Assessment of cerebral metabolic and microstructural alterations in aging human brain and in patients by using an innovative whole brain 1H magnetic resonance spectroscopic technique in combination with quantitative magnetic resonance imaging
通过使用创新的全脑 1H 磁共振波谱技术结合定量磁共振成像来评估衰老人脑和患者的脑代谢和微结构变化
基本信息
- 批准号:263370457
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2014
- 资助国家:德国
- 起止时间:2013-12-31 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In the first funding period (from 01.04.2015 to 31.03.2017), we have studied normal aging effects on main brain metabolite NAA, Cho, tCr and brain tissue T2 relaxation times at 13 selected specific regions of brain interests (Eylers et al. 2016). We have also studied physiological neuronal decline in healthy aging human brain with short echo-time whole brain MR spectroscopic imaging (wbMRSI) by determining age-related changes in fractional volumes of brain tissue and in metabolite concentrations of not only NAA, Cho, tCr, but also Glx and mI over large brain lobar structures (Ding et al. 2016). Both studies revealed interested results that allowed new insight into the physiological process in healthy aging brain and the data have been published. However, there are certain weakness: Limited by used long echo time (TE 70 ms) in the first subproject specific local metabolite distributions were measured only for the main metabolites NAA, Cho, and tCr, whereas the metabolites Glx and mI that are often sensitive to different pathological conditions could not be considered; The results of the second subproject were obtained at large scale of brain structures (eight cerebral lobes and cerebellum), thus not applicable for small and specific brain structures that are often interested in patient study. With present proposal we are, at first, going to combine short echo time wbMRSI with qMR imaging including determinations of T2 and T1 relaxation times of brain tissue, as well as with volumetric MRI to study healthy volunteers, with the purpose to intensify our investigation of physiological neuronal decline in healthy aging human brain. All parameter measurements will be made at multiple brain small specific structures, with the aim to study inhomogeneous metabolic and microstructural aging effects in human brain, and the collected data could be used as reference data for studying brain disorders with diffuse or multifocal metabolic and microstructural alterations. In a second project, as a first application of the established wbMRSI method to study a patient group systematically, we plan to study neurometabolic and microstructural alterations resulted from chronic neurotoxicity of calcineurin inhibitors in patients after liver transplantation. The founded metabolic and microstructural alterations in patients will be related to the results of neuro-psychometric tests and compared to those of healthy controls to find possible origin of CNS functional deficits, which may give reason for improvement of the clinical therapy in the future.
在第一个资助期(2015年4月01日至2017年3月31日),我们研究了正常老化对大脑主要代谢物NAA、CHO、TCR和脑组织T2松弛时间的影响,这些影响涉及13个特定的大脑兴趣区域(Eylers等人)。2016)。我们还用短回声时间全脑磁共振光谱成像(WbMRSI)研究了健康老龄化人脑的生理性神经元衰退,方法是测定脑组织分数体积和大脑叶结构上NAA、Cho、TCR以及Glx和mi的代谢物浓度随年龄的变化(Ding等人)。2016)。这两项研究都显示了令人感兴趣的结果,使人们能够对健康衰老大脑的生理过程有新的见解,数据已经发表。但也有一定的不足:第一个子项目由于使用了较长的回声时间(TE 70ms),只测量了主要代谢物NAA、CHO和TCR的局部代谢物分布,而没有考虑经常对不同病理条件敏感的代谢物GLX和MI;第二个子项目的结果是在大规模的脑结构(八个大脑叶和小脑)上获得的,因此不适用于患者经常感兴趣的小而特定的脑结构。本研究首先将短回声时间磁共振波谱成像与QMR成像相结合,包括测定脑组织的T2和T1弛豫时间,并结合体积磁共振成像对健康志愿者进行研究,目的是加强对健康老化人脑生理性神经元衰退的研究。所有参数测量将在多个大脑小的特定结构上进行,目的是研究人脑的不均匀代谢和微结构衰老效应,所收集的数据可作为研究弥漫性或多灶性代谢和微结构改变的脑疾病的参考数据。在第二个项目中,作为第一次应用已建立的wbMRSI方法系统地研究患者组,我们计划研究由于钙调神经磷酸酶抑制剂的慢性神经毒性导致的肝移植后患者的神经代谢和微结构变化。已发现的代谢和微结构改变将与神经心理测试结果相关联,并与健康对照组进行比较,以寻找中枢神经系统功能缺陷的可能原因,这可能为今后改进临床治疗提供依据。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Altered Neurometabolic Profile in Early Parkinson's Disease: A Study With Short Echo-Time Whole Brain MR Spectroscopic Imaging
- DOI:10.3389/fneur.2019.00777
- 发表时间:2019-07-17
- 期刊:
- 影响因子:3.4
- 作者:Klietz, Martin;Bronzlik, Paul;Ding, Xiao-Qi
- 通讯作者:Ding, Xiao-Qi
Quantitative magnetic resonance imaging indicates brain tissue alterations in patients after liver transplantation
定量磁共振成像显示肝移植后患者脑组织的变化
- DOI:10.1371/journal.pone.0222934
- 发表时间:2019
- 期刊:
- 影响因子:3.7
- 作者:Pflugrad;Schmitz;Lanfermann;Barg-Hock;Klempnauer;Weissenborn
- 通讯作者:Weissenborn
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