Die circannuale Uhr, ihre Lokalisation und Synchronisation

昼夜时钟、其定位和同步

基本信息

项目摘要

The aim of this project is to 1) localize the circannual clock, to investigate 2) the possibility that the circannual clock might get photoperiodic information by other pathways than melatonin and 3) the particularities of photoperiodic time measurement in the field. My model species is the circannual European hamster whose circannual driven changes in the daily activity pattern characterize an annual phase of sensitivity to short photoperiods. Thus, at the beginning and the end of the sensitive phase the circadian and the circannual clock communicate and the brain areas that form the circannual clock should show a different metabolism than at other times of year. To visualize this the functional magnetic resonance imaging technique will be adapted to European hamsters with the aim to localize the circannual clock. Recent studies suggested that in European hamsters not only melatonin mediates photoperiodic information to the circannual clock. To test this, pinealectomized animals will be subjected to an exotic photoperiodic cycle. A synchronization would prove the existence of such a pathway, which then will be explored. A third study will address the question of the decline of European hamsters in Western Europe where females have too few litters per year to ensure the continuity of the population. This might be due to a major delay in emergence from hibernacula and thus due to a misaligned circannual clock. In outdoor enclosures, recording techniques will be developed to examine photoperiodic time measurement in the field.
本项目的目的是:1)定位昼夜时钟,调查2)昼夜时钟可能通过其他途径而不是褪黑激素获得光周期信息的可能性和3)光周期时间测量的特殊性。我的模式物种是欧洲仓鼠的circannual驱动的变化,在日常活动模式的特点是一个年度阶段的敏感性短光周期。因此,在敏感阶段的开始和结束时,昼夜节律和昼夜时钟进行通信,形成昼夜时钟的大脑区域应该显示出与一年中其他时间不同的新陈代谢。为了可视化,功能性磁共振成像技术将适用于欧洲仓鼠,目的是定位昼夜时钟。最近的研究表明,在欧洲仓鼠不仅褪黑激素介导光周期信息的昼夜时钟。为了测试这一点,松果体切除动物将受到外来光周期循环。同步将证明这样一条途径的存在,然后将对其进行探索。第三项研究将解决西欧欧洲仓鼠数量下降的问题,因为西欧雌性仓鼠每年的产仔数太少,无法确保种群的连续性。这可能是由于从冬眠中出现的主要延迟,因此是由于一个失调的昼夜时钟。在室外围栏,记录技术将被开发,以检查光周期时间测量在现场。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Dr. Stefanie Monecke其他文献

Dr. Stefanie Monecke的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了