SFB 1190: Compartmental Gates and Contact Sites in Cells

细胞的区隔确保了核酸、蛋白质和代谢物的高度特异性分布。与此同时，细胞内的隔间必须进行分子的沟通和交换。两个主要系统实现了车厢之间的交换：车厢门和接触点。虽然隔室门在细胞质和细胞器之间或在膜内调节分子的选择性分配，但接触点代表隔室包围膜之间的直接物理连接。因此，在活细胞内，隔间门和接触部位代表着两个互补的系统，它们在功能上相互协作或直接相互作用，以协调分隔的过程。SFB1190致力于解决间隔门和接触点在细胞组织和生理中的作用。我们的目标是了解它们如何实现分子的选择性分布，从而在功能上定义和多样化细胞隔间。

The compartmentalization of cells ensures a highly specific distribution of nucleic acids, proteins and metabolites. At the same time, intracellular compartments must communicate and exchange molecules. Two major systems enable exchange between compartments: compartmental gates and contact sites. While compartmental gates mediate the selective partitioning of molecules between cytoplasm and organelles or within a membrane, contact sites represent direct physical connections between compartment-enclosing membranes. Thus, within living cells, compartmental gates and contact sites represent two complementary systems, which functionally cooperate or directly interact with each other to coordinate compartmentalized processes. The SFB1190 is committed to addressing the role of compartmental gates and contact sites in cellular organization and physiology. We aim to understand how they achieve a selective distribution of molecules and thus functionally define and diversify cellular compartments.