, intimate conference format will offer ample opportunities for attendees to engage in in-depth research discussions and facilitate networking. Funds from this award are strictly applied to defray registration costs for U.S.-based graduate students and postdoctoral trainees, to facilitate attendance of a diverse groups of participants from early stages of their careers. A unique professional development opportunity for junior scientists is provided by the GRS. This pre-GRC component of the Conference experience is organized by and for graduate students and postdoctoral fellows, enabling conference planning experience and programming focused on integrating junior scientists into the redox signaling community, promoting the engagement and mentoring of the next generation of scientists, and ensuring the continued vitality of this research field. GRC attendees abide by a strict off-the-record policy to encourage open communication and collaboration, creating a distinctive intellectual experience.The theme of the 2024 GRC is the mechanisms of thiol-based redox signaling, with an emphasis on the spatial and temporal aspects of signaling within and between cells that control life and death decisions. Major meeting topics include tools and technologies for redox biology, signaling via low molecular weight thiols and post-translational modifications, redox control of protein biogenesis and turnover, reactive sulfur species and protein-redox switches, lipid oxidation and redox-dependent cell death, inter-organelle and inter-cellular redox crosstalk, host-pathogen and immune responses, and redox-signaling in metabolism and age-associated pathologies. This GRC/GRS will integrate research, education, training, and career development by strongly encouraging the active participation of a diverse group of junior scientists (graduate students, postdoctoral fellows, and newly appointed faculty) in all aspects of the conference. In addition to formal talks, the conferences include designated time for poster sessions from individuals of all career stages. Poster previews during the morning plenary GRC sessions, a career development panel during the GRS, and a PowerHour event during the GRC, will further support the professional growth of all members of our community. The success of the meeting will be assessed using established GRC guidelines.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.