Understand and reshape the impact of “aged” adaptive immunity and type 2 diabetes/obesity on fracture healing

了解并重塑“老年”适应性免疫和 2 型糖尿病/肥胖对骨折愈合的影响

• 批准号: 259474383
• 负责人: Privatdozentin Dr. Katharina Schmidt-Bleek
• 金额: --
• 依托单位: Julius Wolff Institut für Biomechanik und Muskuloskeletale Regeneration (CVK)
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/259474383?language=en
• 关键词: Understand; reshape; impact; aged; adaptive

Immune cells are essential for the onset of regeneration and for the successful completion of the process. A balanced adaptive immune response is a deciding factor in the regenerative cascade and immune modulatory strategies represent a new therapeutic approach to enhance healing. Even though the osteo-immunological research has progressed remarkably, the adaptive immunity is often not considered. Here, we will study the influence of the adaptive immunity in regenerative processes of elderly compromised patients (obese/ diabetic), develop a strategy to distract unfavourable immune cells from partaking in the early inflammatory reaction of healing, and analyse the influence of T cells on the collagen 1 deposition and osteogenic progenitor cell distribution during callus formation in bone healing situations. In close cooperation with other projects of the Research Unit the influence of adaptive immune cells on cellular senescence, adipogenic stem cell differentiation, and revascularisation will also be analyzed.

免疫细胞对于再生的开始和成功完成再生过程是必不可少的。平衡的适应性免疫反应是再生级联反应的决定性因素，免疫调节策略代表了一种促进愈合的新治疗方法。尽管骨免疫学研究取得了显著进展，但获得性免疫往往未被考虑。在这里，我们将研究老年受损患者(肥胖/糖尿病)再生过程中获得性免疫的影响，开发一种分散不利免疫细胞参与愈合早期炎症反应的策略，并分析在骨愈合情况下骨痂形成过程中T细胞对骨痂形成过程中胶原1沉积和成骨前体细胞分布的影响。在与研究组其他项目的密切合作下，还将分析适应性免疫细胞对细胞衰老、成脂干细胞分化和血管重建的影响。