Contributions of hippocampal oxytocin receptors to social recognition
海马催产素受体对社会认可的贡献
基本信息
- 批准号:10300447
- 负责人:
- 金额:$ 42.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-11-15 至 2024-10-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAnxietyAttenuatedBehaviorBehavioralBiological ProcessCellsCellular Compartment AnalysisCodeCommunicationComplexDataDiseaseDorsalExcisionExposure toFeedbackFemaleFluorescent in Situ HybridizationGeneticGleanGoalsHilarHippocampus (Brain)ImageImpairmentLateralLightLinkMammalsMediatingMemoryMental disordersMusNeural PathwaysNeuromodulatorNeuronsNoiseNucleus AccumbensOxytocinOxytocin ReceptorPathway interactionsPatternPharmacologyPrefrontal CortexProcessProsencephalonReceptor SignalingRewardsRoleSignal TransductionSocial BehaviorSocial DiscriminationSocial InteractionStimulusTestingViralattenuationautism spectrum disorderavoidance behaviorbasecognitive processconditional mutantdentate gyrusdesignhippocampal pyramidal neuroninsightmalememory processneural circuitneuromechanismnovelnovel therapeutic interventionobject recognitionoptogeneticspopulation basedreceptor expressionsocialsocial separationtool
项目摘要
Project Summary
Social recognition in mammals is a complex biological process that necessitates communication between
neural circuits mediating cognitive processes such as discrimination of social stimuli and those underlying
expression of affiliation or avoidance behaviors. Circuit alterations that impair social discrimination, social
interaction or linkage of social discrimination with social interaction may underlie social recognition deficits
seen in autism spectrum disorders and other psychiatric disorders. One general mechanism by which distinct
behaviors such as reward seeking, social exploration and discrimination of social stimuli are orchestrated is
through the actions of neuromodulators such as oxytocin (OT). Although a growing number of studies have
begun to shed light on oxytocin receptor (Oxtr) signaling in the nucleus accumbens, lateral septum and
prefrontal cortex in social interaction, the contribution of Oxtrs in the hippocampus to social memory is not
known. This proposal seeks to identify (i) fundamental circuit mechanisms by which hippocampal Oxtr
signaling promotes discrimination of social stimuli and, (ii) the neural pathways that link these computations
with circuits that subserve social interaction. Towards these goals, we will harness viral and mouse conditional
genetic tools, optogenetics, cellular ensemble imaging and behavior to precisely manipulate hippocampal Oxtr
signaling with unprecedented spatial and temporal control and determine its contributions to social
recognition. Insights gleaned from the proposed studies will shed light on how an ancient neuromodulator like
OT has evolved to utilize basic memory-processing circuit mechanisms to perform discrimination of social
stimuli. The significance of the studies lies in its potential to illuminate fundamental neural mechanisms
underlying previously unrecognized roles of hippocampal Oxtr signaling in social recognition. Ultimately,
these mechanisms may guide novel therapeutic strategies for promoting social recognition in disorders in
which it is impaired.
项目摘要
哺乳动物的社会识别是一个复杂的生物学过程,需要它们之间的交流。
神经回路介导的认知过程,如社会刺激的歧视和那些潜在的
表示归属或回避行为。电路改变损害社会歧视,社会
社会歧视与社会交往的相互作用或联系可能是社会承认缺陷的基础
在自闭症谱系障碍和其他精神疾病中可见。一种通用机制,
行为,如奖励寻求,社会探索和社会刺激的歧视是精心策划的,
通过神经调节剂如催产素(OT)的作用。尽管越来越多的研究表明,
开始揭示催产素受体(Oxtr)信号在脑桥核,外侧隔,
虽然前额叶皮层在社会交往中起作用,但海马体中Oxtrs对社会记忆的贡献并不明显。
知道的这项建议旨在确定(i)海马Oxtr
信号促进社会刺激的歧视,(ii)连接这些计算的神经通路
有着促进社会互动的电路为了实现这些目标,我们将利用病毒和小鼠条件
遗传工具,光遗传学,细胞整体成像和行为,以精确操纵海马Oxtr
信号与前所未有的空间和时间控制,并确定其对社会的贡献
识别.从拟议的研究中收集到的见解将阐明一种古老的神经调节剂,如
OT已经发展到利用基本的记忆处理电路机制来执行社会识别。
刺激。这些研究的意义在于它有可能阐明基本的神经机制
海马Oxtr信号在社会识别中的潜在作用。最后,
这些机制可以指导新的治疗策略,以促进社会承认的障碍,
它是受损的。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hippocampal oxytocin receptors are necessary for discrimination of social stimuli.
