CCR8-driven immune functions of group 2 innate lymphoid cells (ILC2s) in atherosclerosis (A01)

CCR 8如何控制ILC 2在慢性血管炎症中的功能尚不清楚。因此，我们将（目的1）在体外表征CCR 8表达ILC 2，询问它们的转录组学特征、表型以及它们的代谢特征和响应于致动脉粥样硬化介质的潜在可塑性。此外，（目的2）我们将使用细胞特异性诱导型Cre/flox小鼠模型来关注ILC 2在体内的作用，以详细说明ILC 2和表达CCR 8的ILC 2在动脉粥样硬化中的相关性。在目标3中，我们阐明了CCL 17 + DC和ILC 2在动脉粥样硬化中的相互作用，并对我们的研究结果的临床翻译进行了随访，同时也涉及到治疗干预。

How CCR8 controls ILC2 function in chronic vascular inflammation is not understood. Thus, we will (Aim 1) characterize CCR8-expressing ILC2s in vitro interrogating their transcriptomic profile, phenotype as well as their metabolic profile and potential plasticity in response to atherogenic mediators. Further, (Aim 2) we will focus on the role of ILC2s in vivo using cell- specific inducible Cre/flox mouse models to detail on the relevance of ILC2s and CCR8-expressing ILC2s in atherosclerosis. In Aim 3 we elucidate the interplay of CCL17+ DCs and ILC2s in atherosclerosis and follow up on a clinical translation of our findings also with respect to therapeutic interventions.