Development and evaluation of dynamic nuclear polarization for vascular and perfusion imaging at 1.5 tesla

1.5 特斯拉血管和灌注成像动态核极化的开发和评估

• 批准号: 263401258
• 负责人: Dr. Sebastian Fischer
• 金额: --
• 依托单位: Institut für Physikalische und Theoretische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/263401258?language=en
• 关键词: Development; evaluation; dynamic; nuclear; polarization

Aim of the study is to evaluate the feasibility of dynamic nuclear polarization in a magnetic field of 1.5 tesla for in-vivo contrast imaging. The technique of generating hyperpolarized water molecules to be used as a contrast agent could possibly be an inert alternative to gadolinium based contrast agents currently used.It is planned to test this novel technique for vascular and perfusion imaging in two murine models: transgene mice developing hepatocellular carcinomas shall evaluate the power of the dnp technique in comparison to conventional gadolinium based contrast imaging in carcinoma diagnostics. The possible usage in ischemia diagnostics is planned to be evaluated in a murine stroke model.

本研究的目的是评估在1.5特斯拉的磁场中动态核极化用于体内对比成像的可行性。产生超极化水分子的技术被用作造影剂可能是一种惰性的替代钆为基础的造影剂目前used.It计划测试这种新技术的血管和灌注成像在两个小鼠模型：转基因小鼠发展肝细胞癌应评估的权力dnp技术相比，传统的钆为基础的造影成像在癌症诊断。计划在鼠中风模型中评价在缺血诊断中的可能用途。