- DOI:10.1038/s41467-017-02173-0
- 发表时间:2017-12-08
- 期刊:
- 影响因子:16.6
- 作者:Raam T;McAvoy KM;Besnard A;Veenema AH;Sahay A
- 通讯作者:Sahay A
Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence.
- DOI:10.1038/s41586-021-03417-2
- 发表时间:2021-04
- 期刊:
- 影响因子:64.8
- 作者:Choi S;Zhang B;Ma S;Gonzalez-Celeiro M;Stein D;Jin X;Kim ST;Kang YL;Besnard A;Rezza A;Grisanti L;Buenrostro JD;Rendl M;Nahrendorf M;Sahay A;Hsu YC
- 通讯作者:Hsu YC
A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation.
- DOI:10.7554/elife.70586
- 发表时间:2022-02-22
- 期刊:
- 影响因子:7.7
- 作者:Twarkowski H;Steininger V;Kim MJ;Sahay A
- 通讯作者:Sahay A
Enhancing adult neurogenesis promotes contextual fear memory discrimination and activation of hippocampal-dorsolateral septal circuits.
增强成人神经发生促进情境恐惧记忆辨别和海马背外侧间隔回路的激活。
- DOI:10.1016/j.bbr.2020.112917
- 发表时间:2021-02-05
- 期刊:
- 影响因子:2.7
- 作者:Besnard A;Sahay A
- 通讯作者:Sahay A
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Amar Sahay其他文献
Amar Sahay的其他文献
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{{ truncateString('Amar Sahay', 18)}}的其他基金
Hippocampal synaptic and circuit mechanisms mediating Dyrk1a functions in social cognition
海马突触和回路机制介导 Dyrk1a 在社会认知中的功能
- 批准号:
10562383 - 财政年份:2023
- 资助金额:
$ 42.25万 - 项目类别:
Targeting neurogenesis-inhibition coupling to improve memory in aging
靶向神经发生-抑制耦合以改善衰老记忆
- 批准号:
10426470 - 财政年份:2022
- 资助金额:
$ 42.25万 - 项目类别:
Targeting neurogenesis-inhibition coupling to improve memory in aging
靶向神经发生-抑制耦合以改善衰老记忆
- 批准号:
10851086 - 财政年份:2022
- 资助金额:
$ 42.25万 - 项目类别:
Targeting neurogenesis-inhibition coupling to improve memory in aging\Diversity Supplement
靶向神经发生-抑制耦合以改善衰老多样性补充剂的记忆力
- 批准号:
10670533 - 财政年份:2022
- 资助金额:
$ 42.25万 - 项目类别:
Targeting neurogenesis-inhibition coupling to improve memory in aging
靶向神经发生-抑制耦合以改善衰老记忆
- 批准号:
10629324 - 财政年份:2022
- 资助金额:
$ 42.25万 - 项目类别:
Transcriptional Control of adult hippocampal neural stem cell homeostasis
成人海马神经干细胞稳态的转录控制
- 批准号:
10201930 - 财政年份:2020
- 资助金额:
$ 42.25万 - 项目类别:
Contributions of hippocampal oxytocin receptors to social recognition
海马催产素受体对社会认可的贡献
- 批准号:
10286210 - 财政年份:2017
- 资助金额:
$ 42.25万 - 项目类别:
Contributions of hippocampal oxytocin receptors to social recognition
海马催产素受体对社会认可的贡献
- 批准号:
10056173 - 财政年份:2017
- 资助金额:
$ 42.25万 - 项目类别:
Re-engineering excitation-inhibition connectivity to rejuvenate memory circuits in aging
重新设计兴奋-抑制连接以恢复衰老过程中的记忆电路
- 批准号:
9028637 - 财政年份:2016
- 资助金额:
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Molecular control of excitation-inhibition balance to encode ambiguous threats
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9237311 - 财政年份:2014
- 资助金额:
$ 42.25万 - 项目类别:
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