SFB 1190: Compartmental Gates and Contact Sites in Cells

细胞的区隔化确保了核酸、蛋白质和代谢物的高度特异性分布。与此同时，细胞内的隔室必须相互沟通和交换分子。两个主要的系统可以实现隔室之间的交换：隔室门和接触点。虽然隔室门介导细胞质和细胞器之间或膜内分子的选择性分配，但接触位点代表隔室包围膜之间的直接物理连接。因此，在活细胞内，区隔门和接触点代表了两个互补的系统，它们在功能上相互合作或直接相互作用，以协调区隔化过程。SFB1190致力于解决区隔门和接触位点在细胞组织和生理中的作用。我们的目标是了解它们如何实现分子的选择性分布，从而在功能上定义和多样化细胞区室。

The compartmentalization of cells ensures a highly specific distribution of nucleic acids, proteins and metabolites. At the same time, intracellular compartments must communicate and exchange molecules. Two major systems enable exchange between compartments: compartmental gates and contact sites. While compartmental gates mediate the selective partitioning of molecules between cytoplasm and organelles or within a membrane, contact sites represent direct physical connections between compartment-enclosing membranes. Thus, within living cells, compartmental gates and contact sites represent two complementary systems, which functionally cooperate or directly interact with each other to coordinate compartmentalized processes. The SFB1190 is committed to addressing the role of compartmental gates and contact sites in cellular organization and physiology. We aim to understand how they achieve a selective distribution of molecules and thus functionally define and diversify cellular compartments.