Intracellular Communication of Gliomas via Exosomes

神经胶质瘤通过外泌体进行细胞内通讯

• 批准号: 267490279
• 负责人: Privatdozent Dr. Franz Ricklefs
• 金额: --
• 依托单位: Klinik und Poliklinik für Neurochirurgie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/267490279?language=en
• 关键词: Intracellular; Communication; Gliomas; via; Exosomes

Malignant gliomas evade therapy because of their complex and adaptive cellular composition, their ability to evade most therapies through compensatory mechanisms and the difficulty to deliver drugs.Complementing the mechanistic understanding of intratumoural cellular communication and signaling, extracellular vesicles (EVs) have been identified as transporters of signaling molecules between cells and micro-RNAs have been identified as a key content of these EVs. Recent data from several investigators have shown that the introduction of selected miRs into tumor cells can affect their growth, proliferation, stemness and radio-resistance.The outlined project aims to contribute to the in depth analysis EV mediated modulation of cellular phenotypes and functional adaptation via micro-RNA signaling. The goal is to develop strategies based on EV technology and miR pharmacology for novel therapies against glioblastoma.

恶性胶质瘤由于其复杂和适应性的细胞组成、通过代偿机制逃避大多数治疗的能力以及药物输送的困难而逃避治疗。细胞外小泡(EVS)被认为是细胞和微RNA之间信号分子的转运体，这补充了对肿瘤内细胞通信和信号转导的机制理解。最近来自几个研究人员的数据表明，将选定的miRs导入肿瘤细胞可以影响其生长、增殖、干性和放射抗性。该项目旨在深入分析EV介导的细胞表型调控和通过Micro-RNA信号传递的功能适应。目标是开发基于EV技术和miR药理学的策略，用于治疗胶质母细胞瘤的新疗法。

项目成果

Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma

• DOI: 10.1093/neuonc/nox139
• 发表时间: 2018-02-01
• 期刊: NEURO-ONCOLOGY
• 影响因子: 15.9
• 作者: Speranza, Maria-Carmela;Passaro, Carmela;Lawler, Sean E.
• 通讯作者: Lawler, Sean E.