2023 Neurotrophic Mechanisms in Health and Disease

摘要 该建议旨在为早期职业研究人员、博士后研究员和学生提供支持，以 出席戈登研究会议(GRC)关于健康和疾病中的神经营养机制和 陪同戈登研究研讨会(GRS)。GRC将在Salve Regina University Newport RI举行 2023年5月28日至6月2日，5月27日至28日GRS。神经营养因子，广义上定义为 在电路连通性、突触可塑性和行为中起关键作用，对发育至关重要， 神经系统的维护、修复和功能。重要的是，几种利用知识的治疗方法 针对慢性疼痛、阿尔茨海默氏症和癌症的人体临床试验。这 GRC是汇聚基础研究人员和临床医生不同社区的主要论坛 研究神经系统中的生长因子生物学。 2023年健康和疾病中的神经营养机制GRC是独一无二的，它汇集了多个 研究人员组成的学科小组，研究领域涉及分子、细胞和 发展神经科学将神经营养素生物学转化为治疗。这次会议将提供一个 将神经营养因子生物学基础研究与临床需求和产业相结合的重要场所 兴趣，最终目标是加速人类新疗法的开发和采用 神经发育和神经疾病、精神疾病和某些形式的癌症。这个 会议将汇集演讲者，其中许多人是新来的，他们将在 神经营养因子生物学与回路形成，神经元-神经胶质/免疫信号，干细胞生物学，慢性疼痛， 抑郁、组织修复和神经紊乱。其他主题和最新进展将是 通过从摘要中挑选出来的演讲纳入，特别是鼓励初级研究人员的参与。 2023年GRC神经营养因子会议的几个特点有别于以前的会议。这些 包括强调神经营养因子生物学与神经元-神经胶质/免疫信号、干细胞、 组织修复和治疗途径，招募一批新参加会议的调查人员将发言 为这些新兴领域提供了新的视角，有力地代表了女性发言者 (57.1%)，从学术界历史上代表性不足的群体(20%)，引入了相关的两个- 为学生和博士后科学家提供日间GRS，以促进初级科学家之间的联系，并介绍 针对初级实习生的教师指导系统。

Abstract This proposal is to provide support for early career investigators, post-doctoral fellows, and students to attend the Gordon Research Conference (GRC) on Neurotrophic Mechanisms in Health and Disease and the accompanying Gordon Research Seminar (GRS). The GRC will be held in Salve Regina University Newport RI from May 28-June 2 2023, and the GRS on May 27-28. Neurotrophic factors, broadly defined as factors that have critical roles in circuit connectivity, synaptic plasticity, and behavior, are essential for the development, maintenance, repair, and functions of the nervous system. Importantly, several treatments that exploit knowledge of neurotrophin biology are now in human clinical trials for chronic pain, Alzheimer's disease, and cancer. This GRC is the primary forum for bringing together diverse communities of basic researchers and clinicians investigating growth factor biology in the nervous system. The 2023 Neurotrophic Mechanisms in Health and Disease GRC is unique in bringing together a multi- disciplinary group of researchers in areas spanning fundamental problems in molecular, cellular, and developmental neuroscience to translating neurotrophin biology into therapies. The meeting will provide an important venue to integrate basic research on neurotrophic factor biology with clinical needs and industry interest, with the ultimate goal of accelerating the development and adoption of new treatments for human neurodevelopmental and neurological conditions, psychiatric diseases, and some forms of cancers. The conference will bring together speakers, many new to the meeting, who will speak to the intersection of neurotrophin biology with circuit formation, neuron-glia/immune signaling, stem cell biology, chronic pain, depression, tissue repair, and neurological disorders. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of junior researchers. Several features distinguish the 2023 GRC Neurotrophic Factor conference from earlier meetings. These include an emphasis on the intersection of neurotrophin biology with neuron-glia/immune signaling, stem cells, tissue repair, and therapeutic avenues, recruitment of a cohort of investigators new to the meeting who will speak to these emerging areas and provide fresh perspectives, robust representation of speakers who are women (57.1%), and from historically under-represented groups in academia (20%), introduction of an associated two- day GRS for students and postdoctoral scientists to facilitate networking among junior scientists, and introduction of a faculty mentoring system for junior trainees.