Biocompatibility and tissue integration of an innovative laser-nanostructured titanium surface - transfer of an air-and space technology

创新激光纳米结构钛表面的生物相容性和组织整合——航空航天技术的转移

• 批准号: 259169326
• 负责人: Privatdozent Dr. Max Daniel Kauther
• 金额: --
• 依托单位: Zentrales Tierlaboratorium
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/259169326?language=en
• 关键词: Biocompatibility; tissue; integration; innovative; laser

The focus of our research project is to examine an innovative air and space technology of a laser-nanostructured surface morphology, which will be transferred to arthroplasty.In cell culture and in animal experiments the biocompatibility and the ingrowth of this new surface will be tested and compared to conventional surface treatments of arthroplasty. In the cell culture the interaction of osteoblasts with various conventional and laser-nanostructured titanium surfaces (plasma spray, and titanium-niobium-nitrite) will be analyzed using various biomarkers for biomineralization.In the rabbit experiment titanium implants (each coated with a titanium plasma spray, or with titanium-niobium-nitrite and treated with laser or untreated) will be introduced into the distal femur. The initial stability is examined in push out tests using fresh rabbit femora. Further push out tests will be performed after 28 and 56 days to show the quality of osteointegration. Bone apposition to the implant will be examined histologically and by electron microscopy and X-ray scans.

我们的研究项目的重点是研究一种创新的激光纳米结构表面形貌的空气和空间技术，该技术将转移到关节成形术中。在细胞培养和动物实验中，将测试这种新表面的生物相容性和长入性，并与传统的关节置换术表面处理进行比较。在细胞培养中，将使用各种生物矿化标志物分析成骨细胞与各种常规和激光纳米结构钛表面（等离子喷雾和钛铌亚硝酸盐）的相互作用。在兔实验中，将钛植入物（每个植入物都涂有钛等离子喷雾，或涂有钛-铌-亚硝酸盐，并经激光处理或未经处理）引入股骨远端。用新鲜的兔股骨进行推出试验，检验其初始稳定性。28和56天后将进行进一步的推出测试，以显示骨整合的质量。将通过组织学、电子显微镜和x射线扫描检查骨与种植体的相对位置。