Oxytocin in the prefrontal cortex: from neuromodulation of the local circuit to fear extinction (C05)

我们的项目重点是神经肽催产素（OT）在腹侧海马体（vHippo）为基础的社会行为控制中的作用。我们认为，在vHippo CA1区域的OT对于参与社会记忆处理的局部功能性神经元组装的形成至关重要。我们的初步数据表明，vHippo存在由表达钙结合蛋白小白蛋白的中间神经元和CA1锥体细胞亚型组成的异质受体微回路。这个局部网络将接受ot的输出锥体细胞分离成特定的通路，将ot驱动的信息传递给远距离的目标（如副嗅球）。我们将展示这种新描述的局部和远距离功能连接的神经元群如何促进社会记忆和社会行为的形成。

Our project is focused on the role of neuropeptide oxytocin (OT) in the ventral hippocampus (vHippo)-based control of social behaviour. We propose that OT in the vHippo CA1 region is crucial for formation of local functional neuronal assembles involved in processing of social memories. Our preliminary data provide evidence for the existence of heterogeneous OT-receptive microcircuit, composed of interneurons expressing calcium binding protein parvalbumin and sub-type of CA1 pyramidal cells in vHippo. This local network segregates the OT-receptive output pyramidal cells into specific pathway transferring OT-driven information to long-distance targets (such as the accessory olfactory bulb). We will demonstrate how this newly described local and distant functionally connected neuronal ensembles contribute to the formation of social memory and social behaviour.