Oxytocin in the prefrontal cortex: from neuromodulation of the local circuit to fear extinction (C05)

我们的项目集中在神经肽催产素(OT)在腹侧海马区(VHippo)对社会行为的控制中的作用。我们认为，vHippo CA1区的OT对于参与社会记忆加工的局部功能神经元组装的形成至关重要。我们的初步数据为vHippo内存在异质性OT受体微回路提供了证据，该微回路由表达钙结合蛋白PPAR的中间神经元和CA1锥体细胞亚型组成。这个局部网络将催产素感受性输出锥体细胞分离成特定的通路，将催产素驱动的信息传递到远距离目标(如副嗅球)。我们将展示这种新描述的局部和远程功能连接的神经元群如何有助于社会记忆和社会行为的形成。

Our project is focused on the role of neuropeptide oxytocin (OT) in the ventral hippocampus (vHippo)-based control of social behaviour. We propose that OT in the vHippo CA1 region is crucial for formation of local functional neuronal assembles involved in processing of social memories. Our preliminary data provide evidence for the existence of heterogeneous OT-receptive microcircuit, composed of interneurons expressing calcium binding protein parvalbumin and sub-type of CA1 pyramidal cells in vHippo. This local network segregates the OT-receptive output pyramidal cells into specific pathway transferring OT-driven information to long-distance targets (such as the accessory olfactory bulb). We will demonstrate how this newly described local and distant functionally connected neuronal ensembles contribute to the formation of social memory and social behaviour.