The three levels of structural nerve damage in the pathogenesis of diabetic polyneuropathy: defining therapeutic target markers using MR-Neurography (B05)

使用MR引导的显微切割，随后的蛋白质组学分析和体内MR神经造影，髓鞘形成障碍，反应代谢物的耗竭解毒和神经内脂肪沉积的增加可以被确定为驱动人类神经中糖尿病性多发性神经病的关键病理生理过程。作为一种具体的方法来研究这种变化的神经微结构在临床上，我们开发了一个扩散峰度MR神经造影。利用这些工具，我们的目标是：1）对新鲜组织标本进行更深入的分析; 2）在第三个资助期内，将其作为治疗干预（如外科神经减压术和减肥手术）的新治疗靶点标记物。

Using MR-guided microdissection with subsequent proteomic analyses and in vivo MR-Neurography, dysmyelination, exhausted detoxification of reative metabolites and an increase of intraneural fat deposits could be identified as critical pathophysiological processes driving diabetic polyneuropathy in human nervs. As a specific method to study such changes of the nervous microarchitecture in a clinical setting, we developed a diffusion-kurtosis MR-neurography. With these tools, we aim to 1) develop a more in-depth analysis of fresh tissue specimens and 2) establish them as new therapeutic target markers in the setting of therapeutic interventions such as surgical nerve decompression and bariatric surgery in the third funding period.