Template directed synthesis of complex monomer sequences in chain-growth polymerizations

自然界通过对生物聚合物中的单体序列施加极高程度的控制来获得高度复杂和功能的结构。该项目旨在开发一种方法，通过这种方法可以对链生长聚合合成的聚合物的单体序列施加更多的控制。具有复杂单体序列的聚合物的合成将通过超分子相互作用(氢键、金属-配体配位等)来完成。将单体与模板分子组装成定义明确的络合物。可聚合单元将紧密地位于这些络合物中，从而有利于掺入所需的单体序列。调节某些单体的反应性，从而引入交替共聚的趋势，将进一步增加复杂性。

Nature obtains highly complex and functional structures by exerting an extremely high degree of control over the monomer sequence in biopolymers. This projects aims to develop a method by which more control can be exerted over the monomer sequence of polymers synthesized by chain-growth polymerizations.The synthesis of polymers with complex monomer sequences will be accomplished by using supramolecular interactions (hydrogen-bonding, metal-ligand coordination, etc.) to assemble monomers into well-defined complexes with template molecules. The polymerizable units will be located close together in these complexes, thereby favoring the incorporation of the desired monomer sequence. Tuning the reactivity of certain monomers, whereby introducing a tendency toward alternating copolymerization, will increase the complexity further.