CCR8-driven immune functions of group 2 innate lymphoid cells (ILC2s) in atherosclerosis (A01)

CCR8如何控制慢性血管炎症中的ILC2功能尚不清楚。因此，我们将（Aim 1）在体外表征表达ccr8的ILC2s，询问它们的转录组谱、表型以及代谢谱和对致动脉粥样硬化介质的潜在可塑性。此外，（目的2）我们将关注ILC2s在体内的作用，使用细胞特异性诱导的Cre/flox小鼠模型来详细研究ILC2s和表达ccr8的ILC2s在动脉粥样硬化中的相关性。在Aim 3中，我们阐明了CCL17+ dc和ILC2s在动脉粥样硬化中的相互作用，并在治疗干预方面跟进了我们研究结果的临床翻译。

How CCR8 controls ILC2 function in chronic vascular inflammation is not understood. Thus, we will (Aim 1) characterize CCR8-expressing ILC2s in vitro interrogating their transcriptomic profile, phenotype as well as their metabolic profile and potential plasticity in response to atherogenic mediators. Further, (Aim 2) we will focus on the role of ILC2s in vivo using cell- specific inducible Cre/flox mouse models to detail on the relevance of ILC2s and CCR8-expressing ILC2s in atherosclerosis. In Aim 3 we elucidate the interplay of CCL17+ DCs and ILC2s in atherosclerosis and follow up on a clinical translation of our findings also with respect to therapeutic interventions.