Conference: 2024 Post-Transcriptional Gene Regulation Gordon Research Conference and Seminar: The Versatility of RNA in the Living World

该奖项将为题为“RNA在生活世界中的多功能性”的2024年转录后基因调控戈登研究会议(GRC)及其相关的戈登研究研讨会(GRS)“基因调控中的RNA及其治疗潜力”提供支持。GRS(7月13日至14日)将为博士后和研究生提供一个论坛，介绍他们的工作并讨论该领域的新想法，其中将包括一个职业指导小组。GRS的目标是通过创造一个大学、包容和以学员为重点的环境，促进与会者的科学和职业发展，为促进RNA生物学的科学发现做出贡献。为期五天的GRC计划(7月14日至19日)将包括来自RNA生物学的实习生、早期和高级科学家的演讲，他们都处于转录后基因调控领域的前沿。此外，GRC将包括一个Power Hour，专门解决与增加STEM领域广泛和多样化人才的参与和留住有关的问题。GRC和GRS的出席人数上限分别为200人和70人。如此小的会议规模将有助于确保与会者之间有足够的机会进行公开讨论和有意义的互动，推动对转录后基因调控的新见解。所有生物都通过转录后基因调控对环境做出反应，并维持正常的细胞行为。通过RNA剪接、3‘端形成、RNA稳定性等在转录后调控基因表达，细胞建立任何给定环境所需的适当基因表达模式。因此，了解RNA生物学中的这些机制对于确定正常和疾病状态都是至关重要的，并将在开发治疗方法方面发挥重要作用。例如，最近开发的COVID19mRNA疫苗的历史例证了驱动转录后基因调控的基本RNA生物学如何广泛地影响人类状况。深入了解转录后基因调控是发展信使核糖核酸疫苗的必要条件。转录后基因调控GRC和GRS的科学计划解决了该领域的前沿话题，包括RNA修饰和结构、RNA与疾病和非编码RNA等。重要的是，将在GRC/GRS上展示的科学预计将是未发表的工作，因此会议将激发对新想法和新出现的问题的讨论，从而促进该领域的科学进步。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award will provide support for the 2024 Gordon Research Conference (GRC) on Post-Transcriptional Gene Regulation titled “The Versatility of RNA in the Living World” as well as its associated Gordon Research Seminar (GRS), “RNA in Gene Regulation and Its Therapeutic Potential”. The GRS (July 13-14) will provide a forum for postdocs and graduate students to present their work and discuss new ideas in the field, and it will include a career mentorship panel. The goal of the GRS is to contribute to the advancement of scientific discovery in RNA biology by creating a collegial, inclusive, and trainee-focused environment to facilitate both scientific and career development of attendees. The five-day GRC program (July 14-19) will include talks from trainees, early stage, and senior scientists in RNA biology, all of whom are at the cutting-edge of the post-transcriptional gene regulation field. In addition, the GRC will include a Power Hour that specifically addresses issues related to increasing participation and retention of broad and diverse talent in STEM fields. Attendance at the GRC and GRS will be capped at 200 and 70 attendees, respectively. This small conference size will help to ensure that there is ample opportunity for open discussion and meaningful interactions among the participants that propel new insights into post-transcriptional gene regulation. All organisms respond to their environment and maintain normal cell behavior through post-transcriptional gene regulation. By regulating gene expression post-transcriptionally through RNA splicing, 3´ end formation, RNA stability, etc., cells establish the proper gene expression patterns required for any given environment. Thus, an understanding of these mechanisms in RNA biology is essential to define both normal and disease states and will be important in developing therapies. For example, the recent history of COVID19 mRNA vaccine development exemplifies how the fundamental RNA biology that drives posttranscriptional gene regulation can broadly impact the human condition. An in-depth understanding of posttranscriptional gene regulation was required for the development of mRNA vaccines. The scientific programs at the Post-Transcriptional Gene Regulation GRC and GRS address cutting-edge topics in the field, including RNA modifications and structure, RNA and disease, and noncoding RNA, among others. Importantly, the science that will be presented at the GRC/GRS is expected to be unpublished work, so that the conferences stimulate discussions on novel ideas and emerging questions, and thus catalyze scientific advances in the field.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.