Oxytocin in the prefrontal cortex: from neuromodulation of the local circuit to fear extinction (C05)

前额皮质中的催产素：从局部回路的神经调节到恐惧消退（C05）

• 批准号: 267474020
• 金额: --
• 依托单位: Deutsches Krebsforschungszentrum (DKFZ)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/267474020?language=en
• 关键词: Oxytocin; prefrontal; cortex; neuromodulation; local

Our project is focused on the role of neuropeptide oxytocin (OT) in the ventral hippocampus (vHippo)-based control of social behaviour. We propose that OT in the vHippo CA1 region is crucial for formation of local functional neuronal assembles involved in processing of social memories. Our preliminary data provide evidence for the existence of heterogeneous OT-receptive microcircuit, composed of interneurons expressing calcium binding protein parvalbumin and sub-type of CA1 pyramidal cells in vHippo. This local network segregates the OT-receptive output pyramidal cells into specific pathway transferring OT-driven information to long-distance targets (such as the accessory olfactory bulb). We will demonstrate how this newly described local and distant functionally connected neuronal ensembles contribute to the formation of social memory and social behaviour.

我们的项目集中在神经肽催产素（OT）在腹侧海马（vHippo）的社会行为控制中的作用。 我们建议，OT在vHippo CA 1区是至关重要的，形成当地的功能性神经元组装参与处理的社会记忆。我们的初步数据提供了证据的异质OT-接受微电路的存在，由中间神经元表达钙结合蛋白parvalbumin和亚型的CA 1锥体细胞在vHippo。该局部网络将OT-感受性输出锥体细胞分离成将OT-驱动的信息传递到远距离目标（例如副嗅球）的特定通路。我们将展示这种新描述的本地和远程功能连接的神经元集合如何有助于社会记忆和社会行为的形成。