2023 Neurotrophic Mechanisms in Health and Disease

摘要 该提案旨在为早期职业研究人员、博士后研究员和学生提供支持， 参加戈登研究会议（GRC）在健康和疾病的神经营养机制和 戈登研究研讨会（GRS）。GRC将在Salve Regina大学纽波特RI举行 2023年5月28日至6月2日，以及5月27日至28日的GRS。神经营养因子，广义上定义为 在电路连接、突触可塑性和行为中起着关键作用，对发育至关重要， 神经系统的维护、修复和功能。重要的是，几种利用知识的治疗方法 神经营养蛋白生物学的最新研究成果现在已经用于慢性疼痛、阿尔茨海默病和癌症的人体临床试验。这 GRC是汇集基础研究人员和临床医生的不同社区的主要论坛 研究神经系统中的生长因子生物学。 2023年健康和疾病GRC中的神经营养机制是独一无二的，它汇集了多个 跨学科的研究人员在分子，细胞和生物学领域的基本问题， 将神经营养生物学转化为治疗方法。会议将提供一个 将神经营养因子生物学基础研究与临床需求和产业相结合的重要场所 兴趣，最终目标是加速开发和采用新的治疗人类疾病的方法。 神经发育和神经病症、精神疾病和某些形式的癌症。的 会议将汇集发言者，许多新的会议，谁将发言的交叉点， 神经营养蛋白生物学与回路形成，神经胶质/免疫信号传导，干细胞生物学，慢性疼痛， 抑郁症、组织修复和神经系统疾病。其他主题和最新进展将在 通过从摘要中选择的谈话纳入，特别是鼓励初级研究人员的参与。 有几个特点区分2023年GRC神经营养因子会议从早期的会议。这些 包括强调神经营养因子生物学与神经胶质细胞/免疫信号传导，干细胞， 组织修复和治疗途径，招募一批新参加会议的研究人员， 这些新兴领域，并提供新的观点，发言者谁是妇女的强大代表性 (57.1%），以及学术界历史上代表性不足的群体（20%），引入相关的两个- 为学生和博士后科学家提供为期一天的GRS，以促进初级科学家之间的联网，并介绍 对初级学员的教师指导制度。

Abstract This proposal is to provide support for early career investigators, post-doctoral fellows, and students to attend the Gordon Research Conference (GRC) on Neurotrophic Mechanisms in Health and Disease and the accompanying Gordon Research Seminar (GRS). The GRC will be held in Salve Regina University Newport RI from May 28-June 2 2023, and the GRS on May 27-28. Neurotrophic factors, broadly defined as factors that have critical roles in circuit connectivity, synaptic plasticity, and behavior, are essential for the development, maintenance, repair, and functions of the nervous system. Importantly, several treatments that exploit knowledge of neurotrophin biology are now in human clinical trials for chronic pain, Alzheimer's disease, and cancer. This GRC is the primary forum for bringing together diverse communities of basic researchers and clinicians investigating growth factor biology in the nervous system. The 2023 Neurotrophic Mechanisms in Health and Disease GRC is unique in bringing together a multi- disciplinary group of researchers in areas spanning fundamental problems in molecular, cellular, and developmental neuroscience to translating neurotrophin biology into therapies. The meeting will provide an important venue to integrate basic research on neurotrophic factor biology with clinical needs and industry interest, with the ultimate goal of accelerating the development and adoption of new treatments for human neurodevelopmental and neurological conditions, psychiatric diseases, and some forms of cancers. The conference will bring together speakers, many new to the meeting, who will speak to the intersection of neurotrophin biology with circuit formation, neuron-glia/immune signaling, stem cell biology, chronic pain, depression, tissue repair, and neurological disorders. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of junior researchers. Several features distinguish the 2023 GRC Neurotrophic Factor conference from earlier meetings. These include an emphasis on the intersection of neurotrophin biology with neuron-glia/immune signaling, stem cells, tissue repair, and therapeutic avenues, recruitment of a cohort of investigators new to the meeting who will speak to these emerging areas and provide fresh perspectives, robust representation of speakers who are women (57.1%), and from historically under-represented groups in academia (20%), introduction of an associated two- day GRS for students and postdoctoral scientists to facilitate networking among junior scientists, and introduction of a faculty mentoring system for junior trainees.