Cellular restriction of HIV-1 by 90K and SERINC5 and their sensitivity to evasion through viral cell-to-cell spread (C08)

90K 和 SERINC5 对 HIV-1 的细胞限制及其通过病毒细胞间传播逃避的敏感性 (C08)

• 批准号: 259939488
• 金额: --
• 依托单位: Liverpool School of Tropical Medicine
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/259939488?language=en
• 关键词: Cellular; restriction; HIV; 90K; SERINC5

The cellular proteins 90K and SERINC5 inhibit HIV-1 by reducing the infectivity of nascent particles through modulation of HIV-1 Env. The susceptibility of cell-associated virions, which spread through virological synapses, to restriction by these factors remains uninvestigated to date. This project proposal foresees the investigation of the role and impact of 90K and SERINC5 in the context of cell-to-cell transmission of HIV-1, and the elucidation of potential virus-mediated counteraction strategies directed against them.

细胞蛋白90K和SERINC5通过调节HIV-1 Env来降低新生颗粒的传染性，从而抑制HIV-1。通过病毒学突触传播的细胞相关病毒粒子对这些因素的限制的易感性至今仍未得到研究。该项目提案预计将研究90K和SERINC5在HIV-1细胞间传播中的作用和影响，并阐明针对它们的潜在病毒介导的对抗策略。